Journal ArticleDOI
Intelligent Hollow Pt-CuS Janus Architecture for Synergistic Catalysis-Enhanced Sonodynamic and Photothermal Cancer Therapy.
Shuang Liang,Xiaoran Deng,Yun Chang,Chunqiang Sun,Shuai Shao,Zhongxi Xie,Zhongxi Xie,Xiao Xiao,Xiao Xiao,Ping'an Ma,Haiyuan Zhang,Haiyuan Zhang,Ziyong Cheng,Ziyong Cheng,Jun Lin,Jun Lin +15 more
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TLDR
A novel Pt-CuS Janus composed of hollow semiconductor CuS and noble metallic Pt was rationally designed and successfully synthesized and develops a versatile nanoplatform for a multifunctional theranostic strategy and broadens the biological applications by rationally designing their structure.Abstract:
As a noninvasive treatment modality, ultrasound (US)-triggered sonodynamic therapy (SDT) shows broad and promising applications to overcome the drawbacks of traditional photodynamic therapy (PDT) in combating cancer. However, the SDT efficacy is still not satisfactory without oxygen (O2) assistance. In addition, there is also much space to explore the SDT-based synergistic therapeutic modalities. Herein, a novel Pt-CuS Janus composed of hollow semiconductor CuS and noble metallic Pt was rationally designed and successfully synthesized. The hollow CuS shows a large inner cavity for loading sonosensitizer molecules (tetra-(4-aminophenyl) porphyrin, TAPP) to implement SDT. Moreover, the deposition of Pt not only enhances photothermal performance compared with those of CuS nanoparticles (NPs) due to the effect of the local electric field enhancement but also possesses nanozyme activity for catalyzing decomposition of endogenous overexpressed hydrogen peroxide (H2O2) to produce O2 that can overcome tumor hypoxia and augment the SDT-induced highly toxic reactive oxygen species (ROS) production for efficient cancer cell apoptosis. Importantly, the generated heat of Pt-CuS by 808 nm laser irradiation can accelerate the catalytic activity of Pt and elevate the O2 level that further facilitates SDT efficacy. Interestingly, the thermally sensitive copolymer coated around the Janus can act as a smart switch to regulate the catalytic ability of Pt and control TAPP release that has a significant effect on modulating the therapeutic effect. The synergistic catalysis-enhanced SDT efficiency and highly photothermal effect almost realized complete tumor resection without obvious reoccurrence and simultaneously displayed a highly therapeutic biosafety. Furthermore, the high optical absorbance allows the as-synthesized Pt-CuS Janus for photoacoustic (PA) imaging and NIR thermal imaging. This work develops a versatile nanoplatform for a multifunctional theranostic strategy and broadens the biological applications by rationally designing their structure.read more
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Boron Imidazolate Framework‐Derived Porous Carbon Nanospheres for Dual‐Mode Bioimaging‐Guided Photothermal/Sonodynamic Synergistic Cancer Therapy
Lin Ze Du,Shuangsong Ren,Ye Qi,Ru Wen,Yue Feng,Mengying Tong,Xiaohui Liu,Yachen Li,Ying Chen +8 more
TL;DR: The PCNS not only exhibits satisfactory and excellent photothermal conversion ability under near‐infrared laser irradiation but also demonstrates a promising capability as an efficient sonosensitizer to generate cytotoxic reactive oxygen species through inertial cavitation in response to low‐intensity ultrasound stimulation.
Journal ArticleDOI
Multifaceted Nanozymes for Synergistic Antitumor Therapy: A Review
TL;DR: In this article , the authors summarize the recent advances in multifunctional nanozymes with an emphasis on their applications in catalytic therapy combined with immunotherapy, phototherapy, sonodynamic therapy, radiotherapy, and chemotherapy.
Journal ArticleDOI
Palladium cubes with Pt shell deposition for localized surface plasmon resonance enhanced photodynamic and photothermal therapy of hypoxic tumors.
Wenxiang Gu,Fenglei Gao,Zhiyuan Hua,Dušan Pavlović,Zheng Li,Zhiheng Cai,Wandong Wang,Kaijin Guo,Feng Yuan,Fenglei Gao,Hongliang Chen +10 more
TL;DR: In this article, Pd nanocubes coated with an ultrathin Pt shell were prepared and further conjugated with fluorescein labeled and thiol functionalized polyethylene glycol (FITC-PEG-SH) to enhance the photothermal performance, exhibiting excellent hyperthermia outcomes and impressive photothermal imaging quality.
Journal ArticleDOI
Palladium cubes with Pt shell deposition for localized surface plasmon resonance enhanced photodynamic and photothermal therapy of hypoxic tumors
Fenglei Gao,Dušan Pavlović +1 more
TL;DR: In this paper , Pd nanocubes coated with an ultrathin Pt shell were prepared and further conjugated with fluorescein labeled and thiol functionalized polyethylene glycol (FITC-PEG-SH) to enhance the photothermal performance, exhibiting excellent hyperthermia outcomes and impressive photothermal imaging quality.
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