Inflammation and premature aging in advanced chronic kidney disease.
Jeroen P. Kooman,Marijke J E Dekker,Len A. Usvyat,Peter Kotanko,Frank M. van der Sande,Casper G. Schalkwijk,Paul G. Shiels,Peter Stenvinkel +7 more
TLDR
Systemic inflammation in end-stage renal disease can impair the resilience of the body to external and internal stressors by reduced functional and structural tissue reserves, and by impairing normal organ crosstalk, thus providing an explanation for the greatly increased risk of homeostatic breakdown in this population.Abstract:
Systemic inflammation in end-stage renal disease is an established risk factor for mortality and a catalyst for other complications, which are related to a premature aging phenotype, including musc...read more
Citations
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Journal ArticleDOI
Inflammation-Related Mechanisms in Chronic Kidney Disease Prediction, Progression, and Outcome.
Simona Mihai,Elena Codrici,Ionela Daniela Popescu,Ana-Maria Enciu,Lucian Albulescu,Laura Necula,Cristina Mambet,Gabriela Anton,Cristiana Tanase +8 more
TL;DR: The recent knowledge regarding the relationship between inflammation and CKD is summarized, highlighting the current proteomic approaches, as well as the inflammasomes and gut microbiota dysbiosis involvement in the setting of CKD, culminating with the troubling bidirectional connection between CKD and renal malignancy.
Journal ArticleDOI
Chronic inflammation in end-stage renal disease and dialysis.
TL;DR: Novel strategies to increase the removal of large middle molecules, such as expanded haemodialysis, may be an opportunity to decrease the inflammatory allostatic load associated with retention of middle molecular weight uraemic toxins.
Journal ArticleDOI
Higher albumin:creatinine ratio and lower estimated glomerular filtration rate are potential risk factors for decline of physical performance in the elderly: the Cardiovascular Health Study.
Petra Bůžková,Joshua I. Barzilay,Howard A Fink,John A Robbins,Jane A. Cauley,Joachim H. Ix,Kenneth J. Mukamal +6 more
TL;DR: In older adults, higher ACR and lower eGFR are potential risk factors for a decline of physical performance >2 years, and adjustment for covariates in candidate pathways did not attenuate these estimates.
Journal ArticleDOI
Inflamm-ageing: the role of inflammation in age-dependent cardiovascular disease
Luca Liberale,Luca Liberale,Fabrizio Montecucco,Jean-Claude Tardif,Peter Libby,Giovanni G. Camici +5 more
TL;DR: Recent findings in the pathophysiology of inflamm-ageing are discussed, results from clinical trials targeting its components and the potential implementation of these advances into daily clinical practice are discussed.
Journal ArticleDOI
Food as medicine: targeting the uraemic phenotype in chronic kidney disease.
Denise Mafra,Natália A. Borges,Bengt Lindholm,Paul G. Shiels,Pieter Evenepoel,Peter Stenvinkel +5 more
TL;DR: The authors discuss the mechanisms by which food and specific nutrients could affect the uraemic phenotype in chronic kidney disease (CKD), and suggest that a food-as-medicine approach could potentially be used to prevent and treat CKD and its complications.
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