In Vitro Evaluation of Kaempferol-Loaded Hydrogel as pH-Sensitive Drug Delivery Systems
Qin Zhang,Xinying Yang,Yifang Wu,Chang Liu,Hongmei Xia,Xi Tao Cheng,Yongfeng Cheng,Ying Xia,Yu Wang +8 more
Reads0
Chats0
TLDR
Kaempferol-loaded carbopol polymer (acrylic acid) hydrogel and its preparations had high antioxidant activity and showed greater swelling and drug release at higher pH values.Abstract:
The purpose of this study was to prepare and evaluate kaempferol-loaded carbopol polymer (acrylic acid) hydrogel, investigate its antioxidant activity in vitro, and compare the effects on drug release under different pH conditions. Drug release studies were conducted in three different pH media (pH 3.4, 5.4, and 7.4). The kaempferol-loaded hydrogel was prepared by using carbopol 934 as the hydrogel matrix. The morphology and viscosity of the preparation were tested to understand the fluidity of the hydrogel. The antioxidant activity of the preparation was studied by scavenging hydrogen peroxide and 2,2-diphenyl-1-picrilhidrazil (DPPH) radicals in vitro and inhibiting the production of malondialdehyde in mouse tissues. The results showed that kaempferol and its preparations had high antioxidant activity. In vitro release studies showed that the drug release at pH 3.4, 5.4, and 7.4 was 27.32 ± 3.49%, 70.89 ± 8.91%, and 87.9 ± 10.13%, respectively. Kaempferol-loaded carbopol hydrogel displayed greater swelling and drug release at higher pH values (pH 7.4).read more
Citations
More filters
Journal ArticleDOI
The Fabrication of Docetaxel-Containing Emulsion for Drug Release Kinetics and Lipid Peroxidation
Yifang Wu,Mengmeng Wang,Yufan Li,Hongmei Xia,Yongfeng Cheng,Chang Liu,Ying Xia,Yu Wang,Yan Yu,Xi Tao Cheng,Zili Xie +10 more
TL;DR: A biocompatible and slow-release DTX-containing emulsion via self-assembly prepared by a high-speed electric stirring method and optimized the formulation could maintain and even enhance the antioxidant effect, both scavenging free radicals in vitro and inhibiting the process of lipid peroxidation.
Journal ArticleDOI
Efficacy of Graphene-Based Nanocomposite Gels as a Promising Wound Healing Biomaterial
D. K. Shanmugam,Yasasve Madhavan,Aashabharathi Manimaran,Gobi Saravanan Kaliaraj,Karthikeyan Mohanraj,Narthana Kandhasamy,Kamalan Kirubaharan Amirtharaj Mosas +6 more
TL;DR: In this article , the synthesis, characterization, and angiogenic properties of graphene-based nanocomposite gels have been corroborated and substantiated through several in vitro and in vivo assays.
Journal ArticleDOI
<i>In vitro</i> and <i>Ex vivo</i> Antioxidant Activity and Sustained Release Properties of Sinomenine-Loaded Liposomes-in-Hydrogel Biomaterials Simulating Cells-in-Extracellular Matrix
Hongmei Xia,Jean Struys +1 more
TL;DR: In this paper , the basic characteristics, In vitro and Ex vivo release, and antioxidant activity of SIN-loaded liposomes-in-hydrogels were studied, and the results showed that SINloaded LINs have good sustained-release and antioxidant effects.
Journal ArticleDOI
Polymeric Gel Systems Cytotoxicity and Drug Release as Key Features for their Effective Application in Various Fields of Addressed Pharmaceuticals Delivery
TL;DR: In this article , a review of gels based on synthetic and natural polymers intended for pharmaceutical-targeted drug delivery in the field of therapy of inflammatory and infectious diseases, dentistry, ophthalmology, oncology, dermatology, rheumatology, neurology, and the treatment of intestinal diseases is presented.
Journal ArticleDOI
Design and Evaluation of Paeonol-Loaded Liposomes in Thermoreversible Gels for Atopic Dermatitis
Yu Wang,Yan Yu,Ruoyang Jia,Xinyi Liu,Zhiqing Cheng,Yongfeng Cheng,Yinxiang Xu,Zili Xie,Hongmei Xia +8 more
TL;DR: In this paper , the authors encapsulated paeonol in a lipid bilayer of liposomes (PAE-L), which delayed drug release and increased drug solubility.
References
More filters
Journal ArticleDOI
Modeling and comparison of dissolution profiles.
TL;DR: Drug dissolution from solid dosage forms has been described by kinetic models in which the dissolved amount of drug (Q) is a function of the test time, t or Q=f(t).
Journal ArticleDOI
Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal.
TL;DR: This review focuses on biochemical concepts of lipidPeroxidation, production, metabolism, and signaling mechanisms of two main omega-6 fatty acids lipid peroxidation products: malondialdehyde (MDA) and, in particular, 4-hydroxy-2-nonenal (4-HNE), summarizing not only its physiological and protective function as signaling molecule stimulating gene expression and cell survival, but also its cytotoxic role inhibiting geneexpression and promoting cell death.
Journal ArticleDOI
Assessment of lipid peroxidation by measuring malondialdehyde (MDA) and relatives in biological samples: Analytical and biological challenges
TL;DR: In this paper, the authors reviewed reported analytical methods and their principles for the quantitative measurement of MDA, HNE and 15(S)-8-iso-PGF2α in biological samples including plasma and urine, and critically discusses their biological and biomedical outcome which is rarely crystal clear and free of artefacts.
Journal ArticleDOI
Bioactive flavonoids in medicinal plants: Structure, activity and biological fate.
TL;DR: A review of relationships between structure, activity, and pharmacokinetics of bioactive flavonoids is presented in this article, which attempts to bring some order into relationship between structure and activity.
Journal ArticleDOI
Kaempferol and inflammation: From chemistry to medicine.
Kasi Pandima Devi,Dicson Sheeja Malar,Seyed Fazel Nabavi,Antoni Sureda,Jianbo Xiao,Seyed Mohammad Nabavi,Maria Daglia +6 more
TL;DR: The present review is aimed to provide a critical overview on the anti-inflammatory effects and the mechanisms of action of kaempferol, based on the current scientific literature, and emphasis is also given on the chemistry, natural sources, bioavailability and toxicity of ka Kempferol.