Journal ArticleDOI
Insulin-like growth factors: a role in growth hormone negative feedback and body weight regulation via brain.
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TLDR
Findings suggest that insulin-like growth factors play a role in growth hormone negative feedback and body weight regulation at the level of the central nervous system.Abstract:
Intracerebroventricular administration of ILA's, a preparation enriched in insulin-like growth factors, caused a marked decrease in growth hormone secretory episodes and in body weight associated with reduced food intake over 24 hours. Central injection of insulin and bovine serum albumin had no such effects. These findings suggest that insulin-like growth factors play a role in growth hormone negative feedback and body weight regulation at the level of the central nervous system.read more
Citations
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Journal ArticleDOI
Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms
Eugenia E. Calle,Rudolf Kaaks +1 more
TL;DR: Gaining a better understanding of the relationship between obesity and cancer can provide new insight into mechanisms of cancer pathogenesis.
Journal ArticleDOI
Pathophysiology of the neuroregulation of growth hormone secretion in experimental animals and the human
TL;DR: The pathophysiology of the GHRH somatostatin-GH-IGF-I feedback axis is reviewed and it is proposed that this system is best viewed as a multivalent feedback network that is exquisitely sensitive to an array of neuroregulators and environmental stressors and genetic restraints.
Journal ArticleDOI
Roles of growth hormone and insulin-like growth factor 1 in mouse postnatal growth.
TL;DR: This genetic study has provided conclusive evidence demonstrating that GH and IGF1 promote postnatal growth by both independent and common functions, as the growth retardation of double Ghr/Igf1 nullizygotes is more severe than that observed with either class of single mutant.
Journal ArticleDOI
Sexual dimorphism in the control of growth hormone secretion.
TL;DR: A feminization of the liver develops after continuous, but not intermittent, administration of GH to hypophysectomized rats, suggesting that high, infrequent GH pulses with low plasma GH levels in between promotes growth more effectively than an intermediate, rather constant level of plasma GH.
Journal ArticleDOI
Serum C-Peptide, Insulin-Like Growth Factor (IGF)-I, IGF-Binding Proteins, and Colorectal Cancer Risk in Women
Rudolf Kaaks,Paolo Toniolo,Arslan Akhmedkhanov,Annekatrin Lukanova,Carine Biessy,Henri Déchaud,Sabina Rinaldi,Anne Zeleniuch-Jacquotte,Roy E. Shore,Elio Riboli +9 more
TL;DR: Ch Chronically high levels of circulating insulin and IGFs associated with a Western lifestyle may increase colorectal cancer risk, possibly by decreasing IGFBP-1 and increasing the bioactivity of IGF-I.
References
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Book
Textbook of endocrinology
TL;DR: To squeeze all of this into a man¬ ageable volume, the publisher has gone to a smaller type size than before, smaller than usual in medical texts, but the end result is a uniform, informative style.
Journal ArticleDOI
Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons
Stephen C. Woods,Stephen C. Woods,Elizabeth C. Lotter,Elizabeth C. Lotter,L. David McKay,L. David McKay,Daniel Porte,Daniel Porte +7 more
TL;DR: Additional evidence is presented by showing that in baboons the infusion of exogenous insulin into the CSF elicits a reliable and predictable decrease in food intake and body weight.
Journal ArticleDOI
Behavioral Regulation of the Milieu Interne in Man and Rat
TL;DR: This specialized conditioning mechanism, which specifically adjusts gustatory hedonic values through delayed visceral feedback, is widespread among animals, including man and rat, and is based on the animals' having similar gustatory systems, similar convergence of gustatory and internal afferents to the nucleus solitarius, and similar midbrain regulatory mechanisms.
Journal ArticleDOI
Somatomedin: Proposed Designation for Sulphation Factor
TL;DR: The observations underlying this hypothesis have been amply confirmed and extended and a GH-dependent plasma factor stimulates in cartilage not only the incorporation of sulphate into chondroitin sulphate, but also the incorporate of thymidine into DNA and proline into the hydroxyproline of collagen.
Journal ArticleDOI
Somatomedin-C mediates growth hormone negative feedback by effects on both the hypothalamus and the pituitary
Michael Berelowitz,Marta Szabo,Lawrence A. Frohman,Susan Firestone,Lily Chu,Raymond L. Hintz +5 more
TL;DR: It is suggested that somatomedin-C participates in the growth hormone negative feedback loop with an immediate effect on hypothalamic somatostatin and a delayed effect on the anterior pituitary.
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