Increased risk of non-insulin dependent diabetes mellitus, arterial hypertension and coronary artery disease in perimenopausal women with a history of the polycystic ovary syndrome
TLDR
Women in the general population have the same level of risk factors at perimenopausal age as PCOS women, and patients with markedly expressed clinical symptoms of PCOS made up a subgroup in thegeneral population at high risk for developing NIDDM and coronary artery disease.Abstract:
The aim of the study was to determine the prevalence of non-insulin dependent diabetes mellitus (NIDDM), arterial hypertension, coronary artery disease and the risk factors for these diseases in perimenopausal women with a history of polycystic ovary syndrome (PCOS) treatment A group of 28 women was selected from a large group of patients who had undergone wedge ovarian resection A total of 752 controls was selected by age (45-59 years) from a random female population sample There was no difference between the two groups in body mass index, waist circumference or waist-hip ratio Both groups were found to have identical family histories of NIDDM, hypertension, and coronary artery disease and identical smoking habits We did not find a difference between the mean concentrations of lipids and fasting glucose The two groups did not differ in the proportions of women with elevated lipid concentrations The prevalence of NIDDM and coronary artery disease was significantly higher in PCOS women In conclusion, women in the general population have the same level of risk factors at perimenopausal age as PCOS women Patients with markedly expressed clinical symptoms of PCOS made up a subgroup in the general population at high risk for developing NIDDM and coronary artery diseaseread more
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Consensus on women's health aspects of polycystic ovary syndrome (PCOS): The Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop Group
Bart C.J.M. Fauser,Basil C. Tarlatzis,Robert W. Rebar,Richard S. Legro,Adam H. Balen,Roger A. Lobo,Enrico Carmina,Jeffrey P. Chang,Bulent O. Yildiz,Joop S.E. Laven,Jacky Boivin,Felice Petraglia,C. N. Wijeyeratne,Robert J. Norman,Andrea Dunaif,Stephen Franks,Robert A. Wild,Daniel A. Dumesic,Kurt T. Barnhart +18 more
TL;DR: Relevant topics addressed-all dealt with in a systematic fashion-include adolescence, hirsutism and acne, contraception, menstrual cycle abnormalities, quality of life, ethnicity, pregnancy complications, long-term metabolic and cardiovascular health, and finally cancer risk.
Journal ArticleDOI
Polycystic ovary syndrome.
Ricardo Azziz,Enrico Carmina,Zi-Jiang Chen,Andrea Dunaif,Joop S.E. Laven,Richard S. Legro,Daria Lizneva,Daria Lizneva,Barbara Natterson-Horowtiz,Helena J. Teede,Bulent O. Yildiz +10 more
TL;DR: PCOS can impact women’s reproductive health, leading to anovulatory infertility and higher rate of early pregnancy loss, and the risks of diabetes, cardiovascular disease, hypertension, metabolic syndrome, and endometrial cancer among PCOS patients are significantly increased.
Journal ArticleDOI
Polycystic ovary syndrome: etiology, pathogenesis and diagnosis
TL;DR: Treatment of PCOS is focused on the goals of ameliorating hyperandrogenic symptoms, inducing ovulation and preventing cardiometabolic complications, and ruling out other hyper androgenic or oligo-ovulatory disorders.
Journal ArticleDOI
Impaired glucose tolerance, type 2 diabetes and metabolic syndrome in polycystic ovary syndrome: a systematic review and meta-analysis
TL;DR: Women with PCOS had an elevated prevalence of IGT, DM2 and metabolic syndrome in both BMI and non-BMI-matched studies and further research is required.
Journal ArticleDOI
Assessment of Cardiovascular Risk and Prevention of Cardiovascular Disease in Women with the Polycystic Ovary Syndrome: A Consensus Statement by the Androgen Excess and Polycystic Ovary Syndrome (AE-PCOS) Society
Robert A. Wild,Enrico Carmina,Evanthia Diamanti-Kandarakis,Anuja Dokras,Héctor F. Escobar-Morreale,Walter Futterweit,Rogerio A. Lobo,Robert J. Norman,Evelyn O. Talbott,Daniel A. Dumesic +9 more
TL;DR: An expert panel in PCOS and CVD reviewed literature and presented recommendations, finding women with PCOS with obesity, cigarette smoking, dyslipidemia, hypertension, impaired glucose tolerance, and subclinical vascular disease are at risk, whereas those with metabolic syndrome and/or type 2 diabetes mellitus are at high risk for CVD.
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