Journal ArticleDOI
Improving the API dissolution rate during pharmaceutical hot-melt extrusion I: Effect of the API particle size, and the co-rotating, twin-screw extruder screw configuration on the API dissolution rate.
TLDR
Analyses of samples indicate that reduction of particle size of theAPI and appropriate selection of screw design can markedly improve the dissolution rate of the API during extrusion.About:
This article is published in International Journal of Pharmaceutics.The article was published on 2015-01-15. It has received 41 citations till now. The article focuses on the topics: Extrusion & Particle size.read more
Citations
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Journal ArticleDOI
Advanced pharmaceutical applications of Hot-Melt Extrusion coupled with Fused Deposition Modelling (FDM) 3D printing for personalised drug delivery
TL;DR: The working principle of Hot Melt Extrusion and Fused Deposition Modelling is reviewed, and how these two technologies can be combined for the use of advanced pharmaceutical applications are reviewed.
Journal ArticleDOI
Melt extrusion with poorly soluble drugs – An integrated review
Michael A. Repka,Suresh Bandari,Venkata Raman Kallakunta,Anh Q. Vo,Haley McFall,Manjeet B. Pimparade,Ajinkya M. Bhagurkar +6 more
TL;DR: This review is focused on the recent reports on the solubility enhancement via HME and provides an update for the manufacturing/scaling up aspects of melt extrusion and analyzes the strengths, weaknesses, opportunities and threats of HME application in the pharmaceutical industry.
Journal ArticleDOI
The application of temperature-composition phase diagrams for hot melt extrusion processing of amorphous solid dispersions to prevent residual crystallinity
Dana E. Moseson,Lynne S. Taylor +1 more
TL;DR: In this article, the authors apply the temperature-composition phase diagram to the HME process, correlating process conditions to ASD residual crystallinity, and identifying the formulation critical temperature, which defines the theoretical minimum processing temperature.
Journal ArticleDOI
Solubility and dissolution enhancement of efavirenz hot melt extruded amorphous solid dispersions using combination of polymeric blends: A QbD approach.
TL;DR: The optimized ASDs batch were stable at 40°C, 75% RH for a period of 6months without any dissolution rate changes, and remained into amorphous state, according to observations inferred from DSC, XRD and in vitro dissolution studies.
References
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Book
Principles of polymer processing
Zehev Tadmor,Costas G. Gogos +1 more
TL;DR: In this paper, the authors present an overview of the history of the field of polymers in terms of elementary steps and shaping methods, and present and future perspectives of this field.
Journal ArticleDOI
Pharmaceutical Applications of Hot-Melt Extrusion: Part I
Michael M. Crowley,Feng Zhang,Michael A. Repka,Sridhar Thumma,Sampada B. Upadhye,Sunil Kumar Battu,James W. McGinity,Charles R. Martin +7 more
TL;DR: The pharmaceutical applications of hot-melt extrusion, including equipment, principles of operation, and process technology, are reviewed and the physicochemical properties of the resultant dosage forms are described.
Journal ArticleDOI
A century of dissolution research: from Noyes and Whitney to the biopharmaceutics classification system.
TL;DR: In this paper, a review of the most important developments in the field of drug dissolution from a historical point of view is presented, which is structured in a chronological order, from the theoretical foundations of dissolution, developed in the first half of the 20th century, and the development of a relationship between dissolution and bioavailability in the 1950s, going to the more recent development in the framework of the Biopharmaceutics Classification System (BCS).
Historical Perspectives A century of dissolution research: From Noyes and Whitney to the Biopharmaceutics Classification System
TL;DR: This review attempts to account the most important developments in the field of dissolution research, from a historical point of view, in the framework of the Biopharmaceutics Classification System (BCS).