Interpretative strategies for lung function tests
Riccardo Pellegrino,Giovanni Viegi,Vito Brusasco,Robert O. Crapo,Felip Burgos,Richard Casaburi,Allan L. Coates,C.P.M. van der Grinten,P. Gustafsson,John L. Hankinson,R. Jensen,D.C. Johnson,Neil R. MacIntyre,Roy T. McKay,Martin R. Miller,Daniel Navajas,O. F. Pedersen,J. Wanger +17 more
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This section is written to provide guidance in interpreting pulmonary function tests (PFTs) to medical directors of hospital-based laboratories that perform PFTs, and physicians who are responsible for interpreting the results of PFTS most commonly ordered for clinical purposes.Abstract:
SERIES “ATS/ERS TASK FORCE: STANDARDISATION OF LUNG FUNCTION TESTING”
Edited by V. Brusasco, R. Crapo and G. Viegi
Number 5 in this Series
This section is written to provide guidance in interpreting pulmonary function tests (PFTs) to medical directors of hospital-based laboratories that perform PFTs, and physicians who are responsible for interpreting the results of PFTs most commonly ordered for clinical purposes. Specifically, this section addresses the interpretation of spirometry, bronchodilator response, carbon monoxide diffusing capacity ( D L,CO) and lung volumes.
The sources of variation in lung function testing and technical aspects of spirometry, lung volume measurements and D L,CO measurement have been considered in other documents published in this series of Task Force reports 1–4 and in the American Thoracic Society (ATS) interpretative strategies document 5.
An interpretation begins with a review and comment on test quality. Tests that are less than optimal may still contain useful information, but interpreters should identify the problems and the direction and magnitude of the potential errors. Omitting the quality review and relying only on numerical results for clinical decision making is a common mistake, which is more easily made by those who are dependent upon computer interpretations.
Once quality has been assured, the next steps involve a series of comparisons 6 that include comparisons of test results with reference values based on healthy subjects 5, comparisons with known disease or abnormal physiological patterns ( i.e. obstruction and restriction), and comparisons with self, a rather formal term for evaluating change in an individual patient. A final step in the lung function report is to answer the clinical question that prompted the test.
Poor choices made during these preparatory steps increase the risk of misclassification, i.e. a falsely negative or falsely positive interpretation for a lung function abnormality or a change …read more
Citations
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Exhaustion of Airway Basal Progenitor Cells in Early and Established Chronic Obstructive Pulmonary Disease
Moumita Ghosh,York E. Miller,Ichiro Nakachi,Jennifer B. Kwon,Anna E. Barón,Alexandra E. Brantley,Daniel T. Merrick,Wilbur A. Franklin,Robert L. Keith,R. William Vandivier +9 more
TL;DR: Basal progenitor dysfunction relates to the histologic and physiologic manifestations of COPD and identifies a subset of subjects without COPD with lung function that was midway between non‐COPD with high progenitor counts and those with COPD, indicating that progenitors exhaustion is involved in COPD pathogenesis.
Journal ArticleDOI
Lung function predicts lung cancer risk in smokers: a tool for targeting screening programmes.
Elisa Calabrò,Giorgia Randi,C. La Vecchia,Nicola Sverzellati,Alfonso Marchianò,M. Villani,Maurizio Zompatori,Roberto Cassandro,Sergio Harari,Ugo Pastorino +9 more
TL;DR: B baseline pulmonary function tests of 3,806 heavy smokers undergoing annual chest computed tomography screening are evaluated, and the forced expiratory volume in 1 s (FEV1) % predicted of 57 lung cancer cases and that of3,749 subjects without cancer are compared.
Journal ArticleDOI
Bisoprolol in patients with heart failure and moderate to severe chronic obstructive pulmonary disease: a randomized controlled trial
Nathaniel M. Hawkins,Michael R. MacDonald,Mark C. Petrie,George W. Chalmers,Roger Carter,Francis G. Dunn,John J.V. McMurray +6 more
TL;DR: Heart failure and chronic obstructive pulmonary disease frequently coexist and no study has prospectively examined the effects of beta‐blockade in those with both conditions.
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Heart rate recovery after six-minute walk test predicts pulmonary hypertension in patients with idiopathic pulmonary fibrosis
Jeffrey J. Swigris,Amy L. Olson,Oksana A. Shlobin,Shahzad Ahmad,Kevin K. Brown,Steven D. Nathan +5 more
TL;DR: It is validated that abnormal heart rate recovery at 1 min (HRR1) after six‐minute walk test (6MWT) predicts mortality and the relationship between abnormal HRR1 and pulmonary hypertension is explored.
Journal ArticleDOI
Impact of bronchodilator use on the prevalence of COPD in population-based samples.
Rogelio Pérez-Padilla,Pedro C. Hallal,Juan Carlos Vázquez-García,Adriana Muiño,María Máquez,Maria Victorina Lopez,Maria Montes de Oca,Carlos Tálamo,Gonzalo Valdivia,Julio Pertuzé,José Roberto Jardim,Ana Maria Menezes +11 more
TL;DR: The subjects who were still obstructed after bronchodilator use were the ones who showed more respiratory symptoms and exposure to tobacco and other smokes and dusts, than subjects with reversible obstruction, suggesting an increased specificity for COPD.
References
More filters
Journal ArticleDOI
Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary.
Jørgen Vestbo,Suzanne S. Hurd,Alvar Agusti,Paul W. Jones,Claus Vogelmeier,Antonio Anzueto,Peter J. Barnes,Leonardo M. Fabbri,Fernando J. Martinez,Masaharu Nishimura,Robert A. Stockley,Don D. Sin,Roberto Rodriguez-Roisin +12 more
TL;DR: It is recommended that spirometry is required for the clinical diagnosis of COPD to avoid misdiagnosis and to ensure proper evaluation of severity of airflow limitation.
Journal ArticleDOI
Standardisation of spirometry
Martin R. Miller,John L. Hankinson,Vito Brusasco,Felip Burgos,Richard Casaburi,Allan L. Coates,Robert O. Crapo,Paul L. Enright,C.P.M. van der Grinten,P. Gustafsson,R. Jensen,D.C. Johnson,Neil R. MacIntyre,Roy T. McKay,Daniel Navajas,O. F. Pedersen,Riccardo Pellegrino,Giovanni Viegi,J. Wanger +18 more
TL;DR: This research presents a novel and scalable approach called “Standardation of LUNG FUNCTION TESTing” that combines “situational awareness” and “machine learning” to solve the challenge of integrating nanofiltration into the energy system.
Journal ArticleDOI
Handbook of Physiology.
TL;DR: This is the first volume of the proposed many-sectioned "Handbook" in which the American Physiological Society intends to present comprehensively the entire field of physiology.
Journal ArticleDOI
Anthropometric standardization reference manual
TL;DR: This abridged version of the "Anthropometric Standardisation Reference Manual" contains the heart of the original manual - complete procedures for 45 anthropometric measurements.
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