Journal ArticleDOI
Interaction of isoflurane with the dopamine transporter.
John R. Votaw,Michael G. Byas-Smith,Jian Hua,Ronald J. Voll,Laurent Martarello,Allan I. Levey,F. DuBois Bowman,Mark M. Goodman +7 more
TLDR
In vitro experiments indicate that DAT is trafficked into the cell by isoflurane without changing the total amount of DAT in the striatum, and the PET data are consistent with this finding, provided that intracellular DAT acquires a conformation that has low affinity for [18F]FECNT.Abstract:
BackgroundIsoflurane administration is known to increase extracellular dopamine (DA) concentration Because the dopamine transporter (DAT) is a key regulator of DA, it is likely affected by isoflurane This study investigates the hypothesis that isoflurane inhibits DA reuptake by causing DAT to be tread more
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Small animal imaging with high resolution single photon emission tomography.
Paul D. Acton,Hank F. Kung +1 more
TL;DR: This review of the most recent developments in SPECT imaging of small animals is summarized, with particular reference to the types of systems available, their application, and some of the potential limitations.
Journal ArticleDOI
Anaesthesia for positron emission tomography scanning of animal brains.
TL;DR: Findings of PET studies carried out either in both awake and anaesthetized animals or in animals given at least two different anaesthetics are reviewed, providing a means of estimating the extent to which anaesthesia affects the outcome of PET neuroimaging in animals.
Journal ArticleDOI
Serotonin 2A receptor, serotonin transporter and dopamine transporter alterations in dogs with compulsive behaviour as a promising model for human obsessive-compulsive disorder
Simon Vermeire,Kurt Audenaert,Rudy De Meester,Eva Vandermeulen,Tim Waelbers,Bart De Spiegeleer,Jos Eersels,André Dobbeleir,Kathelijne Peremans +8 more
TL;DR: Significantly lower 5-HT2A receptor radioligand availability in frontal and temporal cortices (bilateral) was observed and abnormal DAT ratios in left and right striatum were demonstrated, suggesting its usefulness for future investigations of the pathophysiology of human OCD as well as the effectiveness of psychopharmacological interventions.
Journal ArticleDOI
Applications of positron emission tomography in animal models of neurological and neuropsychiatric disorders.
Kanwar Virdee,Paul Cumming,Daniele Caprioli,Bianca Jupp,Axel Rominger,Franklin I. Aigbirhio,Tim D. Fryer,Patrick J. Riss,Jeffrey W. Dalley +8 more
TL;DR: Significant recent breakthroughs in molecular imaging include the development of greatly improved tracers for subtypes of serotonin, cannabinoid, and metabotropic glutamate receptors, as well as noradrenaline transporters, amyloid-β and neuroinflammatory changes.
Journal ArticleDOI
Interference of anaesthetics with radioligand binding in neuroreceptor studies.
TL;DR: Ex vivo rat studies investigated the interference of ketamine/xylazine, zoletile mixture, isoflurane and halothane with the serotonin re-uptake site, the serotonin2A receptor and the dopamine re-ptake site by use of [3H]-(S)-citalopram, [18F]altanserin and [125I]PE2I, respectively and concluded that prior to performance of neuroreceptor radioligand studies
References
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Statistical methods for rates and proportions
TL;DR: In this paper, the basic theory of Maximum Likelihood Estimation (MLE) is used to detect a difference between two different proportions of a given proportion in a single proportion.
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Statistical Methods for Rates and Proportions.
B. S. Everitt,Joseph L. Fleiss +1 more
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Molecular and cellular mechanisms of general anaesthesia
TL;DR: It is now clear that anaesthetics act directly on proteins rather than on lipids, with potentiation of postsynaptic inhibitory channel activity best fitting the pharmacological profile observed in general anaesthesia.
Journal ArticleDOI
A quantitative model for the in vivo assessment of drug binding sites with positron emission tomography.
TL;DR: An in vivo method for use with positron emission tomography (PET) that results in a quantitative characterization of neuroleptic binding sites using radiolabeled spiperone, the first direct evidence that PET can be used to characterize quantitatively, locally and in vivo, drug binding sites in brain.
Journal ArticleDOI
Cocaine self-administration in dopamine-transporter knockout mice.
Beatriz Rocha,Fabio Fumagalli,Raul R. Gainetdinov,Sara R. Jones,Robert Ator,Bruno Giros,Bruno Giros,Gary W. Miller,Marc G. Caron +8 more
TL;DR: It is demonstrated that the interaction of cocaine with targets other than DAT, possibly the serotonin transporter, can initiate and sustain cocaine self-administration in these mice.