Journal ArticleDOI
Increased genetic risk or protection for canine autoimmune lymphocytic thyroiditis in Giant Schnauzers depends on DLA class II genotype.
Maria Wilbe,Katarina Sundberg,I. R. Hansen,Erling Strandberg,R. F. Nachreiner,Åke Hedhammar,Lorna J. Kennedy,Göran Andersson,S. Björnerfeldt +8 more
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TLDR
Evidence is obtained that dog leukocyte antigen (DLA) class II genotype function as either genetic risk factor that predisposes for CLT or as protective factor against the disease.Abstract:
Dogs represent an excellent comparative model for autoimmune thyroiditis as several dog breeds develop canine lymphocytic thyroiditis (CLT), which is clinically similar to Hashimoto's thyroiditis in human. We obtained evidence that dog leukocyte antigen (DLA) class II genotype function as either genetic risk factor that predisposes for CLT or as protective factor against the disease. Genetic diversity at their DLA-DRB1, -DQA1, and -DQB1 loci were defined and potential association to major histocompatibility complex II haplotypes and alleles was analyzed. Giant Schnauzers carrying the DLA-DRB1*01201/DQA1*00101/DQB1*00201 haplotype showed an increased risk (odds ratio of 6.5) for developing CLT. The same risk haplotype has, to date, been observed in three different breeds affected by this disease, Giant Schnauzer, Dobermann, and Labrador Retriever, indicating that it is a common genetic risk factor in a variety of breeds affected by this disease. Importantly, protection for development of the disease was found in dogs carrying the DLA-DRB1*01301/DQA1*00301/DQB1*00501 haplotype (odds ratio of 0.3).read more
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Canine hypothyroidism: a review of aetiology and diagnosis.
TL;DR: The development of newer diagnostic tests has significantly improved the ability to reliably differentiate hypothyroidism from other clinically similar disorders, which has led to a marked increase in knowledge of the phenotypic, genotypic and aetiological aspects of this disorder in dogs.
Journal ArticleDOI
Expanded dog leukocyte antigen (DLA) single nucleotide polymorphism (SNP) genotyping reveals spurious class II associations
Noa Safra,Niels C Pedersen,Zena T. Wolf,Eric G. Johnson,Hongwei Liu,Angela M. Hughes,Amy E. Young,Danika L. Bannasch +7 more
TL;DR: A genotyping assay of 126 coding single nucleotide polymorphisms (SNPs) from across the entire DLA, spanning a region of 2.5 Mb, was developed and tested on Weimaraners with HOD, as well as two additional breeds with diseases associated with DLA class II: Nova Scotia duck tolling retrievers with hypoadrenocorticism and Pug dogs with NME.
Journal ArticleDOI
MHC class II association study in eight breeds of dog with hypoadrenocorticism.
Jonathan Massey,Alisdair Boag,Andrea D. Short,Rachel Scholey,Paula S. Henthorn,Meryl P. Littman,Eystein S. Husebye,Eystein S. Husebye,Brian Catchpole,Niels C Pedersen,Cathryn S. Mellersh,William E R Ollier,Lorna J. Kennedy +12 more
TL;DR: Significant differences in dog leukocyte antigen (DLA) haplotype frequencies in six breeds of dog with diagnoses of hypoadrenocorticism are demonstrated, which may suggest that the gene of interest is closely linked to the MHC.
Journal ArticleDOI
MHC class II risk haplotype associated with canine chronic superficial keratitis in German Shepherd dogs.
TL;DR: This study identifies a MHC class II risk haplotype for CSK in GSD and further supports the autoimmune origin of the disease.
Journal ArticleDOI
Alleles of the major histocompatibility complex play a role in the pathogenesis of pancreatic acinar atrophy in dogs.
Kate L. Tsai,Alison N. Starr-Moss,Gopalakrishnan M. Venkataraman,Christopher Robinson,Lorna J. Kennedy,Jörg M. Steiner,Leigh Anne Clark +6 more
TL;DR: Genotyping of MHC class I and II loci in a GSD cohort, establishment of four-locus haplotypes, and association of alleles/haplotypes with EPI are described.
References
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Journal ArticleDOI
Genome sequence, comparative analysis and haplotype structure of the domestic dog
Kerstin Lindblad-Toh,Claire M. Wade,Claire M. Wade,Tarjei S. Mikkelsen,Tarjei S. Mikkelsen,Elinor K. Karlsson,Elinor K. Karlsson,David B. Jaffe,Michael Kamal,Michele Clamp,Jean L. Chang,Edward J. Kulbokas,Michael C. Zody,Evan Mauceli,Xiaohui Xie,Matthew Breen,Robert K. Wayne,Elaine A. Ostrander,Chris P. Ponting,Francis Galibert,Douglas Smith,Pieter J. deJong,Ewen F. Kirkness,Pablo Alvarez,Tara Biagi,William Brockman,Jonathan Butler,Chee-Wye Chin,April Cook,James Cuff,Mark J. Daly,Mark J. Daly,David DeCaprio,Sante Gnerre,Manfred Grabherr,Manolis Kellis,Michael Kleber,Carolyne Bardeleben,Leo Goodstadt,Andreas Heger,Christophe Hitte,Lisa Kim,Klaus-Peter Koepfli,Heidi G. Parker,John P. Pollinger,Stephen M. J. Searle,Nathan B. Sutter,Rachael Thomas,Caleb Webber,Jennifer Baldwin,Jennifer Baldwin,Adal Abebe,Amr Abouelleil,Lynne Aftuck,Mostafa Ait-zahra,Tyler Aldredge,Nicole R. Allen,Peter An,Scott Anderson,Claudel Antoine,Harindra Arachchi,Ali Aslam,Laura Ayotte,Pasang Bachantsang,Andrew Barry,Tashi Bayul,Mostafa Benamara,Aaron M. Berlin,Daniel Bessette,Berta Blitshteyn,Toby Bloom,Jason Blye,Leonid Boguslavskiy,Claude Bonnet,Boris Boukhgalter,Adam Brown,Patrick Cahill,Nadia Calixte,Jody Camarata,Yama Cheshatsang,Jeffrey Chu,Mieke Citroen,Alville Collymore,Patrick Cooke,Tenzin Dawoe,Riza M. Daza,Karin Decktor,Stuart DeGray,Norbu Dhargay,Kimberly Dooley,Kathleen Dooley,Passang Dorje,Kunsang Dorjee,Lester Dorris,Noah Duffey,Alan Dupes,Osebhajajeme Egbiremolen,Richard Elong,Jill Falk,Abderrahim Farina,Susan Faro,Diallo Ferguson,Patricia Ferreira,Sheila A. Fisher,Michael Fitzgerald,Karen Foley,Chelsea D. Foley,Alicia Franke,Dennis C. Friedrich,Diane Gage,Manuel Garber,Gary Gearin,Georgia Giannoukos,Tina Goode,Audra Goyette,Joseph Graham,Edward Grandbois,Kunsang Gyaltsen,Nabil Hafez,Daniel S. Hagopian,Birhane Hagos,Jennifer Ruth Sadler Hall,Claire M. Healy,Ryan Hegarty,Tracey Honan,Andrea Horn,Nathan Houde,Leanne Hughes,Leigh Anne Hunnicutt,M. Husby,Benjamin Jester,Charlien Jones,Asha Kamat,Ben Kanga,Cristyn Kells,Dmitry Khazanovich,Alix Chinh Kieu,Peter Kisner,Mayank Kumar,Krista Lance,Thomas E. Landers,Marcia Lara,William H. Lee,Jean-Pierre Leger,Niall J. Lennon,Lisa Leuper,Sarah LeVine,Jinlei Liu,Xiaohong Liu,Yeshi Lokyitsang,Tashi Lokyitsang,Annie Lui,Jan Macdonald,John E. Major,Richard Marabella,Kebede Maru,Charles Matthews,Susan McDonough,Teena Mehta,James Meldrim,Alexandre Melnikov,Louis Meneus,Atanas Mihalev,Tanya Mihova,Karen Hughes Miller,Rachel Mittelman,Valentine Mlenga,Leonidas Mulrain,Glen Munson,Adam Navidi,Jerome Naylor,Tuyen T. Nguyen,Nga Nguyen,Cindy Nguyen,Thu Nguyen,Robert Nicol,Nyima Norbu,Choe Norbu,Nathaniel Novod,Tenchoe Nyima,Peter Olandt,Barry O'Neill,Keith O'Neill,Sahal Osman,Lucien Oyono,Christopher Patti,Danielle Perrin,Pema Phunkhang,Fritz Pierre,Margaret Priest,Anthony Rachupka,Sujaa Raghuraman,Rayale Rameau,Verneda Ray,Christina Raymond,Filip Rege,Cecil Rise,Julie Rogers,Peter Rogov,Julie Sahalie,Sampath Settipalli,Ted Sharpe,Terrance Shea,Mechele Sheehan,Ngawang Sherpa,Jianying Shi,Diana M. Shih,Jessie Sloan,Cherylyn Smith,Todd Sparrow,John Stalker,Nicole Stange-Thomann,Sharon Stavropoulos,Catherine Stone,Sabrina M. Stone,Sean M. Sykes,Pierre Tchuinga,Pema Tenzing,Senait Tesfaye,Dawa Thoulutsang,Yama Thoulutsang,Kerri Topham,Ira Topping,Tsamla Tsamla,Helen Vassiliev,Vijay Venkataraman,Andy Vo,Tsering Wangchuk,Tsering Wangdi,Michael Weiand,Jane E. Wilkinson,Adam Wilson,Shailendra Yadav,Shuli Yang,Xiaoping Yang,Geneva Young,Qing Yu,Joanne Zainoun,Lisa Zembek,Andrew Zimmer,Eric S. Lander,Eric S. Lander +241 more
TL;DR: A high-quality draft genome sequence of the domestic dog is reported, together with a dense map of single nucleotide polymorphisms (SNPs) across breeds, to shed light on the structure and evolution of genomes and genes.
Journal ArticleDOI
Efficient mapping of mendelian traits in dogs through genome-wide association.
Elinor K. Karlsson,Elinor K. Karlsson,Izabella Baranowska,Claire M. Wade,Claire M. Wade,Nicolette Salmon Hillbertz,Michael C. Zody,Nathan Anderson,Tara M Biagi,Nick Patterson,Gerli Pielberg,Edward J. Kulbokas,Kenine E. Comstock,Evan T. Keller,Jill P. Mesirov,Jill P. Mesirov,Henrik von Euler,Olle Kämpe,Åke Hedhammar,Eric S. Lander,Göran Andersson,Leif Andersson,Leif Andersson,Kerstin Lindblad-Toh,Kerstin Lindblad-Toh +24 more
TL;DR: The development of a genotyping array with ∼27,000 SNPs is reported and it is shown that genome-wide association mapping of mendelian traits in dog breeds can be achieved with only ∼20 dogs, showing that trait mapping within dog breeds will be highly efficient and generally applicable to trait mapping.
Journal ArticleDOI
HLA-DRB1 polymorphism determines susceptibility to autoimmune thyroiditis in transgenic mice: Definitive association with HLA-DRB1*0301 (DR3) gene
Yi Chi M. Kong,Lesley Lomo,Reinhard W. Motte,Alvaro A. Giraldo,Jean Baisch,Gudrun Strauss,Gunter J. Hämmerling,Chella S. David +7 more
TL;DR: It is shown that HLA-DRB1 polymorphism determines susceptibility to autoimmune thyroiditis and implicate Tg as an important autoantigen.
Journal ArticleDOI
Genetics of autoimmune thyroid disease: lack of evidence for linkage to HLA within families.
TL;DR: Whereas there is an association of AITD with the HLA region, linkage analysis demonstrates that alleles of the Hla region are not cosegregating with either GD or HT within these families, whereas HLA may increase susceptibility to AITd, as shown by the existence of an HLA association, the major genetic influence on the inheritance of AITS must be at another locus.
Journal ArticleDOI
Nomenclature for factors of the dog major histocompatibility system (DLA), 2000: Second report of the ISAG DLA Nomenclature Committee
Lorna J. Kennedy,J. M. Angles,A. Barnes,Stuart D. Carter,Olga Francino,J. A. Gerlach,George M. Happ,William Ernest Royce Ollier,Wendy Thomson,John L. Wagner +9 more
TL;DR: A Nomenclature Committee for factors of the dog major histocompatibility system or dog leukocyte antigen (DLA) has been convened under the auspices of the International Society for Animal Genetics (ISAG) to define a sequence-based nomenclatures for the genes of the DLA system as discussed by the authors.