Implications and Management of Cirrhosis-Associated Immune Dysfunction Before and After Liver Transplantation.
Thomas H. Tranah,Thomas H. Tranah,Victoria T. Kronsten,Victoria T. Kronsten,Debbie L. Shawcross,Debbie L. Shawcross +5 more
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TLDR
In this article, the authors summarize the detailed dynamic immunological perturbations associated with advanced chronic liver disease and highlight the importance of recognizing immune dysregulation as a sequela of cirrhosis.About:
This article is published in Liver Transplantation.The article was published on 2021-11-05 and is currently open access. It has received 3 citations till now. The article focuses on the topics: Chronic liver disease & Liver transplantation.read more
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Assessment of neutrophil subsets and immune checkpoint inhibitor expressions on T lymphocytes in liver transplantation: A preliminary study beyond the neutrophil-lymphocyte ratio
M. Haem Rahimi,M.C. Delignette,Morgane Gossez,Rémy Coudereau,Solene Pantel,Teresa Antonini,Francois Villeret,Fabien Zoulim,Jean-Yves Mabrut,Jérôme Dumortier,Fabienne Venet,Fanny Lebossé,Guillaume Monneret +12 more
TL;DR: In this article , the absolute count of immature neutrophils and LOX-1+ MDSC along with T lymphocyte count and checkpoint inhibitor expression were altered in cirrhotic patients before and after liver transplant.
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Characteristics of infections and their risk factors in children with biliary atresia.
Henry Shiau,Jeremy M. Schraw,Krupa R. Mysore,Laurel Cavallo,Sanjiv Harpavat,Philip J. Lupo,Flor M. Munoz,Benjamin L. Shneider +7 more
TL;DR: In this article , a retrospective observational study identified infections in children with biliary atresia (BA) using predefined criteria, including VRI, bacteremia with and without central line (CL), bacterial peritonitis, positive stool pathogens, urinary tract infections, and cholangitis.
Journal ArticleDOI
Beyond Varices: Complications of Cirrhotic Portal Hypertension in Pediatrics
TL;DR: In this paper , the authors summarize the current literature in adults who experience these complications of cirrhotic portal hypertension beyond variceal hemorrhage and present the available literature in children, with a focus on diagnosis, management, and liver transplant decision making in children with cirrhosis who develop ascites, SBP, HRS, HE, and cardiopulmonary complications.
References
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The outcomes of adult liver transplants in the United States from 1987 to 2013.
Maria Stepanova,Maria Stepanova,Homan Wai,Sammy Saab,Alita Mishra,Alita Mishra,Chapy Venkatesan,Chapy Venkatesan,Zobair M. Younossi,Zobair M. Younossi +9 more
TL;DR: Assessment of changes in outcomes of liver transplantations in the Unites States found major advances in the procedure and candidate selection for liver transplantation.
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Group 3 ILCs: Peacekeepers or Troublemakers? What's Your Gut Telling You?!
Eirini Pantazi,Nick Powell +1 more
TL;DR: Current knowledge of group 3 ILCs and their contributions to intestinal homeostasis and disease leading to novel therapeutic targets and clinical approaches that may inform novel treatment strategies for immune-mediated disorders, including IBD are discussed.
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Mitochondrial dysfunction governs immunometabolism in leukocytes of patients with acute-on-chronic liver failure.
Ingrid W. Zhang,Anna Curto,Cristina López-Vicario,Mireia Casulleras,Marta Duran-Güell,Roger Flores-Costa,Benoit Colsch,Ferran Aguilar,Ana M. Aransay,Juan José Lozano,María Hernández-Tejero,David Toapanta,Javier Fernández,Vicente Arroyo,Joan Clària +14 more
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NADPH oxidase depletion in neutrophils from patients with cirrhosis and restoration via toll-like receptor 7/8 activation
Loïc Rolas,Abdelali Boussif,Emmanuel Weiss,Philippe Lettéron,Oualid Haddad,Jamel El-Benna,Pierre-Emmanuel Rautou,Richard Moreau,Axel Périanin +8 more
TL;DR: Impairment of neutrophil oxidants production in alcoholic cirrhosis is associated with NOX2 degradation and deficient mTOR-dependent translational machinery and can be reversed via TRL7/8 activation and might be used to restore antimicrobial responses of immunocompromised patients.
Journal ArticleDOI
Liver Transplantation in Acute-on-chronic Liver Failure.
TL;DR: The role of LT is summarized, current prognostic scores in ACLF are highlighted, and potential opportunities to improve outcomes are explored including current care gaps and unmet research needs.