Journal ArticleDOI
Intelligent Hollow Pt-CuS Janus Architecture for Synergistic Catalysis-Enhanced Sonodynamic and Photothermal Cancer Therapy.
Shuang Liang,Xiaoran Deng,Yun Chang,Chunqiang Sun,Shuai Shao,Zhongxi Xie,Zhongxi Xie,Xiao Xiao,Xiao Xiao,Ping'an Ma,Haiyuan Zhang,Haiyuan Zhang,Ziyong Cheng,Ziyong Cheng,Jun Lin,Jun Lin +15 more
Reads0
Chats0
TLDR
A novel Pt-CuS Janus composed of hollow semiconductor CuS and noble metallic Pt was rationally designed and successfully synthesized and develops a versatile nanoplatform for a multifunctional theranostic strategy and broadens the biological applications by rationally designing their structure.Abstract:
As a noninvasive treatment modality, ultrasound (US)-triggered sonodynamic therapy (SDT) shows broad and promising applications to overcome the drawbacks of traditional photodynamic therapy (PDT) in combating cancer. However, the SDT efficacy is still not satisfactory without oxygen (O2) assistance. In addition, there is also much space to explore the SDT-based synergistic therapeutic modalities. Herein, a novel Pt-CuS Janus composed of hollow semiconductor CuS and noble metallic Pt was rationally designed and successfully synthesized. The hollow CuS shows a large inner cavity for loading sonosensitizer molecules (tetra-(4-aminophenyl) porphyrin, TAPP) to implement SDT. Moreover, the deposition of Pt not only enhances photothermal performance compared with those of CuS nanoparticles (NPs) due to the effect of the local electric field enhancement but also possesses nanozyme activity for catalyzing decomposition of endogenous overexpressed hydrogen peroxide (H2O2) to produce O2 that can overcome tumor hypoxia and augment the SDT-induced highly toxic reactive oxygen species (ROS) production for efficient cancer cell apoptosis. Importantly, the generated heat of Pt-CuS by 808 nm laser irradiation can accelerate the catalytic activity of Pt and elevate the O2 level that further facilitates SDT efficacy. Interestingly, the thermally sensitive copolymer coated around the Janus can act as a smart switch to regulate the catalytic ability of Pt and control TAPP release that has a significant effect on modulating the therapeutic effect. The synergistic catalysis-enhanced SDT efficiency and highly photothermal effect almost realized complete tumor resection without obvious reoccurrence and simultaneously displayed a highly therapeutic biosafety. Furthermore, the high optical absorbance allows the as-synthesized Pt-CuS Janus for photoacoustic (PA) imaging and NIR thermal imaging. This work develops a versatile nanoplatform for a multifunctional theranostic strategy and broadens the biological applications by rationally designing their structure.read more
Citations
More filters
Journal ArticleDOI
Multifunctional sonosensitizers in sonodynamic cancer therapy
Subin Son,Ji Hyeon Kim,Xianwen Wang,Chuangli Zhang,Shin A Yoon,Jinwoo Shin,Amit Sharma,Min Hee Lee,Liang Cheng,Jiasheng Wu,Jong Seung Kim +10 more
TL;DR: This review article highlights the recent advances in SDT in terms of sonosensitizers and their formulations and anticancer therapeutic efficacy and the potential ofSDT in combination with other modalities to address unmet needs in precision medicine.
Journal ArticleDOI
Second near-infrared photothermal materials for combinational nanotheranostics
TL;DR: This review summarizes the recent advances of NIR-II photothermal combinational theranostics pertinent to chemotherapy, immunotherapy, radiotherapy, and photodynamic, sonodynamic, chemodynamic, gene, gas, ionic, vascular and magnetothermal therapy.
Journal ArticleDOI
Ultrafine Titanium Monoxide (TiO1+x) Nanorods for Enhanced Sonodynamic Therapy
Xianwen Wang,Xiaoyan Zhong,Lixin Bai,Jun Xu,Fei Gong,Ziliang Dong,Zhijuan Yang,Zhijie Zeng,Zhuang Liu,Liang Cheng +9 more
TL;DR: This work highlights a new type of titanium-based nanostructure with great performance for tumor SDT, PEG-TiO1+x NRs, which can be used as a sono-sensitizer and CDT agent for highly effective tumor ablation under US treatment.
Journal ArticleDOI
Recent Advances in Nanomaterial-Assisted Combinational Sonodynamic Cancer Therapy.
Shuang Liang,Shuang Liang,Xiaoran Deng,Ping'an Ma,Ping'an Ma,Ziyong Cheng,Ziyong Cheng,Jun Lin,Jun Lin +8 more
TL;DR: The design principles in achieving synergistic therapeutic effects based on nanomaterial engineering methods are highlighted and the ultimate goals are to stimulate the design of better‐quality combined sonodynamic treatment schemes and provide innovative ideas for the perspectives of SDT in promoting its future transformation to clinical application.
Journal ArticleDOI
Ultrasound-Switchable Nanozyme Augments Sonodynamic Therapy against Multidrug-Resistant Bacterial Infection.
Duo Sun,Xin Pang,Yi Cheng,Jiang Ming,Sijin Xiang,Chang Zhang,Peng Lv,Chengchao Chu,Xiaolan Chen,Gang Liu,Nanfeng Zheng +10 more
TL;DR: The developed ultrasound-switchable nanoenzyme system provides a promising strategy for augmenting sonodynamic eradiation of deep-seated bacterial infection actively, controllably and precisely.
References
More filters
Journal ArticleDOI
Breaking the Depth Dependency of Phototherapy with Cerenkov Radiation and Low Radiance Responsive Nanophotosensitizers
TL;DR: It is shown that administration of transferrin-coated TiO2 nanoparticles and clinical grade radionuclides in mice and co-localization in tumours resulted in either complete tumour remission or increased their median survival.
Journal ArticleDOI
Oxygen-Deficient Black Titania for Synergistic/Enhanced Sonodynamic and Photoinduced Cancer Therapy at Near Infrared-II Biowindow.
TL;DR: This work provides the paradigm of high therapeutic efficacy of a combined sono-/photoinduced tumor-treatment protocol and significantly broadens the nanomedical applications of semiconductor-based nanoplatforms by rational design of their nanostructures and control of their physiochemical properties.
Journal ArticleDOI
A Comparative Study of Hollow Copper Sulfide Nanoparticles and Hollow Gold Nanospheres on Degradability and Toxicity
Laingran Guo,Irene Panderi,Daisy D. Yan,Kevin Szulak,Yajuan Li,Yi-Tzai Chen,Hang Ma,Daniel B. Niesen,Navindra P. Seeram,Aftab Ahmed,Bingfang Yan,Dionysios Pantazatos,Wei Lu,Wei Lu +13 more
TL;DR: Comparison of hollow CuS nanoparticles with hollow gold nanospheres in similar particle sizes and morphology following intravenous administration to mice will advance the development of HCuSNPs as a new class of biodegradable inorganic nanomaterials for photothermal therapy.
Journal ArticleDOI
A Hollow-Structured CuS@Cu2S@Au Nanohybrid: Synergistically Enhanced Photothermal Efficiency and Photoswitchable Targeting Effect for Cancer Theranostics
Xiaoran Deng,Kai Li,Xuechao Cai,Bin Liu,Yi Wei,Kerong Deng,Zhongxi Xie,Zhijian Wu,Ping'an Ma,Zhiyao Hou,Ziyong Cheng,Jun Lin +11 more
TL;DR: Hollow‐structured CuS@Cu2S@Au nanoshell/satellite nanoparticles are designed and synthesized for enhanced photothermal therapy and photoswitchable targeting theranostics and stimuli‐responsive targeted cancer therapy.
Journal ArticleDOI
Treating cancer with sonodynamic therapy: A review
David Costley,Conor Mc Ewan,Colin Fowley,Anthony P. McHale,Jordan Atchison,Nikolitsa Nomikou,John F. Callan +6 more
TL;DR: This article critically review the current literature on SDT and discusses strategies that have been developed in combination with SDT to enhance the therapeutic outcome.