Implications and Management of Cirrhosis-Associated Immune Dysfunction Before and After Liver Transplantation.
Thomas H. Tranah,Thomas H. Tranah,Victoria T. Kronsten,Victoria T. Kronsten,Debbie L. Shawcross,Debbie L. Shawcross +5 more
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TLDR
In this article, the authors summarize the detailed dynamic immunological perturbations associated with advanced chronic liver disease and highlight the importance of recognizing immune dysregulation as a sequela of cirrhosis.About:
This article is published in Liver Transplantation.The article was published on 2021-11-05 and is currently open access. It has received 3 citations till now. The article focuses on the topics: Chronic liver disease & Liver transplantation.read more
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Assessment of neutrophil subsets and immune checkpoint inhibitor expressions on T lymphocytes in liver transplantation: A preliminary study beyond the neutrophil-lymphocyte ratio
M. Haem Rahimi,M.C. Delignette,Morgane Gossez,Rémy Coudereau,Solene Pantel,Teresa Antonini,Francois Villeret,Fabien Zoulim,Jean-Yves Mabrut,Jérôme Dumortier,Fabienne Venet,Fanny Lebossé,Guillaume Monneret +12 more
TL;DR: In this article , the absolute count of immature neutrophils and LOX-1+ MDSC along with T lymphocyte count and checkpoint inhibitor expression were altered in cirrhotic patients before and after liver transplant.
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Characteristics of infections and their risk factors in children with biliary atresia.
Henry Shiau,Jeremy M. Schraw,Krupa R. Mysore,Laurel Cavallo,Sanjiv Harpavat,Philip J. Lupo,Flor M. Munoz,Benjamin L. Shneider +7 more
TL;DR: In this article , a retrospective observational study identified infections in children with biliary atresia (BA) using predefined criteria, including VRI, bacteremia with and without central line (CL), bacterial peritonitis, positive stool pathogens, urinary tract infections, and cholangitis.
Journal ArticleDOI
Beyond Varices: Complications of Cirrhotic Portal Hypertension in Pediatrics
TL;DR: In this paper , the authors summarize the current literature in adults who experience these complications of cirrhotic portal hypertension beyond variceal hemorrhage and present the available literature in children, with a focus on diagnosis, management, and liver transplant decision making in children with cirrhosis who develop ascites, SBP, HRS, HE, and cardiopulmonary complications.
References
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Short-Chain Fatty Acids Manifest Stimulative and Protective Effects on Intestinal Barrier Function Through the Inhibition of NLRP3 Inflammasome and Autophagy
TL;DR: It is suggested that SCFAs stimulate the formation of intestinal barrier, and protect the intestinal barrier from the disruption of LPS through inhibiting NLRP3 inflammasome and autophagy.
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Management of the critically ill patient with cirrhosis: A multidisciplinary perspective
Mitra K. Nadim,François Durand,John A. Kellum,Josh Levitsky,Jacqueline G. O'Leary,Constantine J. Karvellas,Jasmohan S. Bajaj,Andrew Davenport,Rajiv Jalan,Paolo Angeli,Stephen H. Caldwell,Javier Fernández,Claire Francoz,Guadalupe Garcia-Tsao,Pere Ginès,Michael G. Ison,David J. Kramer,Ravindra L. Mehta,Richard Moreau,David C. Mulligan,Jody C. Olson,Elizabeth A. Pomfret,Marco Senzolo,Randolph H. Steadman,Ram M. Subramanian,Jean Louis Vincent,Yuri Genyk +26 more
TL;DR: The management of the critically ill patient with cirrhosis: A multidisciplinary perspective is presented from a multi-disciplinary perspective.
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Immunosuppression in acutely decompensated cirrhosis is mediated by prostaglandin E2.
Alastair O'Brien,James N. Fullerton,Karen A. Massey,Grace Auld,Gavin W. Sewell,Sarah James,Justine Newson,Effie Karra,Alison Winstanley,William Alazawi,Rita García-Martínez,Joan Cordoba,Anna Nicolaou,Derek W. Gilroy +13 more
TL;DR: Treatment with COX inhibitors or albumin restored immune competence and survival following infection with group B Streptococcus and taken together, human albumin solution infusions may be used to reduce circulating PGE2 levels, attenuating immune suppression and reducing the risk of infection in patients with acutely decompensated cirrhosis or ESLD.
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Liver sinusoidal endothelial cells — gatekeepers of hepatic immunity
TL;DR: The role of LSECs in initiating immune responses and contributing to progressive liver disease makes them a potential therapeutic target for treating inflammatory liver diseases.
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COVID-19 and liver disease: mechanistic and clinical perspectives.
Thomas Marjot,Gwilym J. Webb,Alfred S. Barritt,Andrew M. Moon,Zania Stamataki,Vincent Wai-Sun Wong,Eleanor Barnes +6 more
TL;DR: In this article, the authors discuss the hepatotropism of SARS-CoV-2, including the differential expression of viral receptors on liver cell types, and describe the liver histology features present in patients with COVID-19.