Journal ArticleDOI
Inhibitory control of neostriatal projection neurons by GABAergic interneurons.
Tibor Koós,James M. Tepper +1 more
TLDR
Paired whole-cell recordings are used to show that inhibitory synaptic potentials generated from single interneurons are sufficiently powerful to delay or entirely block the generation of action potentials in a large number of projection neurons simultaneously.Abstract:
The basal ganglia are a highly interconnected network of nuclei essential for the modulation and execution of voluntary behavior The neostriatum is the principal input and one of the principal controllers of the output of the basal ganglia Neostriatal projection neurons seem to be dynamically and powerfully controlled by GABAergic inputs, but the source(s) and physiological properties of these inputs remain unclear Here we use paired whole-cell recordings to show that this inhibition derives from small populations of GABAergic interneurons that are themselves interconnected through functional electrotonic synapses Inhibitory synaptic potentials generated from single interneurons are sufficiently powerful to delay or entirely block the generation of action potentials in a large number of projection neurons simultaneouslyread more
Citations
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The molecular logic of endocannabinoid signalling
TL;DR: The endocannabinoids are a family of lipid messengers that engage the cell surface receptors that are targeted by Δ9-tetrahydrocannabinol, the active principle in marijuana (Cannabis).
Journal ArticleDOI
Role of Endogenous Cannabinoids in Synaptic Signaling
TL;DR: The synthetic pathways of endocannabinoids are discussed, along with the putative mechanisms of their release, uptake, and degradation, and the fine-grain anatomical distribution of the neuronal cannabinoid receptor CB1 is described in most brain areas, emphasizing its general presynaptic localization and role in controlling neurotransmitter release.
Journal ArticleDOI
Modulation of Striatal Projection Systems by Dopamine
TL;DR: The contrast provided by these studies has provided new insights into how the striatum responds to fluctuations in DA signaling and how diseases that alter this signaling change striatal function.
Journal ArticleDOI
Putting a spin on the dorsal–ventral divide of the striatum
Pieter Voorn,Louk J. M. J. Vanderschuren,Henk J. Groenewegen,Trevor W. Robbins,Cyriel M. A. Pennartz +4 more
TL;DR: This review presents a synthesis between the dorsal-ventral distinction and the more mediolateral-oriented functional striatal gradient.
Journal ArticleDOI
Synaptic organisation of the basal ganglia.
TL;DR: It is concluded that the essential concept of the direct and indirect pathways of information flow through the basal ganglia remains intact but that the role of the indirect pathway is more complex than previously suggested and that neurons of the globus pallidus are in a position to control the activity of virtually the whole of the basalganglia.
References
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Book reviewHandbook of Chemical Neuroanatomy: Methods in Chemical Neuroanatomy. Edited by A. Bjorklund and T. Hokfelt. Elsevier, Amsterdam, 1983. Cloth bound, 548 pp. UK £140. (Volume 1 in the series).
A Light and Electron Microscopic Study
TL;DR: A tumor mass removed from the subcutaneous tissue of the shoulder of a dog had the light and electron microscopic features of extraneuraxial meningioma, and the meningiomatous nature of the lesion was confirmed by electron microscopy.
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Synchronized oscillations in interneuron networks driven by metabotropic glutamate receptor activation
TL;DR: It is proposed that interneuron network oscillations, in conjunction with intrinsic membrane resonances and long-loop (such as thalamocortical) interactions, contribute to 40-Hz rhythms in vivo.
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Synchronization of neuronal activity in hippocampus by individual GABAergic interneurons
TL;DR: It is demonstrated that individual GABAergic interneurons can effectively phase spontaneous firing and subthreshold oscillations in hippocampal pyramidal cells at 4–7 Hz, and this GABAergic mechanism is sufficient to synchronize the firing of pyramsidal cells.