Journal ArticleDOI
Indole in the target-based design of anticancer agents: A versatile scaffold with diverse mechanisms.
Sakineh Dadashpour,Saeed Emami +1 more
TLDR
The present article aims to review the current application of indole core in the design of new anticancer agents that may act via various targets such as histone deacetylases, sirtuins, PIM kinases, DNA topoisomerases and σ receptors.About:
This article is published in European Journal of Medicinal Chemistry.The article was published on 2018-04-25. It has received 208 citations till now. The article focuses on the topics: Indole test.read more
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Medicinal chemistry of indole derivatives: Current to future therapeutic prospectives.
Archana Kumari,Rajesh K. Singh +1 more
TL;DR: This review summarizes some of the recent effective chemical synthesis (2014-2018) for indole ring and emphasized on the structure-activity relationship (SAR) to reveal the active pharmacophores of various indole analogues accountable for anticancer, anticonvulsant, antimicrobial, antitubercular, antimalarial, antiviral, antidiabetic and other miscellaneous activities which have been investigated in the last five years.
Journal ArticleDOI
Indole: A privileged scaffold for the design of anti-cancer agents.
TL;DR: This review aimed to provide a clear knowledge on the recent development of indoles as anti-cancer agents, such as myeloid cell leukemia-1 (Mcl-1) inhibitors, proviral insertion site in moloney murine leukemia virus (Pim), and made an insight into the corresponding structure-activity relationships (SARs).
Journal ArticleDOI
Pyrolysis of microalgae: A critical review
Changyan Yang,Changyan Yang,Rui Li,Bo Zhang,Qi Qiu,Baowei Wang,Hui Yang,Yigang Ding,Cunwen Wang +8 more
TL;DR: In this paper, a review of the state-of-the-art developments in the field of microalgae pyrolysis and catalytic catalysts for the selective conversion of micro-algae into fine chemicals is presented.
Journal ArticleDOI
Synthetic heterocyclic candidates as promising α-glucosidase inhibitors: An overview.
Manoj Dhameja,Preeti Gupta +1 more
TL;DR: This review deals with recently discovered heterocyclic molecules that have been evaluated to exhibit inhibition of α-glucosidase enzyme in the treatment of type 2 diabetes mellitus.
Journal ArticleDOI
Ferrocene-containing hybrids as potential anticancer agents: Current developments, mechanisms of action and structure-activity relationships.
TL;DR: This review will provide an overview of ferrocene-containing hybrids with potential application in the treatment of cancers covering articles published between 2010 and 2020.
References
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Global cancer statistics
TL;DR: A substantial proportion of the worldwide burden of cancer could be prevented through the application of existing cancer control knowledge and by implementing programs for tobacco control, vaccination, and early detection and treatment, as well as public health campaigns promoting physical activity and a healthier dietary intake.
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The hallmarks of cancer.
TL;DR: This work has been supported by the Department of the Army and the National Institutes of Health, and the author acknowledges the support and encouragement of the National Cancer Institute.
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Anthracyclines: Molecular Advances and Pharmacologic Developments in Antitumor Activity and Cardiotoxicity
TL;DR: An overview of issues confirms that anthracyclines remain “evergreen” drugs with broad clinical indications but have still an improvable therapeutic index.
Journal ArticleDOI
Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase
Anne Brunet,Lora B. Sweeney,J. Fitzhugh Sturgill,Katrin F. Chua,Paul L. Greer,Yingxi Lin,Hien Tran,Sarah E. Ross,Raul Mostoslavsky,Haim Y. Cohen,Linda Hu,Hwei-Ling Cheng,Mark P. Jedrychowski,Steven P. Gygi,David A. Sinclair,Frederick W. Alt,Michael E. Greenberg +16 more
TL;DR: One way in which members of the Sir2 family of proteins may increase organismal longevity is by tipping FOXO-dependent responses away from apoptosis and toward stress resistance.
Journal ArticleDOI
Modulation of NF-κB-dependent transcription and cell survival by the SIRT1 deacetylase
Fan Yeung,Jamie E. Hoberg,Catherine S. Ramsey,Michael D Keller,David R. Jones,Roy A. Frye,Marty W. Mayo +6 more
TL;DR: It is demonstrated that SIRT1, a nicotinamide adenosine dinucleotide‐dependent histone deacetylase, regulates the transcriptional activity of NF‐κB and activity augments apoptosis in response to TNFα.
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Indoles as therapeutics of interest in medicinal chemistry: Bird's eye view.
Navriti Chadha,Om Silakari +1 more