Journal ArticleDOI
Inhibition of testicular luteinizing hormone receptor level by treatment with a potent luteinizing hormone-releasing hormone agonist or human chorionic gonadotropin
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TLDR
More than an elevation of endogenous LH, whether induced by single or repeated injection of a potent LHRH agonist, is capable of down regulating testicular LH receptors with a resultant long-term effect of reduced testicular size and decreased plasma testosterone concentration.About:
This article is published in Biochemical and Biophysical Research Communications.The article was published on 1977-06-06. It has received 179 citations till now. The article focuses on the topics: Human chorionic gonadotropin & Luteinizing hormone.read more
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Journal ArticleDOI
Hormonal regulation of peptide receptors and target cell responses
TL;DR: Receptor number is determined by hormone-induced changes in membrane conformation, irreversible ligand binding, and processing of ligand–receptor complexes during hormone action.
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Extrapituitary Actions of Gonadotropin-Releasing Hormone
TL;DR: Treatment with high doses of GnRH and its agonists had been predicted to be a potential means for enhancing fertility and, paradoxically, long term administration of these peptides results in sustained increases in serum gonadotropins.
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Is dehydroepiandrosterone a hormone
TL;DR: The new field of intracrinology or local formation of sex steroids from DHEA in target tissues has permitted major advances in the treatment of the two most frequent cancers, namely breast and prostate cancer, while its potential use as a physiological HRT could well provide a physiological balance of androgens and estrogens, thus offering exciting possibilities for women's health at menopause.
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Aspects of hypothalamic regulation of the pituitary gland
TL;DR: It is a privilege for me to give an account of my search for the hypothalamic regulatory hormones and, to avoid significant overlapping with Dr. Guillemin’s lecture, I will concentrate primarily on the LH-releasing hormone (LH-RH).
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New approach in the treatment of prostate cancer: Complete instead of partial withdrawal of androgens
Fernand Labrie,André Dupont,A. Bélanger,Y. Lacoursière,Jean-Pierre Raynaud,J.M. Husson,J. Gareau,Atilla T.A. Fazekas,J. Sandow,G. Monfette,J. G. Girard,Emond J,J. G. Houle +12 more
TL;DR: The present data show that complete withdrawal of androgens by combined hormonal therapy with the LHRH agonist (or castration) and a pure antiandrogen leads to a positive objective response in more than 95% of cases as opposed to 60%‐70% as reported by many groups using the previous partial hormonal therapy.
References
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Insulin-Receptor Interaction in the Obese-Hyperglycemic Mouse: A MODEL OF INSULIN RESISTANCE
TL;DR: The decrease in insulin receptors in the ob/ob mouse correlates well with the insulin resistance which they exhibit and Scatchard analysis suggests that this decrease in binding is due to a decrease in the number of receptor sites in the membrane of the obese mouse, especially those of higher affinity.
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Gonadotropin binding and stimulation of cyclic adenosine 3': 5' monophosphate and testosterone production in isolated Leydig cells
TL;DR: Gonadotropin binding and stimulation of cyclic adenosine 3':5'-monophosphate (cyclic AMP) formation and testosterone synthesis were studied in collagenase-dispersed interstitial cells from the adult rat testis Binding data were consistent with the presence of a single order of receptors, with no interaction between binding sites as mentioned in this paper.
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Regulation of receptor concentration by homologous hormone. Effect of human growth hormone on its receptor in IM-9 lymphocytes.
M A Lesniak,J Roth +1 more
TL;DR: The data indicate that in the IM-9 lymphocytes the concentration of growth hormone receptors is very sensitive to regulation by growth hormone and also add further support to the suggestion that hormones in general actively regulate the concentrations of their own receptors.
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Human Growth Hormone Radioreceptor Assay using Cultured Human Lymphocytes
TL;DR: Although sensitive and precise methods for measuring immunoreactive growth hormone in plasma are available, there have been no methods for quantitatively measuring the biological activity of growth hormone.
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Thyrotropin-releasing hormone regulates the number of its own receptors in the GH3 strain of pituitary cells in culture
TL;DR: It is concluded that in GH3 cells TRH regulates the number of its own receptors, suggesting that receptor loss is partially dependent on active protein synthesis.