Journal ArticleDOI
In Vivo Magnetic Resonance Spectroscopy in Cancer
Robert J. Gillies,David L. Morse +1 more
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TLDR
Tissue choline has proven to be a tumor biomarker that is significantly affected by anticancer therapies and is focused on in this review on the latter applications of in vivo MRS.Abstract:
Magnetic resonance spectroscopy (MRS) has been used for more than two decades to interrogate metabolite distributions in living cells and tissues. Techniques have been developed that allow multiple spectra to be obtained simultaneously with individual volume elements as small as 1 uL of tissue (i.e., 1 x 1 x 1 mm(3)). The most common modern applications of in vivo MRS use endogenous signals from (1)H, (31)P, or (23)Na. Important contributions have also been made using exogenous compounds containing (19)F, (13)C, or (17)O. MRS has been used to investigate cardiac and skeletal muscle energetics, neurobiology, and cancer. This review focuses on the latter applications, with specific reference to the measurement of tissue choline, which has proven to be a tumor biomarker that is significantly affected by anticancer therapies.read more
Citations
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Analysis of Cancer Metabolism by Imaging Hyperpolarized Nuclei: Prospects for Translation to Clinical Research
John Kurhanewicz,Daniel B. Vigneron,Kevin M. Brindle,Eduard Y. Chekmenev,Arnaud Comment,Charles H. Cunningham,Ralph J. DeBerardinis,Gary G. R. Green,Martin O. Leach,Sunder S. Rajan,Rahim R. Rizi,Brian D. Ross,Warren S. Warren,Craig R. Malloy +13 more
TL;DR: The known abnormalities in cancer metabolism, the value and limitations of current imaging methods for metabolism, and the principles of hyperpolarization are summarized.
Journal ArticleDOI
Imaging and cancer: A review
Leonard Fass,Leonard Fass +1 more
TL;DR: Targeted imaging and therapeutic agents will be developed in tandem through close collaboration between academia and biotechnology, information technology and pharmaceutical industries to improve outcome and reduce collateral effects.
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Radiation-induced brain injury: A review
Dana Greene-Schloesser,Mike E. Robbins,Ann M. Peiffer,Edward G. Shaw,Kenneth T. Wheeler,Michael D. Chan +5 more
TL;DR: There is a critical need to investigate the microanatomic and functional effects of radiation in various brain regions as well as their integration at clinically relevant doses and schedules.
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Tumor pH and its measurement
TL;DR: This review focuses on the most recent advances in the in vivo measurement of tumor pH by pH-sensitive PET radiotracers, MR spectroscopy, MRI, and optical imaging.
Journal ArticleDOI
New approaches for imaging tumour responses to treatment.
TL;DR: Non-invasive techniques for imaging tissue function that can give early evidence of response to treatment can be used in clinical trials of new drugs to give an early indication of drug efficacy, and subsequently in the clinic to select the most effective therapy at an early stage of treatment.
References
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TL;DR: Proton NMR chemical shift and J‐coupling values are presented for 35 metabolites that can be detected by in vivo or in vitro NMR studies of mammalian brain, with an accuracy suitable for computer simulation of metabolite spectra to be used as basis functions of a parametric spectral analysis procedure.
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NMR chemical shift imaging in three dimensions
TL;DR: A method for obtaining the three-dimensional distribution of chemical shifts in a spatially inhomogeneous sample using Fourier transform NMR is presented and an estimated signal/noise ratio of 20 in 10 min is obtained.
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The Return of the Frequency Sweep: Designing Adiabatic Pulses for Contemporary NMR
Michael Garwood,Lance DelaBarre +1 more
TL;DR: The classical adiabatic rapid passage is analyzed using vector models in different rotating frames of reference and ways to tailor modulation functions to best satisfy specific experimental needs are demonstrated.
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Image-selected in Vivo spectroscopy (ISIS). A new technique for spatially selective nmr spectroscopy
TL;DR: In this article, a spatial localization method for in vivo spectroscopic investigation of biological and medical samples is described, which overcomes most of the technical problems associated with localized NMR spectroscopy and allows the spectrum to be investigated from a cube which can be positioned by reference to an NMR image.