Investigation, treatment and monitoring of late-onset hypogonadism in males: ISA, ISSAM, EAU, EAA and ASA recommendations
Cong-Yi Wang,Eberhard Nieschlag,Ronald S. Swerdloff,Hermann M. Behre,Wayne Jg Hellstrom,Louis Gooren,Jean-Marc Kaufman,Jean-Jacques Legros,Bruno Lunenfeld,Alvaro Morales,John E. Morley,Claude Schulman,Ian M. Thompson,Wolfgang Weidner,Frederick C. W. Wu +14 more
TLDR
In this paper, the effects of androgen treatment of hypogonadal men on multiple target organs and the recent studies show short-term beneficial effects of testosterone in older men that are similar to those in younger men.Abstract:
Demographic data clearly demonstrate that the percentage of the population in the older age group is increasing. Androgen deficiency in the aging male has become a topic of increasing interest and debate throughout the world. Cross-sectional and longitudinal data indicate that the testosterone falls progressively with age and that a significant percentage of men over the age of 60 years have serum testosterone levels that are below the lower limits of young adult (age 20–30 years) men (1–4). The principal questions raised by these observations are whether older hypogonadal men will benefit from testosterone treatment and what will be the risks associated with such intervention.
The past decade has brought evidence of benefit of androgen treatment of hypogonadal men on multiple target organs and the recent studies show short-term beneficial effects of testosterone in older men that are similar to those in younger men. This has been comprehensively reviewed and summarized by the Institute of Medicine in ‘Testosterone and Aging: Clinical Research Directions’ (5). Long-term data on the effects of testosterone treatment in the older population are limited mainly to effects on body composition and bone mass (6–11). Key questions of the effects of testosterone on patient reported outcomes and functional benefits that may retard physical or mental frailty of the elderly or improve the quality of life are not yet available. Specific risk data on the prostate and cardiovascular systems are needed.read more
Citations
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Journal ArticleDOI
Testosterone Therapy in Adult Men with Androgen Deficiency Syndromes: An Endocrine Society Clinical Practice Guideline
Shalender Bhasin,Glenn R. Cunningham,Frances J. Hayes,Alvin M. Matsumoto,Peter J. Snyder,Ronald S. Swerdloff,Victor M. Montori +6 more
TL;DR: The Task Force recommends testosterone therapy for symptomatic men with androgen deficiency, who have low testosterone levels, to induce and maintain secondary sex characteristics and to improve their sexual function, sense of well-being, muscle mass and strength, and bone mineral density.
Journal ArticleDOI
Expert consensus document: European Consensus Statement on congenital hypogonadotropic hypogonadism—pathogenesis, diagnosis and treatment
Ulrich Boehm,Pierre Bouloux,Mehul T. Dattani,Nicolas de Roux,Catherine Dodé,Leo Dunkel,Andrew A. Dwyer,Paolo Giacobini,J.-P. Hardelin,Anders Juul,Mohamad Maghnie,Nelly Pitteloud,Vincent Prevot,Taneli Raivio,Manuel Tena-Sempere,Richard Quinton,Jacques Young +16 more
TL;DR: A timely diagnosis and treatment to induce puberty can be beneficial for sexual, bone and metabolic health, and might help minimize some the psychological effects of CHH.
Journal ArticleDOI
Psychological and interpersonal dimensions of sexual function and dysfunction.
Marita P. McCabe,Stanley E. Althof,Pierre Assalian,Marie Chevret‐Measson,Sandra R. Leiblum,Chiara Simonelli,Kevan Wylie +6 more
TL;DR: The salient psychological and interpersonal issues contributing to sexual health and dysfunction are highlighted, an etiological model for understanding the evolution and maintenance of sexual symptoms is offered, and recommendations for clinical management and research are offered.
Journal ArticleDOI
Investigation, Treatment, and Monitoring of Late-Onset Hypogonadism in Males: ISA, ISSAM, EAU, EAA, and ASA Recommendations
Cong-Yi Wang,Eberhard Nieschlag,Ronald S. Swerdloff,Hermann M. Behre,Wayne Jg Hellstrom,Louis Gooren,Jean-Marc Kaufman,Jean-Jacques Legros,Bruno Lunenfeld,Alvaro Morales,John E. Morley,Claude Schulman,Ian M. Thompson,Wolfgang Weidner,Frederick C. W. Wu +14 more
TL;DR: This research presents a meta-analysis of 129 cases of meningitis in mice over a 12-month period and shows clear trends in progeria and in particular in cases of high prolapse preoperatively and during the course of pregnancy.
Journal ArticleDOI
Characteristics of Secondary, Primary, and Compensated Hypogonadism in Aging Men: Evidence from the European Male Ageing Study.
Abdelouahid Tajar,Gianni Forti,Terence W O'Neill,David Lee,Alan J. Silman,Joseph D. Finn,Gyorgy Bartfai,Steven Boonen,Felipe F. Casanueva,Aleksander Giwercman,Thang S. Han,Krzysztof Kula,Fernand Labrie,Michael E. J. Lean,Neil Pendleton,Margus Punab,Dirk Vanderschueren,Ilpo Huhtaniemi,Frederick C. W. Wu +18 more
TL;DR: Classifying LOH into different categories by combining LH with T may improve the diagnosis and management of LOH, and Symptomatic elderly men considered to have LOH can be differentiated on the basis of endocrine and clinical features and predisposing risk factors.
References
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Journal ArticleDOI
A Critical Evaluation of Simple Methods for the Estimation of Free Testosterone in Serum
TL;DR: The FT value, obtained by calculation from T and SHBG as determined by immunoassay, appears to be a rapid, simple, and reliable index of bioavailable T, comparable to AFTC and suitable for clinical routine, except in pregnancy.
Journal ArticleDOI
Longitudinal Effects of Aging on Serum Total and Free Testosterone Levels in Healthy Men
TL;DR: Observations of health factor independent, age-related longitudinal decreases in T and free T, resulting in a high frequency of hypogonadal values, suggest that further investigation of T replacement in aged men, perhaps targeted to those with the lowest serum T concentrations, are justified.
Journal ArticleDOI
Position statement: Utility, limitations, and pitfalls in measuring testosterone: An endocrine society position statement
TL;DR: Evaluated clinical assays for total and free testosterone showed that laboratory proficiency testing should be based on the ability to measure accurately and precisely samples containing known concentrations of testosterone, not only on agreement with others using the same method.
Journal ArticleDOI
Age, disease, and changing sex hormone levels in middle-aged men: results of the Massachusetts Male Aging Study.
TL;DR: Subgroup analyses suggested that obese subjects might be responsible for much of the group difference in androgen level, and serum concentrations of estrogens and cortisol did not change significantly with age or differ between groups.
Journal ArticleDOI
Testosterone Therapy in Adult Men with Androgen Deficiency Syndromes: An Endocrine Society Clinical Practice Guideline
Shalender Bhasin,Glenn R. Cunningham,Frances J. Hayes,Alvin M. Matsumoto,Peter J. Snyder,Ronald S. Swerdloff,Victor M. Montori +6 more
TL;DR: The Task Force recommends testosterone therapy for symptomatic men with androgen deficiency, who have low testosterone levels, to induce and maintain secondary sex characteristics and to improve their sexual function, sense of well-being, muscle mass and strength, and bone mineral density.
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Identification of late-onset hypogonadism in middle-aged and elderly men.
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