Journal ArticleDOI
Intelligent Hollow Pt-CuS Janus Architecture for Synergistic Catalysis-Enhanced Sonodynamic and Photothermal Cancer Therapy.
Shuang Liang,Xiaoran Deng,Yun Chang,Chunqiang Sun,Shuai Shao,Zhongxi Xie,Zhongxi Xie,Xiao Xiao,Xiao Xiao,Ping'an Ma,Haiyuan Zhang,Haiyuan Zhang,Ziyong Cheng,Ziyong Cheng,Jun Lin,Jun Lin +15 more
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TLDR
A novel Pt-CuS Janus composed of hollow semiconductor CuS and noble metallic Pt was rationally designed and successfully synthesized and develops a versatile nanoplatform for a multifunctional theranostic strategy and broadens the biological applications by rationally designing their structure.Abstract:
As a noninvasive treatment modality, ultrasound (US)-triggered sonodynamic therapy (SDT) shows broad and promising applications to overcome the drawbacks of traditional photodynamic therapy (PDT) in combating cancer. However, the SDT efficacy is still not satisfactory without oxygen (O2) assistance. In addition, there is also much space to explore the SDT-based synergistic therapeutic modalities. Herein, a novel Pt-CuS Janus composed of hollow semiconductor CuS and noble metallic Pt was rationally designed and successfully synthesized. The hollow CuS shows a large inner cavity for loading sonosensitizer molecules (tetra-(4-aminophenyl) porphyrin, TAPP) to implement SDT. Moreover, the deposition of Pt not only enhances photothermal performance compared with those of CuS nanoparticles (NPs) due to the effect of the local electric field enhancement but also possesses nanozyme activity for catalyzing decomposition of endogenous overexpressed hydrogen peroxide (H2O2) to produce O2 that can overcome tumor hypoxia and augment the SDT-induced highly toxic reactive oxygen species (ROS) production for efficient cancer cell apoptosis. Importantly, the generated heat of Pt-CuS by 808 nm laser irradiation can accelerate the catalytic activity of Pt and elevate the O2 level that further facilitates SDT efficacy. Interestingly, the thermally sensitive copolymer coated around the Janus can act as a smart switch to regulate the catalytic ability of Pt and control TAPP release that has a significant effect on modulating the therapeutic effect. The synergistic catalysis-enhanced SDT efficiency and highly photothermal effect almost realized complete tumor resection without obvious reoccurrence and simultaneously displayed a highly therapeutic biosafety. Furthermore, the high optical absorbance allows the as-synthesized Pt-CuS Janus for photoacoustic (PA) imaging and NIR thermal imaging. This work develops a versatile nanoplatform for a multifunctional theranostic strategy and broadens the biological applications by rationally designing their structure.read more
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Molecular Imaging-Guided Sonodynamic Therapy.
TL;DR: In this article, the authors focus on the molecular imaging-guided low-intensity ultrasound-triggered sonodynamic therapy (SDT) for the treatment of cancer, bacterial infections, and vascular diseases.
Journal ArticleDOI
Temperature Feedback-Controlled Photothermal/Photodynamic/Chemodynamic Combination Cancer Therapy Based on NaGdF4:Er,Yb@NaGdF4:Nd@Cu-BIF Nanoassemblies
Ye Qi,Junwei Ye,Shuangsong Ren,Guangyao Wang,Jialin Lv,Siqi Zhang,Ying Che,Yachen Li,Baojiu Chen,Guiling Ning +9 more
TL;DR: The significant difference between the eigen temperature of CSNPs@Cu‐BIF nanoassemblies obtained by the temperature‐sensitive emission bands signal changes and the apparent temperature recorded by the thermal imaging camera is 14.55 K at equilibrium, which supplies an alternative strategy in temperature feedback‐controlled accurate cancer therapy.
Journal ArticleDOI
Metallic Nanoparticle-Mediated Immune Cell Regulation and Advanced Cancer Immunotherapy.
TL;DR: In this article, the role of nanoparticles in tumor microenvironment modulation and anticancer therapy was discussed, and the response of MNP-mediated immune cells, such as dendritic cells, macrophages, T cells and NK cells, against tumor cells was evaluated.
Journal ArticleDOI
Current status and prospects of MOFs in controlled delivery of Pt anticancer drugs.
Jinyi Chen,Zhixin Zhang,Jiaxin Ma,Alireza Nezamzadeh-Ejhieh,Chengyu Lu,Ying Pan,Jian-Qiang Liu +6 more
TL;DR: In this article , the application of platinum as an anticancer drug and the composite anticancer properties of platinum and MOF materials and prospects for its future development are reviewed, which provides a new direction for further research in the biomedical field.
Journal ArticleDOI
From biology to biology: Hematoporphyrin-melanin nanoconjugates with synergistic sonodynamic-photothermal effects on malignant tumors
Jiulong Zhang,Chunzi Shi,Fei Shan,Nannan Shi,Wen Ye,Yaoyao Zhuo,Yijun Zhang,Zhiyong Zhang,Yuxin Shi,Chen Peng,Chen Peng +10 more
TL;DR: The hematoporphyrin-melanin nanoconjugates modified from biology can be served as multifunctional nanoagents for tumor theranostic, and it would inspire to develop novel agents modified frombiology and then utilize them for biology.
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