Induction of hepatitis A virus-neutralizing antibody by a virus-specific synthetic peptide.
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TLDR
A structural homology exists between the two viruses, despite minimal primary sequence conservation, and a synthetic peptide containing the HAV-specific amino acid sequence of one of these sites induced anti-HAV-neutralizing antibodies.Abstract:
Comparative surface feature analyses of the VP1 sequences of hepatitis A virus (HAV) and poliovirus type 1 allowed an alignment of the two sequences and an identification of probable HAV neutralization antigenic sites. A synthetic peptide containing the HAV-specific amino acid sequence of one of these sites induced anti-HAV-neutralizing antibodies. It is concluded that a structural homology exists between the two viruses, despite minimal primary sequence conservation.read more
Citations
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SEPIa, a knowledge-driven algorithm for predicting conformational B-cell epitopes from the amino acid sequence.
TL;DR: SEPIa is developed, a B-cell epitope predictor from the protein sequence, which is sufficiently fast to be applicable on a large scale and was applied to a test protein whose epitopes are known, human β2 adrenergic G-protein-coupled receptor, with promising results.
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Vaccinomics Approach for Designing Potential Peptide Vaccine by Targeting Shigella spp. Serine Protease Autotransporter Subfamily Protein SigA
Arafat Rahman Oany,Tahmina Pervin,Mamun Mia,Motaher Hossain,Mohammad Shahnaij,Shahin Mahmud,K. M. Kaderi Kibria +6 more
TL;DR: In vivo study of the proposed epitope might contribute to the development of functional and unique widespread vaccine, which might be an operative alleyway to thwart dysentery from the world.
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In silico models for drug discovery
TL;DR: Recognition of Nontrivial Remote Homology Relationships Involving Proteins of Helicobacter pylori: Implications for Function Recognition Nidhi Tyagi and Narayanaswamy Srinivasan and Identification of Novel Anthrax Toxin Countermeasures using In Silico Methods.
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Estimation and extraction of B-cell linear epitopes predicted by mathematical morphology approaches.
TL;DR: Two robust methods, LE prediction with/without local peak extraction (LEP‐LP and LEP‐NLP), based on antigenicity scale and mathematical morphology for the prediction of B‐cell LEs are described.
References
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Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins.
TL;DR: The algorithm is shown to be at least as good as, and usually superior to, the reported prediction methods assessed in the same way and the implication in protein folding is discussed.
Journal ArticleDOI
Prediction of protein antigenic determinants from amino acid sequences.
Thomas P. Hopp,Kenneth R. Woods +1 more
TL;DR: The method was developed using 12 proteins for which extensive immunochemical analysis has been carried out and subsequently was used to predict antigenic determinants for the following proteins, finding that the prediction success rate depended on averaging group length.
Journal ArticleDOI
Solid Phase Peptide Synthesis
TL;DR: This work has shown that effective methods of peptide synthesis are crucial to progress in this area, because only by synthesis can adequate amounts of important peptides be made available for chemical, biologi...
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