Interpretative strategies for lung function tests
Riccardo Pellegrino,Giovanni Viegi,Vito Brusasco,Robert O. Crapo,Felip Burgos,Richard Casaburi,Allan L. Coates,C.P.M. van der Grinten,P. Gustafsson,John L. Hankinson,R. Jensen,D.C. Johnson,Neil R. MacIntyre,Roy T. McKay,Martin R. Miller,Daniel Navajas,O. F. Pedersen,J. Wanger +17 more
Reads0
Chats0
TLDR
This section is written to provide guidance in interpreting pulmonary function tests (PFTs) to medical directors of hospital-based laboratories that perform PFTs, and physicians who are responsible for interpreting the results of PFTS most commonly ordered for clinical purposes.Abstract:
SERIES “ATS/ERS TASK FORCE: STANDARDISATION OF LUNG FUNCTION TESTING”
Edited by V. Brusasco, R. Crapo and G. Viegi
Number 5 in this Series
This section is written to provide guidance in interpreting pulmonary function tests (PFTs) to medical directors of hospital-based laboratories that perform PFTs, and physicians who are responsible for interpreting the results of PFTs most commonly ordered for clinical purposes. Specifically, this section addresses the interpretation of spirometry, bronchodilator response, carbon monoxide diffusing capacity ( D L,CO) and lung volumes.
The sources of variation in lung function testing and technical aspects of spirometry, lung volume measurements and D L,CO measurement have been considered in other documents published in this series of Task Force reports 1–4 and in the American Thoracic Society (ATS) interpretative strategies document 5.
An interpretation begins with a review and comment on test quality. Tests that are less than optimal may still contain useful information, but interpreters should identify the problems and the direction and magnitude of the potential errors. Omitting the quality review and relying only on numerical results for clinical decision making is a common mistake, which is more easily made by those who are dependent upon computer interpretations.
Once quality has been assured, the next steps involve a series of comparisons 6 that include comparisons of test results with reference values based on healthy subjects 5, comparisons with known disease or abnormal physiological patterns ( i.e. obstruction and restriction), and comparisons with self, a rather formal term for evaluating change in an individual patient. A final step in the lung function report is to answer the clinical question that prompted the test.
Poor choices made during these preparatory steps increase the risk of misclassification, i.e. a falsely negative or falsely positive interpretation for a lung function abnormality or a change …read more
Citations
More filters
Journal ArticleDOI
Cystic fibrosis transmembrane conductance regulator channel dysfunction in non-cystic fibrosis bronchiectasis.
Thierry Bienvenu,Isabelle Sermet-Gaudelus,Pierre-Régis Burgel,Dominique Hubert,Bruno Crestani,L. Bassinet,Daniel Dusser,Isabelle Fajac +7 more
TL;DR: This study supports the hypothesis that a unique CFTR mutation may have pathogenic consequences in patients with DB and shows a continuum of airway CFTR dysfunction, ranging from normal values in healthy subjects, to intermediate values inSubjects with DB, to highly abnormal values in subjects classified as severe-CF.
Journal ArticleDOI
Exercise Pulmonary Hypertension Predicts Clinical Outcomes in Patients With Dyspnea on Effort.
Jennifer E. Ho,Emily K. Zern,Emily S. Lau,Luke Wooster,Cole S. Bailey,Thomas F Cunningham,Aaron S. Eisman,Kathryn M. Hardin,Robyn Farrell,John A. Sbarbaro,Mark W. Schoenike,Nicholas E. Houstis,Aaron L. Baggish,Ravi V. Shah,Matthew Nayor,Rajeev Malhotra,Gregory D. Lewis +16 more
TL;DR: Findings suggest incremental value of exercise hemodynamic assessment to resting measurements alone in characterizing the burden of PH in individuals with dyspnea and whether PH and PH subtypes unmasked by exercise can be used to guide targeted therapeutic interventions requires further investigation.
Journal ArticleDOI
Interpreting Lung Function Data Using 80% Predicted and Fixed Thresholds Identifies Patients at Increased Risk of Mortality
TL;DR: In this article, the authors investigated mortality in a representative sample of the US adult population with COPD by comparing abnormality determined using GOLD criteria to that determined using LLN criteria and used Cox proportional hazards models to determine the relation between lung function impairment and mortality, adjusting for covariates.
Journal ArticleDOI
Long-term Air Pollution Exposure, Genome-wide DNA Methylation and Lung Function in the LifeLines Cohort Study.
Ana Julia de Faria Coimbra Lichtenfels,Diana A van der Plaat,Kim de Jong,Cleo C. van Diemen,Dirkje S. Postma,Ivana Nedeljkovic,Cornelia M. van Duijn,Najaf Amin,Sacha la Bastide-van Gemert,Maaike de Vries,Cavin K. Ward-Caviness,Kathrin Wolf,Melanie Waldenberger,Annette Peters,Ronald P. Stolk,Bert Brunekreef,Bert Brunekreef,H. Marike Boezen,Judith M. Vonk +18 more
TL;DR: Long-term NO2 exposure was genome-wide significantly associated with DNA methylation in the identification cohort but not in the replication cohort, and future studies are needed to further elucidate the potential mechanisms underlying NO2-exposure–related respiratory disease.
Journal ArticleDOI
Respiratory function in healthy young children using forced oscillations
Graham L. Hall,Peter D. Sly,Takayoshi Fukushima,Merci Kusel,Peter Franklin,Friedrich Horak,Hilary Patterson,Catherine L. Gangell,Stephen M. Stick +8 more
TL;DR: In this paper, the authors used the forced oscillation technique to measure respiratory function in healthy young children, using a pseudo-random noise forcing signal between 4 and 48 Hz, and found that respiratory resistance and reactance did not change significantly over a 15 min period.
References
More filters
Journal ArticleDOI
Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary.
Jørgen Vestbo,Suzanne S. Hurd,Alvar Agusti,Paul W. Jones,Claus Vogelmeier,Antonio Anzueto,Peter J. Barnes,Leonardo M. Fabbri,Fernando J. Martinez,Masaharu Nishimura,Robert A. Stockley,Don D. Sin,Roberto Rodriguez-Roisin +12 more
TL;DR: It is recommended that spirometry is required for the clinical diagnosis of COPD to avoid misdiagnosis and to ensure proper evaluation of severity of airflow limitation.
Journal ArticleDOI
Standardisation of spirometry
Martin R. Miller,John L. Hankinson,Vito Brusasco,Felip Burgos,Richard Casaburi,Allan L. Coates,Robert O. Crapo,Paul L. Enright,C.P.M. van der Grinten,P. Gustafsson,R. Jensen,D.C. Johnson,Neil R. MacIntyre,Roy T. McKay,Daniel Navajas,O. F. Pedersen,Riccardo Pellegrino,Giovanni Viegi,J. Wanger +18 more
TL;DR: This research presents a novel and scalable approach called “Standardation of LUNG FUNCTION TESTing” that combines “situational awareness” and “machine learning” to solve the challenge of integrating nanofiltration into the energy system.
Journal ArticleDOI
Handbook of Physiology.
TL;DR: This is the first volume of the proposed many-sectioned "Handbook" in which the American Physiological Society intends to present comprehensively the entire field of physiology.
Journal ArticleDOI
Anthropometric standardization reference manual
TL;DR: This abridged version of the "Anthropometric Standardisation Reference Manual" contains the heart of the original manual - complete procedures for 45 anthropometric measurements.
Related Papers (5)
Standardisation of spirometry
Martin R. Miller,John L. Hankinson,Vito Brusasco,Felip Burgos,Richard Casaburi,Allan L. Coates,Robert O. Crapo,Paul L. Enright,C.P.M. van der Grinten,P. Gustafsson,R. Jensen,D.C. Johnson,Neil R. MacIntyre,Roy T. McKay,Daniel Navajas,O. F. Pedersen,Riccardo Pellegrino,Giovanni Viegi,J. Wanger +18 more