Induction of hepatitis A virus-neutralizing antibody by a virus-specific synthetic peptide.
Reads0
Chats0
TLDR
A structural homology exists between the two viruses, despite minimal primary sequence conservation, and a synthetic peptide containing the HAV-specific amino acid sequence of one of these sites induced anti-HAV-neutralizing antibodies.Abstract:
Comparative surface feature analyses of the VP1 sequences of hepatitis A virus (HAV) and poliovirus type 1 allowed an alignment of the two sequences and an identification of probable HAV neutralization antigenic sites. A synthetic peptide containing the HAV-specific amino acid sequence of one of these sites induced anti-HAV-neutralizing antibodies. It is concluded that a structural homology exists between the two viruses, despite minimal primary sequence conservation.read more
Citations
More filters
Journal ArticleDOI
Identification and characterization of a gene coding a novel isoform of DEAD-box protein
TL;DR: A gene coding a novel isoform of DEAD-box protein named testicular DEAD- box protein (tDbp), presumably involved in testicular function, was identified and characterized and showed that it was expressed at a higher level in adult testis than in embryo testis.
Book ChapterDOI
Design of a Peptide-Carrier Vaccine Based on the Highly Immunogenic Fasciola hepatica Leucine Aminopeptidase.
TL;DR: The design of a chimeric protein based on the hexamer form of the highly immunogenic Fasciola hepatica leucine aminopeptidase as a carrier system of small peptides with potential use as a multiepitope vaccine is described.
Posted ContentDOI
Computational vaccinology approach: Designing an efficient multi-epitope peptide vaccine against Cryptococcus neoformans var. grubii’s heat shock 70KDa protein
Elhassan Rm,Elhassan Rm,Alsony Nm,Othman Km,Izz-Aldin Dt,Alhaj Ta,Ali Aa,Abashir La,Ahmed Oh,Mohamed A. Hassan +9 more
TL;DR: This study designs a reliable multi-epitope peptide vaccine against highly conserved immunodominant heat shock 70KDa protein of Cryptococcus neoformans var.
Journal Article
Analysis of Structures, Functions, and Epitopes of Aminopeptidase from Trichinella spiralis.
TL;DR: TsAP was a kind of proteolytic enzyme with a variety of biological functions and its antigenic epitopes could provide important insights on the diagnostic antigens and target molecular of anti-Trichinella drugs.
Journal ArticleDOI
Isolation and genome analysis of a lytic Pasteurella multocida Bacteriophage PMP-GAD-IND.
Sabia Qureshi,H.M. Saxena,Nikhat Imam,Zahid Amin Kashoo,M. Sharief Banday,Aftab Alam,Md. Zubbair Malik,Romana Ishrat,Basharat Bhat +8 more
TL;DR: PMP‐GAD‐IND being a lytic phage with broad activity range has a potential to be used in therapy against multidrug resistant P. multocida infections.
References
More filters
Journal ArticleDOI
Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins.
TL;DR: The algorithm is shown to be at least as good as, and usually superior to, the reported prediction methods assessed in the same way and the implication in protein folding is discussed.
Journal ArticleDOI
Prediction of protein antigenic determinants from amino acid sequences.
Thomas P. Hopp,Kenneth R. Woods +1 more
TL;DR: The method was developed using 12 proteins for which extensive immunochemical analysis has been carried out and subsequently was used to predict antigenic determinants for the following proteins, finding that the prediction success rate depended on averaging group length.
Journal ArticleDOI
Solid Phase Peptide Synthesis
TL;DR: This work has shown that effective methods of peptide synthesis are crucial to progress in this area, because only by synthesis can adequate amounts of important peptides be made available for chemical, biologi...
Related Papers (5)
A semi-empirical method for prediction of antigenic determinants on protein antigens
A.S. Kolaskar,Prasad Tongaonkar +1 more
New hydrophilicity scale derived from high-performance liquid chromatography peptide retention data: correlation of predicted surface residues with antigenicity and X-ray-derived accessible sites.
A simple method for displaying the hydropathic character of a protein
Jack Kyte,Russell F. Doolittle +1 more