Interpretative strategies for lung function tests
Riccardo Pellegrino,Giovanni Viegi,Vito Brusasco,Robert O. Crapo,Felip Burgos,Richard Casaburi,Allan L. Coates,C.P.M. van der Grinten,P. Gustafsson,John L. Hankinson,R. Jensen,D.C. Johnson,Neil R. MacIntyre,Roy T. McKay,Martin R. Miller,Daniel Navajas,O. F. Pedersen,J. Wanger +17 more
TLDR
This section is written to provide guidance in interpreting pulmonary function tests (PFTs) to medical directors of hospital-based laboratories that perform PFTs, and physicians who are responsible for interpreting the results of PFTS most commonly ordered for clinical purposes.Abstract:
SERIES “ATS/ERS TASK FORCE: STANDARDISATION OF LUNG FUNCTION TESTING”
Edited by V. Brusasco, R. Crapo and G. Viegi
Number 5 in this Series
This section is written to provide guidance in interpreting pulmonary function tests (PFTs) to medical directors of hospital-based laboratories that perform PFTs, and physicians who are responsible for interpreting the results of PFTs most commonly ordered for clinical purposes. Specifically, this section addresses the interpretation of spirometry, bronchodilator response, carbon monoxide diffusing capacity ( D L,CO) and lung volumes.
The sources of variation in lung function testing and technical aspects of spirometry, lung volume measurements and D L,CO measurement have been considered in other documents published in this series of Task Force reports 1–4 and in the American Thoracic Society (ATS) interpretative strategies document 5.
An interpretation begins with a review and comment on test quality. Tests that are less than optimal may still contain useful information, but interpreters should identify the problems and the direction and magnitude of the potential errors. Omitting the quality review and relying only on numerical results for clinical decision making is a common mistake, which is more easily made by those who are dependent upon computer interpretations.
Once quality has been assured, the next steps involve a series of comparisons 6 that include comparisons of test results with reference values based on healthy subjects 5, comparisons with known disease or abnormal physiological patterns ( i.e. obstruction and restriction), and comparisons with self, a rather formal term for evaluating change in an individual patient. A final step in the lung function report is to answer the clinical question that prompted the test.
Poor choices made during these preparatory steps increase the risk of misclassification, i.e. a falsely negative or falsely positive interpretation for a lung function abnormality or a change …read more
Citations
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Follow-up study of a randomized controlled trial of postnatal dexamethasone therapy in very low birth weight infants: effects on pulmonary outcomes at age 8 to 11 years.
TL;DR: Postnatal DEX exposure was associated with higher expiratory flow with no adverse effects on pulmonary outcomes at school age, and Logistic regression analysis suggested that the positive effects of DEX on pulmonary function at follow-up were mediated in part by shortened exposure to mechanical ventilation.
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Energy, Forest, and Indoor Air Pollution Models for Sagarmatha National Park and Buffer Zone, Nepal.
Franco Salerno,Gaetano Viviano,Sudeep Thakuri,Bastian Flury,Ramesh Kumar Maskey,Sanjay Nath Khanal,Dinesh Raj Bhuju,Marco Carrer,Silu Bhochhibhoya,Maria Teresa Melis,Francesco Giannino,Anna Staiano,Fabrizio Cartenì,Stefano Mazzoleni,Annalisa Cogo,Atindra Sapkota,Sandeep Shrestha,Rojan Kumar Pandey,Emanuela Chiara Manfredi +18 more
TL;DR: In this article, the authors present the results of management-oriented research on energy, forest, and human health issues in a remote mountain area, the Sagarmatha National Park and Buffer Zone (SNPBZ), Nepal.
Journal ArticleDOI
Lung Volumes: Measurement, Clinical Use, and Coding
Judd D. Flesch,C. Jessica Dine +1 more
TL;DR: Measurement of lung volumes is an integral part of complete pulmonary function testing and requires knowledge of current procedural terminology (CPT) codes, relevant indications, and an appropriate level of physician supervision.
Journal ArticleDOI
Abnormal pulmonary function and associated risk factors in children and adolescents with sickle cell anemia.
Manuel Arteta,Andrew D. Campbell,Mehdi Nouraie,Sohail Rana,Onyinye Onyekwere,Gregory J. Ensing,Craig Sable,Niti Dham,Deepika S. Darbari,Lori Luchtman-Jones,Gregory J. Kato,Mark T. Gladwin,Oswaldo Castro,Caterina P. Minniti,Victor R. Gordeuk +14 more
TL;DR: Normal pulmonary function, most often obstructive, is common in children with hemoglobin SS and S&bgr;0-thalassemia, especially with history of asthma or wheezing and accentuated elevations in hemolytic markers.
Journal ArticleDOI
Decreased surfactant lipids correlate with lung function in chronic obstructive pulmonary disease (COPD).
Christina W. Agudelo,Britta K. Kumley,Estela Area-Gomez,Yimeng Xu,Abdoulaye J. Dabo,Patrick Geraghty,Michael Campos,Robert F. Foronjy,Itsaso Garcia-Arcos +8 more
TL;DR: It is shown that the surfactant lipidome is substantially altered in subjects with COPD, and decreased availability of phospholipids correlated with decreased pulmonary function, which would improve understanding of its physiopathology and reveal new potential therapeutic targets.
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Standardisation of spirometry
Martin R. Miller,John L. Hankinson,Vito Brusasco,Felip Burgos,Richard Casaburi,Allan L. Coates,Robert O. Crapo,Paul L. Enright,C.P.M. van der Grinten,P. Gustafsson,R. Jensen,D.C. Johnson,Neil R. MacIntyre,Roy T. McKay,Daniel Navajas,O. F. Pedersen,Riccardo Pellegrino,Giovanni Viegi,J. Wanger +18 more
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Standardisation of spirometry
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