Journal ArticleDOI
Insulin effects in muscle and adipose tissue
TLDR
These insulin effects serve to encourage the synthesis of carbohydrate, fat and protein, therefore, insulin can be considered to be an anabolic hormone.About:
This article is published in Diabetes Research and Clinical Practice.The article was published on 2011-08-01. It has received 649 citations till now. The article focuses on the topics: White adipose tissue & Adipose tissue.read more
Citations
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Journal ArticleDOI
Association between insulin resistance and the development of cardiovascular disease
Valeska Ormazabal,Soumyalekshmi Nair,Omar Elfeky,Claudio Aguayo,Carlos Salomon,Carlos Salomon,Carlos Salomon,Felipe Zuñiga +7 more
TL;DR: It can be concluded that insulin resistance in the myocardium generates damage by at least three different mechanisms: (1) signal transduction alteration, (2) impaired regulation of substrate metabolism, and (3) altered delivery of substrates to theMyocardium.
Journal ArticleDOI
Adipose tissue in control of metabolism
Liping Luo,Meilian Liu +1 more
TL;DR: This review will summarize the recent findings of adipose tissue in the control of metabolism, focusing on its endocrine and thermogenic function.
Journal ArticleDOI
Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease.
TL;DR: The breadth and depth of metabolic flexibility and its impact on health and disease are discussed and important advances in metabolic flexibility research are outlined and medical horizons and translational aspects are outlined.
Journal ArticleDOI
Changes in Nutritional Status Impact Immune Cell Metabolism and Function.
TL;DR: Understanding how T cells are sensitive to both inadequate and overabundant nutrients may enhance the ability to target immune cell metabolism and alter immunity in both malnutrition and obesity.
Journal ArticleDOI
Obesity and dyslipidemia.
Jelena Vekic,Aleksandra Zeljkovic,Aleksandra Stefanović,Zorana Jelic-Ivanovic,Vesna Spasojevic-Kalimanovska +4 more
TL;DR: This review will address the main characteristics of dyslipidemia and mechanisms that induce its development in obesity, in particular proprotein convertase subtilisin/kexin type 9 (PCSK9), as the key molecule that regulates metabolism of low-density lipoproteins (LDL), and sphingosine-1-phosphate (S1P), as one of the most important mediators of high-densitylipoprotein (HDL) particles function.
References
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Journal ArticleDOI
Cellular mechanisms of insulin resistance
TL;DR: It is shown that commonly accepted models that attempt to explain the association of insulin resistance and obesity are incompatible with recent findings and an alternative model is proposed that appears to fit these and other available data.
Journal ArticleDOI
Mechanism of free fatty acid-induced insulin resistance in humans.
Michael Roden,Thomas B. Price,Gianluca Perseghin,Kitt Falk Petersen,Douglas L. Rothman,Gary W. Cline,Gerald I. Shulman +6 more
TL;DR: It is demonstrated that free fatty acids induce insulin resistance in humans by initial inhibition of glucose transport/phosphorylation which is then followed by an approximately 50% reduction in both the rate of muscle glycogen synthesis and glucose oxidation.
Journal ArticleDOI
Fuel selection in human skeletal muscle in insulin resistance: a reexamination.
TL;DR: Although the Randle cycle is a valid physiological principle, it may not explain insulin resistance in skeletal muscle, and recent knowledge of insulin receptor signaling indicates that the accumulation of lipid products in muscle can interfere with insulin signaling and produce insulin resistance.
Journal ArticleDOI
Regulatory interactions between lipids and carbohydrates: the glucose fatty acid cycle after 35 years
TL;DR: Evidence for inhibitory effects of fatty acids on whole body glucose utilization ad oxidation (predominantly muscles) is decisive and enzyme mechanisms mediating these effects are well established, and a permissive role for fatty acids in the insulin secretory response of islet beta-cells has now been firmly established.
Book
Biochemistry for the Medical Sciences
Eric A. Newsholme,A. R. Leech +1 more
TL;DR: This outstanding text, written in a clear, concise and easy-to-read style, provides students with an in-depth explanation of how each metabolic pathway is directly related to physiology, pharmacology, and clinical medicine.
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