Interpretative strategies for lung function tests
Riccardo Pellegrino,Giovanni Viegi,Vito Brusasco,Robert O. Crapo,Felip Burgos,Richard Casaburi,Allan L. Coates,C.P.M. van der Grinten,P. Gustafsson,John L. Hankinson,R. Jensen,D.C. Johnson,Neil R. MacIntyre,Roy T. McKay,Martin R. Miller,Daniel Navajas,O. F. Pedersen,J. Wanger +17 more
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This section is written to provide guidance in interpreting pulmonary function tests (PFTs) to medical directors of hospital-based laboratories that perform PFTs, and physicians who are responsible for interpreting the results of PFTS most commonly ordered for clinical purposes.Abstract:
SERIES “ATS/ERS TASK FORCE: STANDARDISATION OF LUNG FUNCTION TESTING”
Edited by V. Brusasco, R. Crapo and G. Viegi
Number 5 in this Series
This section is written to provide guidance in interpreting pulmonary function tests (PFTs) to medical directors of hospital-based laboratories that perform PFTs, and physicians who are responsible for interpreting the results of PFTs most commonly ordered for clinical purposes. Specifically, this section addresses the interpretation of spirometry, bronchodilator response, carbon monoxide diffusing capacity ( D L,CO) and lung volumes.
The sources of variation in lung function testing and technical aspects of spirometry, lung volume measurements and D L,CO measurement have been considered in other documents published in this series of Task Force reports 1–4 and in the American Thoracic Society (ATS) interpretative strategies document 5.
An interpretation begins with a review and comment on test quality. Tests that are less than optimal may still contain useful information, but interpreters should identify the problems and the direction and magnitude of the potential errors. Omitting the quality review and relying only on numerical results for clinical decision making is a common mistake, which is more easily made by those who are dependent upon computer interpretations.
Once quality has been assured, the next steps involve a series of comparisons 6 that include comparisons of test results with reference values based on healthy subjects 5, comparisons with known disease or abnormal physiological patterns ( i.e. obstruction and restriction), and comparisons with self, a rather formal term for evaluating change in an individual patient. A final step in the lung function report is to answer the clinical question that prompted the test.
Poor choices made during these preparatory steps increase the risk of misclassification, i.e. a falsely negative or falsely positive interpretation for a lung function abnormality or a change …read more
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A cross-sectional study of the prevalence and associations of iron deficiency in a cohort of patients with chronic obstructive pulmonary disease
Annabel H. Nickol,Matthew C. Frise,Hung-Yuan Cheng,Anne McGahey,Bethan M. McFadyen,Tara Harris-Wright,Nicole Karina Bart,M. Kate Curtis,Shivani Khandwala,David O'Neill,Karen A. Pollard,F. Maxine Hardinge,Najib M. Rahman,Andrew E. Armitage,Keith L. Dorrington,Hal Drakesmith,Peter J. Ratcliffe,Peter A. Robbins +17 more
TL;DR: Non-anaemic iron deficiency is common in COPD and appears to be driven by inflammation, and intravenous iron therapy should be explored as a novel therapeutic option in COPd.
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Comparison of the Prevalence of Chronic Obstructive Pulmonary Disease Diagnosed by Lower Limit of Normal and Fixed Ratio Criteria
Yong Il Hwang,Changhwan Kim,Hye Ryun Kang,Taerim Shin,Sang Myeon Park,Seung Hun Jang,Yong Bum Park,Cheol Hong Kim,Dong Gyu Kim,Myung Goo Lee,In Gyu Hyun,Ki Suck Jung +11 more
TL;DR: Implementing LLN criterion instead of fixed ratio of FEV1/FVC may reduce the risk of over-diagnosis of COPD in elderly people.
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Potential misinterpretation of infant lung function unless prospective healthy controls are studied
TL;DR: Reliable interpretation of pulmonary function tests relies on appropriate reference data, which remain very limited for infants.
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Reversible Airflow Obstruction in Lymphangioleiomyomatosis
Angelo M. Taveira-DaSilva,Wendy K. Steagall,Antoinette Rabel,Olanda Hathaway,Sergio Harari,Roberto Cassandro,Mario Stylianou,Joel Moss +7 more
TL;DR: A positive response to bronchodilators is associated with an accelerated rate of decline in pulmonary function, and a positive responses to ipratropium, albuterol, or both had significantly lower FEV(1) and Dlco decline than patients who did not respond to these bronchmodilators.
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Relationship between habit of cigarette smoking and airflow limitation in healthy Japanese individuals: the Takahata study.
Daisuke Osaka,Yoko Shibata,Shuichi Abe,Sumito Inoue,Yoshikane Tokairin,Akira Igarashi,Keiko Yamauchi,Tomomi Kimura,Michiko Sato,Hiroyuki Kishi,Noriaki Takabatake,Makoto Sata,Tetsu Watanabe,Tsuneo Konta,Sumio Kawata,Takeo Kato,Isao Kubota +16 more
TL;DR: It is concluded that cigarette smoking increases the risk of airflow limitation in a healthy Japanese population and decreases significantly with age, except for male %FVC.
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Standardisation of spirometry
Martin R. Miller,John L. Hankinson,Vito Brusasco,Felip Burgos,Richard Casaburi,Allan L. Coates,Robert O. Crapo,Paul L. Enright,C.P.M. van der Grinten,P. Gustafsson,R. Jensen,D.C. Johnson,Neil R. MacIntyre,Roy T. McKay,Daniel Navajas,O. F. Pedersen,Riccardo Pellegrino,Giovanni Viegi,J. Wanger +18 more
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