Induction of hepatitis A virus-neutralizing antibody by a virus-specific synthetic peptide.
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TLDR
A structural homology exists between the two viruses, despite minimal primary sequence conservation, and a synthetic peptide containing the HAV-specific amino acid sequence of one of these sites induced anti-HAV-neutralizing antibodies.Abstract:
Comparative surface feature analyses of the VP1 sequences of hepatitis A virus (HAV) and poliovirus type 1 allowed an alignment of the two sequences and an identification of probable HAV neutralization antigenic sites. A synthetic peptide containing the HAV-specific amino acid sequence of one of these sites induced anti-HAV-neutralizing antibodies. It is concluded that a structural homology exists between the two viruses, despite minimal primary sequence conservation.read more
Citations
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Prediction of antigenic epitopes on protein surfaces by consensus scoring
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Tolerogenic synthetic nanocarriers to reduce immune responses to therapeutic proteins
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Processing of the AIDA-I precursor: removal of AIDAc and evidence for the outer membrane anchoring as a beta-barrel structure.
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TL;DR: Analysis by protease digestion, secondary‐structure prediction and modelling, by comparison with structurally related bacterial proteins like the lgA1 protease from neisseria, the vacuolating toxin from Helicobacter pylori, and the VirG protein of Shigella flexneri, strongly indicates that AIDAC is present in the outer membrane as a β‐barrel structure.
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SLiMDisc: short, linear motif discovery, correcting for common evolutionary descent
TL;DR: The TEIRESIAS algorithm was shown to significantly outperform methods that do not discount evolutionary relatedness, when applied to known SLiMs from a subset of the eukaryotic linear motif (ELM) database, and an implementation of Multiple Spanning Tree weighting outperformed two other weighting schemes, in a variety of settings.
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Identification of two regions within the cytoplasmic domain of the human interferon-gamma receptor required for function.
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References
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TL;DR: The algorithm is shown to be at least as good as, and usually superior to, the reported prediction methods assessed in the same way and the implication in protein folding is discussed.
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Prediction of protein antigenic determinants from amino acid sequences.
Thomas P. Hopp,Kenneth R. Woods +1 more
TL;DR: The method was developed using 12 proteins for which extensive immunochemical analysis has been carried out and subsequently was used to predict antigenic determinants for the following proteins, finding that the prediction success rate depended on averaging group length.
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Solid Phase Peptide Synthesis
TL;DR: This work has shown that effective methods of peptide synthesis are crucial to progress in this area, because only by synthesis can adequate amounts of important peptides be made available for chemical, biologi...
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