Intellectual asymmetry and genetic liability in first-degree relatives of probands with schizophrenia
Eugenia Kravariti,Timothea Toulopoulou,F. Mapua-Filbey,Katja Schulze,Muriel Walshe,Pak C. Sham,Robin M. Murray,Colm McDonald +7 more
Reads0
Chats0
TLDR
Investigating the association of a continuous measure of genetic liability to schizophrenia with Verbal-Spatial Contrast IQ in 108 first-degree relatives without psychosis of probands with schizophrenia found higher genetic liability was significantly associated with greater intellectual asymmetry in favour of verbal skills.Abstract:
Intellectual asymmetry with superiority of verbal skills to spatial skills frequently characterises patients with schizophrenia, but it is unclear whether this pattern also reflects genetic susceptibility to the disorder. We examined the association of a continuous measure of genetic liability to schizophrenia with Verbal-Spatial Contrast IQ (an index of intellectual asymmetry) in 108 first-degree relatives without psychosis of probands with schizophrenia. Higher genetic liability was significantly associated with greater intellectual asymmetry in favour of verbal skills. Intellectual asymmetry with a relative superiority of verbal skills to spatial skills represents a putative endophenotype of schizophrenia.read more
Citations
More filters
Journal ArticleDOI
Psychosis and autism as diametrical disorders of the social brain
TL;DR: Evidence regarding the genetic, physiological, neurological, and psychological underpinnings of psychotic-spectrum conditions supports the hypothesis that the etiologies of these conditions involve biases towards increased relative effects from imprinted genes with maternal expression, which engender a general pattern of undergrowth.
Journal ArticleDOI
A conceptual framework for the neurobiological study of resilience
TL;DR: This work proposes a unified theoretical framework for the neuroscientific study of general resilience mechanisms and posits that a positive (non-negative) appraisal style is the key mechanism that protects against the detrimental effects of stress and mediates the effects of other known resilience factors.
Journal ArticleDOI
Evidence of Common Genetic Overlap Between Schizophrenia and Cognition
Leon Hubbard,Katherine E. Tansey,Dheeraj Rai,Peter B. Jones,Stephan Ripke,Kimberly Chambert,Jennifer L. Moran,Steven A. McCarroll,David Edmund Johannes Linden,Michael John Owen,Michael Conlon O'Donovan,James T.R. Walters,Stanley Zammit +12 more
TL;DR: A genetic relationship between schizophrenia and performance IQ is observed but not verbal IQ or other cognitive variables, which may have implications for studies utilizing cognitive endophenotypes for psychosis.
Journal ArticleDOI
Autism As a Disorder of High Intelligence
TL;DR: Findings indicate that alleles for autism overlap broadly with allele for high intelligence, which appears paradoxical given that autism is characterized, overall, by below-average IQ.
Journal ArticleDOI
The effects of trauma types, cumulative trauma, and PTSD on IQ in two highly traumatized adolescent groups
TL;DR: This paper investigated the relationship between trauma type, posttraumatic stress disorder (PTSD), and intelligence quotient (IQ) utilizing a development-based taxonomy of trauma in a sample of 390 African-American adolescents and Iraqi refugee adolescents.
References
More filters
Journal ArticleDOI
The Endophenotype Concept in Psychiatry: Etymology and Strategic Intentions
TL;DR: The authors discuss the etymology and strategy behind the use of endophenotypes in neuropsychiatric research and, more generally, in research on other diseases with complex genetics.
Journal ArticleDOI
Neurocognitive Deficit in Schizophrenia: A Quantitative Review of the Evidence
TL;DR: The results indicate that schizophrenia is characterized by a broadly based cognitive impairment, with varying degrees of deficit in all ability domains measured by standard clinical tests.
Journal ArticleDOI
A classification of hand preference by association analysis.
TL;DR: An association analysis was made of the responses of young adults to a hand-preference questionnaire and it is believed to demonstrate that hand preference is distributed continuously and not discretely.
Journal ArticleDOI
Diagnostic Interview for Genetic Studies: Rationale, Unique Features, and Training
John I. Nurnberger,Mary C. Blehar,Charles A. Kaufmann,Carolyn York-Cooler,Sylvia G. Simpson,Jill M. Harkavy-Friedman,Joanne B. Severe,Dolores Malaspina,Theodore Reich +8 more
TL;DR: The DIGS is designed to be employed by interviewers who exercise significant clinical judgment and who summarize information in narrative form as well as in ratings, and should be useful as part of archival data gathering for genetic studies of major affective disorders, schizophrenia, and related conditions.
Related Papers (5)
Psychosis and autism as diametrical disorders of the social brain
Sex differences in mental abilities: g masks the dimensions on which they lie
Wendy Johnson,Thomas J. Bouchard +1 more
‘Salience syndrome’ replaces ‘schizophrenia’ in DSM‐V and ICD‐11: psychiatry’s evidence‐based entry into the 21st century?
Evidence that duplications of 22q11.2 protect against schizophrenia
Elliott Rees,George Kirov,Alan R. Sanders,James T.R. Walters,Kimberly Chambert,Jing Shi,Jin P. Szatkiewicz,Colm O'Dushlaine,Alexander Richards,Elaine K. Green,Elaine K. Green,Ian Jones,Geraint Davies,Sophie E. Legge,Jennifer L. Moran,Carlos N. Pato,M. T. Pato,Giulio Genovese,Douglas F. Levinson,Jubao Duan,Winton Moy,Harald H H Göring,Derek W. Morris,Paul Cormican,Kenneth S. Kendler,Francis A. O'Neill,Brien P. Riley,Michael Gill,Aiden Corvin,Nicholas John Craddock,Pamela Sklar,Christina M. Hultman,Patrick F. Sullivan,Patrick F. Sullivan,Pablo V. Gejman,Steven A. McCarroll,Michael Conlon O'Donovan,Michael John Owen +37 more