Journal ArticleDOI
Intelligent Hollow Pt-CuS Janus Architecture for Synergistic Catalysis-Enhanced Sonodynamic and Photothermal Cancer Therapy.
Shuang Liang,Xiaoran Deng,Yun Chang,Chunqiang Sun,Shuai Shao,Zhongxi Xie,Zhongxi Xie,Xiao Xiao,Xiao Xiao,Ping'an Ma,Haiyuan Zhang,Haiyuan Zhang,Ziyong Cheng,Ziyong Cheng,Jun Lin,Jun Lin +15 more
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TLDR
A novel Pt-CuS Janus composed of hollow semiconductor CuS and noble metallic Pt was rationally designed and successfully synthesized and develops a versatile nanoplatform for a multifunctional theranostic strategy and broadens the biological applications by rationally designing their structure.Abstract:
As a noninvasive treatment modality, ultrasound (US)-triggered sonodynamic therapy (SDT) shows broad and promising applications to overcome the drawbacks of traditional photodynamic therapy (PDT) in combating cancer. However, the SDT efficacy is still not satisfactory without oxygen (O2) assistance. In addition, there is also much space to explore the SDT-based synergistic therapeutic modalities. Herein, a novel Pt-CuS Janus composed of hollow semiconductor CuS and noble metallic Pt was rationally designed and successfully synthesized. The hollow CuS shows a large inner cavity for loading sonosensitizer molecules (tetra-(4-aminophenyl) porphyrin, TAPP) to implement SDT. Moreover, the deposition of Pt not only enhances photothermal performance compared with those of CuS nanoparticles (NPs) due to the effect of the local electric field enhancement but also possesses nanozyme activity for catalyzing decomposition of endogenous overexpressed hydrogen peroxide (H2O2) to produce O2 that can overcome tumor hypoxia and augment the SDT-induced highly toxic reactive oxygen species (ROS) production for efficient cancer cell apoptosis. Importantly, the generated heat of Pt-CuS by 808 nm laser irradiation can accelerate the catalytic activity of Pt and elevate the O2 level that further facilitates SDT efficacy. Interestingly, the thermally sensitive copolymer coated around the Janus can act as a smart switch to regulate the catalytic ability of Pt and control TAPP release that has a significant effect on modulating the therapeutic effect. The synergistic catalysis-enhanced SDT efficiency and highly photothermal effect almost realized complete tumor resection without obvious reoccurrence and simultaneously displayed a highly therapeutic biosafety. Furthermore, the high optical absorbance allows the as-synthesized Pt-CuS Janus for photoacoustic (PA) imaging and NIR thermal imaging. This work develops a versatile nanoplatform for a multifunctional theranostic strategy and broadens the biological applications by rationally designing their structure.read more
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Journal ArticleDOI
Multifunctional sonosensitizers in sonodynamic cancer therapy
Subin Son,Ji Hyeon Kim,Xianwen Wang,Chuangli Zhang,Shin A Yoon,Jinwoo Shin,Amit Sharma,Min Hee Lee,Liang Cheng,Jiasheng Wu,Jong Seung Kim +10 more
TL;DR: This review article highlights the recent advances in SDT in terms of sonosensitizers and their formulations and anticancer therapeutic efficacy and the potential ofSDT in combination with other modalities to address unmet needs in precision medicine.
Journal ArticleDOI
Second near-infrared photothermal materials for combinational nanotheranostics
TL;DR: This review summarizes the recent advances of NIR-II photothermal combinational theranostics pertinent to chemotherapy, immunotherapy, radiotherapy, and photodynamic, sonodynamic, chemodynamic, gene, gas, ionic, vascular and magnetothermal therapy.
Journal ArticleDOI
Ultrafine Titanium Monoxide (TiO1+x) Nanorods for Enhanced Sonodynamic Therapy
Xianwen Wang,Xiaoyan Zhong,Lixin Bai,Jun Xu,Fei Gong,Ziliang Dong,Zhijuan Yang,Zhijie Zeng,Zhuang Liu,Liang Cheng +9 more
TL;DR: This work highlights a new type of titanium-based nanostructure with great performance for tumor SDT, PEG-TiO1+x NRs, which can be used as a sono-sensitizer and CDT agent for highly effective tumor ablation under US treatment.
Journal ArticleDOI
Recent Advances in Nanomaterial-Assisted Combinational Sonodynamic Cancer Therapy.
Shuang Liang,Shuang Liang,Xiaoran Deng,Ping'an Ma,Ping'an Ma,Ziyong Cheng,Ziyong Cheng,Jun Lin,Jun Lin +8 more
TL;DR: The design principles in achieving synergistic therapeutic effects based on nanomaterial engineering methods are highlighted and the ultimate goals are to stimulate the design of better‐quality combined sonodynamic treatment schemes and provide innovative ideas for the perspectives of SDT in promoting its future transformation to clinical application.
Journal ArticleDOI
Ultrasound-Switchable Nanozyme Augments Sonodynamic Therapy against Multidrug-Resistant Bacterial Infection.
Duo Sun,Xin Pang,Yi Cheng,Jiang Ming,Sijin Xiang,Chang Zhang,Peng Lv,Chengchao Chu,Xiaolan Chen,Gang Liu,Nanfeng Zheng +10 more
TL;DR: The developed ultrasound-switchable nanoenzyme system provides a promising strategy for augmenting sonodynamic eradiation of deep-seated bacterial infection actively, controllably and precisely.
References
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Journal ArticleDOI
Local field enhanced Au/CuS nanocomposites as efficient photothermal transducer agents for cancer treatment.
TL;DR: It is demonstrated for the first time that surface plasmon coupling can be used to enhance CuS nanoparticle PTT for cancer treatment.
Journal ArticleDOI
O2-Loaded pH-Responsive Multifunctional Nanodrug Carrier for Overcoming Hypoxia and Highly Efficient Chemo-Photodynamic Cancer Therapy
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TL;DR: A novel multifunctional nanodrug carrier UC@mSiO2-RB@ZIF-O2,DOX-PEGFA (URODF) that combines oxygen-enhanced photodynamic therapy (PDT) with pH-responsive chemotherapy is presented.
Journal ArticleDOI
Room-Temperature Synthesis of Covellite Nanoplatelets with Broadly Tunable Localized Surface Plasmon Resonance
Maixian Liu,Xiaozheng Xue,Chayanjit Ghosh,Xin Liu,Yang Liu,Edward P. Furlani,Mark T. Swihart,Paras N. Prasad +7 more
TL;DR: In this paper, the first report of ambient-temperature preparation of covellite nanoplatelets is presented, where the lateral dimensions of these are controllable over a wide range while maintaining a constant thickness of 4 nm.
Journal ArticleDOI
Tailored Surfaces on 2D Material: UFO‐Like Cyclodextrin‐Pd Nanosheet/Metal Organic Framework Janus Nanoparticles for Synergistic Cancer Therapy
TL;DR: The in vitro and in vivo results show that the dual‐drug loaded JNPs under a laser‐irradiation group present highest cancer therapeutic efficiency and significantly broadens the application prospects of metal–metal organic framework JNBP by rationally designing their compositions and discovering related physiochemical properties.
Journal ArticleDOI
Versatile routes toward functional, water-soluble nanoparticles via trifluoroethylester-PEG-thiol ligands.
TL;DR: A trifluoroethylester-PEG-thiol ligand is synthesized and its use to create water-soluble, chemically functional Au metal and FePt magnetic nanoparticles are reported.