Journal ArticleDOI
Increased 4-hydroxynonenal levels in experimental alcoholic liver disease: association of lipid peroxidation with liver fibrogenesis.
Seiichiro Kamimura,Karl Gaal,Karl Gaal,Robert S. Britton,Bruce R. Bacon,George Triadafilopoulos,George Triadafilopoulos,Hidekazu Tsukamoto,Hidekazu Tsukamoto,Hidekazu Tsukamoto +9 more
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TLDR
Dissociation between the initiation of alcoholic liver necrosis and enhanced lipid peroxidation is demonstrated, association of enhanced lipidPeroxidation with liver fibrogenesis and depressed antioxidant system is association, and the first demonstration of increased 4‐hydroxynonenal level in experimental alcoholic liver disease is demonstrated.About:
This article is published in Hepatology.The article was published on 1992-08-01. It has received 215 citations till now. The article focuses on the topics: Alcoholic liver disease & Lipid peroxidation.read more
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Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver
TL;DR: The hepatic stellate cell has surprised and engaged physiologists, pathologists, and hepatologists for over 130 years, yet clear evidence of its role in hepatic injury and fibrosis only emerged following the refinement of methods for its isolation and characterization.
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Independent predictors of liver fibrosis in patients with nonalcoholic steatohepatitis
TL;DR: Older age, obesity, and presence of diabetes mellitus help identify those NASH patients who might have severe liver fibrosis, and this is the subgroup of patients who would be expected to derive the most benefit from having a liver biopsy and considering investigational therapies.
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The Cellular Basis of Hepatic Fibrosis -- Mechanisms and Treatment Strategies
TL;DR: Advances in the isolation and characterization of liver cells, in conjunction with progress in matrix and cytokine biology, have led to important new insights about the cellular basis of hepatic fibrosis, including the hepatic lipocyte.
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Fibrosis in chronic hepatitis C correlates significantly with body mass index and steatosis
Luke F. Hourigan,Graeme A. Macdonald,David M. Purdie,Vicki H. Whitehall,Claudia Shorthouse,Andrew D. Clouston,Elizabeth E. Powell +6 more
TL;DR: It is suggested that increasing body mass index has a role in the pathogenesis of steatosis in chronic hepatitis C and that Steatosis may contribute to fibrosis.
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Pathogenesis of liver fibrosis: role of oxidative stress.
TL;DR: Reactive oxidant species likely contribute to both onset and progression of fibrosis as induced by alcohol, viruses, iron or copper overload, cholestasis, hepatic blood congestion and many if not all chronic disease processes affecting hepatic tissue.
References
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Journal ArticleDOI
A rapid method of total lipid extraction and purification.
E. G. Bligh,W. J. Dyer +1 more
TL;DR: The lipid decomposition studies in frozen fish have led to the development of a simple and rapid method for the extraction and purification of lipids from biological materials that has been applied to fish muscle and may easily be adapted to use with other tissues.
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Determination of malonaldehyde precursor in tissues by thiobarbituric acid test
Mitsuru Uchiyama,Midori Mihara +1 more
TL;DR: It was concluded that the deproteinization of homogenate prior to coloration is not needed, but double wavelength measurement is necessary to avoid interference and the reaction should be performed with phosphoric acid at a definite pH near 2.0.
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Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine
TL;DR: It is reported here that 2-vinylpyridine is a much better reagent for the derivitization of glutathione, and it is demonstrated that the total glutATHione concentration in mouse plasma is substantially higher than generally reported and that glutathion disulfide constitutes less than 30% of the totalglutathione present.
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Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man.
Seppo Ylä-Herttuala,Wulf Palinski,Michael E. Rosenfeld,Sampath Parthasarathy,Thomas E. Carew,Susan Butler,Joseph L. Witztum,Daniel Steinberg +7 more
TL;DR: Three lines of evidence are presented that low density lipoproteins gently extracted from human and rabbit atherosclerotic lesions (lesion LDL) greatly resembles LDL that has been oxidatively modified in vitro.