Journal ArticleDOI
Investigations on the structure of solid lipid nanoparticles (SLN) and oil-loaded solid lipid nanoparticles by photon correlation spectroscopy, field-flow fractionation and transmission electron microscopy
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TLDR
The investigated SLN appear as thin platelets with oil spots sticking on the surface and very short diffusion pathways in platelets, increased water-lipid interfaces and low drug incorporation in crystalline lipids are the drawback of SLN and NLC compared to conventional nanoemulsions.About:
This article is published in Journal of Controlled Release.The article was published on 2004-03-05. It has received 422 citations till now. The article focuses on the topics: Solid lipid nanoparticle & Glyceryl behenate.read more
Citations
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Design and Production of Nanoparticles Formulated From Nano-Emulsion Templates-A Review
TL;DR: A link between nano-emulsion formulation methods and nanoparticle generation is proposed, while at the same time bearing in mind the above-mentioned parameters for active molecule encapsulation.
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Potential of solid lipid nanoparticles in brain targeting.
TL;DR: The barriers to CNS drug delivery, strategies to bypass the blood-brain barrier and characterization methods of SLNs and their usefulness are discussed.
Journal ArticleDOI
Nanoemulsions for Food Applications: Development and Characterization
TL;DR: The application of nanotechnology to food, medical and pharmaceutical industries has received great attention from the scientific community as discussed by the authors, which is particularly suited for the fabrication of encapsulating systems for functional compounds as it prevents their degradation and improves their bioavailability.
Journal ArticleDOI
Lipid-Based Drug Delivery Systems in Cancer Therapy: What Is Available and What Is Yet to Come.
TL;DR: The current state of lipid-based nanoparticle research is discussed, including the development of liposomes for cancer therapy, different strategies for tumor targeting, liposomal formulation of various anticancer drugs that are commercially available, recent progress in liposome technology for the treatment of cancer, and the next generation of nanoparticles.
Journal Article
Importance of solid lipid nanoparticles (SLN) in various administration routes and future perspectives.
Melike Üner,Gülgün Yener +1 more
TL;DR: In this paper, the authors review types of solid lipid nanoparticles (SLN), principles of drug loading and models of drug incorporation, and the influence of PEG coating on particle size and surface characteristics.
References
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Journal ArticleDOI
Solid lipid nanoparticles (SLN) for controlled drug delivery - a review of the state of the art.
TL;DR: Relevant issues for the introduction of SLN to the pharmaceutical market, such as status of excipients, toxicity/tolerability aspects and sterilization and long-term stability including industrial large scale production are discussed.
Journal ArticleDOI
Solid lipid nanoparticles: Production, characterization and applications
W. Mehnert,Karsten Mäder +1 more
TL;DR: An overview about the selection of the ingredients, different ways of SLN production and SLN applications, and the in vivo fate of the carrier are presented.
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Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations.
TL;DR: As a novel type of lipid nanoparticles with solid matrix, the nanostructured lipid carriers (NLC) are presented and improvements discussed, for example, increase in loading capacity, physical and chemical long-term stability, triggered release and potentially supersaturated topical formulations.
Journal ArticleDOI
Poly(ethylene oxide)-poly(propylene oxide )-poly (ethylene oxide) block copolymer surfactants in aqueous solutions and at interfaces: thermodynamics, structure, dynamics, and modeling
TL;DR: In this article, the association properties of poly(ethylene oxide)-block-poly(propyleneoxide)-blockpoly(methylene oxide) (PEO) copolymers in aqueous solutions, and the adsorption at interfaces are reviewed.
Journal ArticleDOI
Field-flow fractionation: analysis of macromolecular, colloidal, and particulate materials
TL;DR: The principles and major subtechniques of the FFF family along with application of its measurement and separative capabilities are described.
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Solid lipid nanoparticles: Production, characterization and applications
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