Insomnia with objective short sleep duration: the most biologically severe phenotype of the disorder.
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TLDR
Evidence is presented that insomnia with objective short sleep duration is the most biologically severe phenotype of the disorder, as it is associated with cognitive-emotional and cortical arousal, activation of both limbs of the stress system, and a higher risk for hypertension, impaired heart rate variability, diabetes, neurocognitive impairment, and mortality.About:
This article is published in Sleep Medicine Reviews.The article was published on 2013-08-01 and is currently open access. It has received 537 citations till now. The article focuses on the topics: Sleep disorder & Polysomnography.read more
Citations
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Journal ArticleDOI
Short- and Long-Term Sleep Stability in Insomniacs and Healthy Controls.
Jordan Gaines,Alexandros N. Vgontzas,Julio Fernandez-Mendoza,Maria Basta,Maria Basta,Slobodanka Pejovic,Fan He,Edward O. Bixler +7 more
TL;DR: Sleep duration variables, particularly total sleep time based on 3 consecutive nights in both patients with insomnia and controls or two single-night recordings separated by several years, are stable and reflect a person's habitual sleep.
Journal ArticleDOI
Sleep Stage Transition Dynamics Reveal Specific Stage 2 Vulnerability in Insomnia
Yishul Wei,Michele A Colombo,Michele A Colombo,Michele A Colombo,Jennifer R Ramautar,Tessa F. Blanken,Tessa F. Blanken,Ysbrand D. van der Werf,Kai Spiegelhalder,Bernd Feige,Dieter Riemann,Eus J.W. Van Someren,Eus J.W. Van Someren +12 more
TL;DR: Quantification of sleep stage dynamics revealed a particular vulnerability of stage N2 in insomnia, the feature that characterizes insomnia better than-and independently of-any conventional sleep parameter.
Journal ArticleDOI
Nocturnal cardiac autonomic profile in young primary insomniacs and good sleepers.
Massimiliano de Zambotti,Massimiliano de Zambotti,Nicola Cellini,Fiona C. Baker,Ian M. Colrain,Michela Sarlo,Luciano Stegagno +6 more
TL;DR: The findings indicated a dysfunctional sympathetic activity but a normal parasympathetic modulation before and during sleep in young adults with insomnia.
Journal ArticleDOI
Impact of the Metabolic Syndrome on Mortality is Modified by Objective Short Sleep Duration
Julio Fernandez-Mendoza,Fan He,Caitlin LaGrotte,Alexandros N. Vgontzas,Duanping Liao,Edward O. Bixler +5 more
TL;DR: The risk of mortality associated with MetS is increased in those with short sleep duration, and this effect modification was primarily driven by the elevated blood pressure and glucose dysregulation components of MetS.
Journal ArticleDOI
The effect of insomnia on development of Alzheimer's disease.
Shaghayegh Sadeghmousavi,Shaghayegh Sadeghmousavi,Mahsa Eskian,Mahsa Eskian,Farzaneh Rahmani,Farzaneh Rahmani,Farzaneh Rahmani,Nima Rezaei +7 more
TL;DR: The potential role of SD and insomnia in the pathogenesis and progression of AD is shown and this relation can help to prevent AD through screening and proper management of sleep disorders.
References
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The International Classification of Sleep Disorders: Diagnostic and Coding Manual
TL;DR: This outstanding manual is more than an outline; it includes diagnostic criteria, clinical course, predisposing factors, prevalence, differential diagnosis, and a bibliography for each of the numerous disorders.
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Impact of sleep debt on metabolic and endocrine function
TL;DR: Sleep debt has a harmful impact on carbohydrate metabolism and endocrine function similar to those seen in normal ageing and, therefore, sleep debt may increase the severity of age-related chronic disorders.
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Epidemiology of insomnia: what we know and what we still need to learn
TL;DR: The association between insomnia and major depressive episodes has been constantly reported: individuals with insomnia are more likely to have a major depressive illness and longitudinal studies have shown that the persistence of insomnia is associated with the appearance of a new depressive episode.