Interpretative strategies for lung function tests
Riccardo Pellegrino,Giovanni Viegi,Vito Brusasco,Robert O. Crapo,Felip Burgos,Richard Casaburi,Allan L. Coates,C.P.M. van der Grinten,P. Gustafsson,John L. Hankinson,R. Jensen,D.C. Johnson,Neil R. MacIntyre,Roy T. McKay,Martin R. Miller,Daniel Navajas,O. F. Pedersen,J. Wanger +17 more
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This section is written to provide guidance in interpreting pulmonary function tests (PFTs) to medical directors of hospital-based laboratories that perform PFTs, and physicians who are responsible for interpreting the results of PFTS most commonly ordered for clinical purposes.Abstract:
SERIES “ATS/ERS TASK FORCE: STANDARDISATION OF LUNG FUNCTION TESTING”
Edited by V. Brusasco, R. Crapo and G. Viegi
Number 5 in this Series
This section is written to provide guidance in interpreting pulmonary function tests (PFTs) to medical directors of hospital-based laboratories that perform PFTs, and physicians who are responsible for interpreting the results of PFTs most commonly ordered for clinical purposes. Specifically, this section addresses the interpretation of spirometry, bronchodilator response, carbon monoxide diffusing capacity ( D L,CO) and lung volumes.
The sources of variation in lung function testing and technical aspects of spirometry, lung volume measurements and D L,CO measurement have been considered in other documents published in this series of Task Force reports 1–4 and in the American Thoracic Society (ATS) interpretative strategies document 5.
An interpretation begins with a review and comment on test quality. Tests that are less than optimal may still contain useful information, but interpreters should identify the problems and the direction and magnitude of the potential errors. Omitting the quality review and relying only on numerical results for clinical decision making is a common mistake, which is more easily made by those who are dependent upon computer interpretations.
Once quality has been assured, the next steps involve a series of comparisons 6 that include comparisons of test results with reference values based on healthy subjects 5, comparisons with known disease or abnormal physiological patterns ( i.e. obstruction and restriction), and comparisons with self, a rather formal term for evaluating change in an individual patient. A final step in the lung function report is to answer the clinical question that prompted the test.
Poor choices made during these preparatory steps increase the risk of misclassification, i.e. a falsely negative or falsely positive interpretation for a lung function abnormality or a change …read more
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Passive smoking and chronic obstructive pulmonary disease: cross-sectional analysis of data from the Health Survey for England
TL;DR: More marked dose–response relationships were observed between passive smoking exposure and respiratory symptoms, but the most marked effects were on the development of clinically significant COPD (airflow obstruction plus symptoms), where the risk among never smokers was doubled.
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Superior lung capacity in swimmers: Some questions, more answers!
B. Lazovic-Popovic,Mirjana Zlatkovic-Svenda,Tijana Durmic,Marina Djelic,S. Djordjevic Saranovic,Vladimir Zugic +5 more
TL;DR: There was significant positive correlation between age, body weight and body height and each of the above named pulmonary parameters, when presented separately for swimmers, football players and the control group.
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Pharmacogenetics of anti-inflammatory treatment in children with asthma: rationale and design of the PACMAN cohort.
Ellen S. Koster,Jan A. M. Raaijmakers,Gerard H. Koppelman,Dirkje S. Postma,Cornelis K. van der Ent,Leo Koenderman,Madelon Bracke,Anke-Hilse Maitland-van der Zee +7 more
TL;DR: The main study end point is treatment response, including asthma control, medication use and exhaled nitric oxide as a measure of airway inflammation, which allows us to also investigate other treatment response determinants, such as inhalation technique and therapy adherence.
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Methylated Genes in Sputum Among Older Smokers With Asthma
Akshay Sood,Hans Petersen,Christopher M. Blanchette,Paula Meek,Maria A. Picchi,Steven A. Belinsky,Yohannes Tesfaigzi +6 more
TL;DR: Asthma is associated with methylation of selected genes, such as protocadherin-20 gene, in sputum DNA, and novel demethylating interventions to prevent and treat asthma among older smokers may be possible.
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Bronchodilator Response Assessed by the Forced Oscillation Technique Identifies Poor Asthma Control With Greater Sensitivity Than Spirometry
Alice M. Cottee,Alice M. Cottee,Alice M. Cottee,Leigh M. Seccombe,Cindy Thamrin,Gregory G. King,Matthew J. Peters,Claude S. Farah +7 more
TL;DR: In this paper, the authors compared BDR cutoffs, using FOT and spirometry, in asthma and the relationship with asthma control and found that BDR assessed by FOT can identify poor asthma control.
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Martin R. Miller,John L. Hankinson,Vito Brusasco,Felip Burgos,Richard Casaburi,Allan L. Coates,Robert O. Crapo,Paul L. Enright,C.P.M. van der Grinten,P. Gustafsson,R. Jensen,D.C. Johnson,Neil R. MacIntyre,Roy T. McKay,Daniel Navajas,O. F. Pedersen,Riccardo Pellegrino,Giovanni Viegi,J. Wanger +18 more
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