Journal ArticleDOI
Investigation of the cytotoxicity and insulin transport of acrylic-based copolymer protein delivery systems in contact with caco-2 cultures
Aaron C Foss,Nicholas A. Peppas +1 more
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The copolymers were shown to open the tight junctions between cells, increasing the available area for diffusion across the cell monolayer, and thus increasing the permeability of insulin across the monolayers.About:
This article is published in European Journal of Pharmaceutics and Biopharmaceutics.The article was published on 2004-05-01. It has received 84 citations till now. The article focuses on the topics: Ethylene glycol & Dispersion polymerization.read more
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Polymeric protein delivery systems
Kuen Yong Lee,Soon Hong Yuk +1 more
TL;DR: In this review, potential and currently used polymers for fabrication of hydrogels or polymer-modified liposomal systems and their protein delivery applications will be discussed.
Journal ArticleDOI
Role of Caco‐2 Cell Monolayers in Prediction of Intestinal Drug Absorption
TL;DR: The usefulness of Caco‐2 cell monolayers in determining the intestinal drug absorption of potential drug candidates as such and from delivery systems, elucidating the underlying mechanisms thereof, presystemic metabolism, cellular uptake and cytotoxicological assessment has been exemplified in this review.
Journal ArticleDOI
Polymeric hydrogels for oral insulin delivery
TL;DR: The present review highlights the recent findings on hydrogel-based devices for oral delivery of insulin and indicates that the micro and nanoparticle hydrogels based on biopolymers are still far from satisfactory in human insulin therapy.
Journal ArticleDOI
Novel oral insulin delivery systems based on complexation polymer hydrogels: single and multiple administration studies in type 1 and 2 diabetic rats.
Mariko Morishita,Takahiro Goto,Koji Nakamura,Anthony M. Lowman,Kozo Takayama,Nicholas A. Peppas +5 more
TL;DR: Results indicate that the blood glucose levels of diabetic rats can be effectively controlled by oral SS- ILP administration, and thus SS-ILP would be a promising delivery carrier of insulin via the oral route.
Journal ArticleDOI
Drug carriers for the delivery of therapeutic peptides.
Alice W. Du,Martina H. Stenzel +1 more
TL;DR: The different approaches to deliver peptides have been summarized where the focus is only on drug carriers based on organic materials, which is divided into surfactant-based techniques and polymer carriers.
References
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Journal ArticleDOI
Hydrogels in pharmaceutical formulations.
TL;DR: The aim of this article is to present a concise review on the applications of hydrogels in the pharmaceutical field, hydrogel characterization and analysis of drug release from such devices.
Book
Encyclopedia Of Controlled Drug Delivery
TL;DR: The 70 entries offer A-to-Z coverage of controlled drug delivery systems for researchers in the pharmaceutical and biotechnology industries, agriculture companies, medical device companies, clinical research organizations and medical schools.
Journal ArticleDOI
Physicochemical foundations and structural design of hydrogels in medicine and biology.
TL;DR: This review discusses the molecular structure, dynamic behavior, and structural modifications of hydrogels as well as the various applications of these biohydrogels.
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In Vitro Permeability Across Caco-2 Cells (Colonic) Can Predict In Vivo (Small Intestinal) Absorption in Man—Fact or Myth
TL;DR: The data suggest that Caco-2 cells developed under the culturing and transport conditions defined herein can be used to predict in vivo human absorption of compounds regardless of transport mechanism, viz., transcellular, paracellular and carrier-mediated.
Journal ArticleDOI
Advances in Biomaterials, Drug Delivery, and Bionanotechnology
Robert Langer,Nicholas A. Peppas +1 more
TL;DR: Polymers as biomaterials, materials and approaches used in drug and protein delivery systems, materials used as scaffolds in tissue engineering, and nanotechnology and microfabrication techniques applied to biomaterialS are reviewed.