Journal ArticleDOI
Indium 111 ZCE-025 immunoscintigraphy in occult recurrent colorectal cancer with elevated carcinoembryonic antigen level.
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TLDR
The accurate localization of colorectal carcinoma recurrences by means of 111In ZCE-025 monoclonal antibody demonstrates the usefulness of this diagnostic agent in the setting of elevated carcinoembryonic antigen level and negative results of clinical and radiologic workup.Abstract:
• We investigated the utility of scanning with indium 111 labeled to monoclonal antibody in 13 patients after curative resection of colorectal cancer who had elevated carcinoembryonic antigen levels and negative results of clinical workup. Each patient received 1 mg of anti–carcinoembryonic antigen monoclonal antibody type ZCE 025 labeled with 5.5 mCi of111In, plus 9 to 39 mg of the same antibody unlabeled. Patients underwent scanning 3 to 7 days after infusion by planar and emission computed tomography. ZCE-025 monoclonal antibody imaging detected tumor recurrence or metastasis in 11 of 13 patients. In one patient the monoclonal antibody scan gave a true-negative result, and in one patient the monoclonal antibody scan failed to disclose a metachronous cecal primary. Tumor sites identified were the pelvis (2 patients), abdominal wall (2), retroperitoneum (1), lymph nodes (3), liver (2), bone (2), and lung (1). The accurate localization of colorectal carcinoma recurrences by means of111In ZCE-025 monoclonal antibody demonstrates the usefulness of this diagnostic agent in the setting of elevated carcinoembryonic antigen level and negative results of clinical and radiologic workup. (Arch Surg. 1990;125:226-229)read more
Citations
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Journal Article
Safety and role of repeated administrations of Indium-111-labeled anti-carcinoembryonic antigen monoclonal antibody ZCE 025 in the postoperative follow-up of colorectal carcinoma patients.
Hani H. Abdel-Nabi,Ralph J. Doerr,Him-Wing Chan,Elongia Farrell,Nancy H. Evans,Monica B. Spaulding,Sally Schweighardt,E. Bruce Merchant +7 more
TL;DR: It is suggested that a negative Mab scan indicates that a patient will remain free of recurrence; conversely, a positive scan was associated with recurrences of disease.
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Correlative imaging with monoclonal antibodies in colorectal, ovarian, and prostate cancer.
TL;DR: Immunoscintigraphy is being refined and tested to locate bony and soft-tissue metastases in patients with prostate cancer, and in ovarian cancer patients, MoAbs are promising as safe, sensitive imaging tools.
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99mTc-IMMU-4 monoclonal antibody scan in colorectal cancer. A prospective study.
TL;DR: Radioimmunodetection scan was complementary to computed tomographic scan in the examination of patients with colorectal carcinoma in this study, and the sensitivities and specificities were 52%, 86%, and 61% for hepatic, extrahepatic intra-abdominal, and pelvic lesions, respectively.
Journal ArticleDOI
Carcinoembryonic antigen to detect hepatic metastases of colorectal cancers.
TL;DR: The CEA levels in bile, mesenteric venous blood, and peripheral venousBlood were increased in patients with CRC and liver metastases, and the detection of elevated CEA Levels in biles taken at surgery did not herald metachronous hepatic metastases in CRC patients without liver metastase.
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Results of immunoscintigraphy using a cocktail of radiolabeled monoclonal antibodies in the detection of colorectal cancer
TL;DR: The combination of In 111 CYt-103 and CYT-372 improved the sensitivity of external immunoscintigraphy for the detection of colorectal cancer compared to that obtained with a single MoAb imaging.
References
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Journal ArticleDOI
Specific carcinoembryonic antigens of the human digestive system
Phil Gold,Samuel O. Freedman +1 more
TL;DR: It was concluded that the carcinoembryonic antigens represent cellular constituents which are repressed during the course of differentiation of the normal digestive system epithelium and reappear in the corresponding malignant cells by a process of derepressive-dedifferentiation.
Journal ArticleDOI
Use of Radiolabeled Antibodies to Carcinoembryonic Antigen for the Detection and Localization of Diverse Cancers by External Photoscanning
David M. Goldenberg,Frank H. DeLand,E. Edmund Kim,S. Bennett,F J Primus,J.R. van Nagell,N. Estes,P. DeSimone,P. Rayburn +8 more
TL;DR: To determine whether tumors containing carcinoembryonic antigen could be detected by administration of a radiolabeled, affinity-purified, goat lgG, 18 patients with a history of cancer of diverse histopathology received an average total dose of 1.0 mCi of 131l-labeled lGG.
Journal ArticleDOI
Patterns of recurrence following surgery alone for adenocarcinoma of the colon and rectum
TL;DR: Through 5 years, local recurrence without clinical evidence of distant metastases was the most common cause of death and plans for adjuvant radiation therapy are discussed.
Journal ArticleDOI
Covalent attachment of chelating groups to macromolecules.
TL;DR: A simple procedure for covalently coupling diethylenetriaminepentaacetic acid to proteins and creates hexadentate chelating sites for metal ions on proteins is described.
Journal ArticleDOI
Tumor localization of radiolabeled antibodies against carcinoembryonic antigen in patients with carcinoma: a critical evaluation.
TL;DR: Purified, [131I]-labeled goat antibodies against carcinoembryonic antigen, which have been shown to localize in human carcinoma in nude mice, were injected into patients with carcinoma and demonstrated that only the anti-CEA antibodies localized in tumors.
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