Open AccessBook
Ion Channels of Excitable Membranes
TLDR
The superfamily of voltage-gated channels was studied in this paper, where a classical biophysics of the squid giant axon was discussed. But the superfamily was not considered in this paper.Abstract:
PART I Classical biophysics of the squid giant axon The superfamily of voltage-gated channels Voltage-gated calcium channels Potassium channels and chloride channels Ligand-gated channels of fast chemical synapses Modulation, slow synaptic action, and second messengers Sensory transduction and excitable cells Calcium dynamics, epithelial transport, and intercellular coupling PART II Elementary properties of ions in solution Elementary properties of pores Counting channels Structure of channel proteins Selective permeability: Independence Selective permeability: Saturation and binding Classical mechanisms of block Structure-function studies of permeation and block Gating mechanisms: Kinetic thinking Gating: Voltage sensing and inactivation Modification of gating in voltage-sensitive channels Cell biology and channels Evolution and originsread more
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Dynamical Systems in Neuroscience
TL;DR: This book explains the relationship of electrophysiology, nonlinear dynamics, and the computational properties of neurons, with each concept presented in terms of both neuroscience and mathematics and illustrated using geometrical intuition, providing a link between the two disciplines.
Journal ArticleDOI
Glutamate Receptor Ion Channels: Structure, Regulation, and Function
Stephen F. Traynelis,Lonnie P. Wollmuth,Chris J. McBain,Frank S. Menniti,Katie M. Vance,Kevin K. Ogden,Kasper B. Hansen,Hongjie Yuan,Scott J. Myers,Raymond Dingledine +9 more
TL;DR: This review discusses International Union of Basic and Clinical Pharmacology glutamate receptor nomenclature, structure, assembly, accessory subunits, interacting proteins, gene expression and translation, post-translational modifications, agonist and antagonist pharmacology, allosteric modulation, mechanisms of gating and permeation, roles in normal physiological function, as well as the potential therapeutic use of pharmacological agents acting at glutamate receptors.
Journal ArticleDOI
Channelrhodopsin-2, a directly light-gated cation-selective membrane channel.
Georg Nagel,Tanjef Szellas,Wolfram Huhn,Suneel Kateriya,Nona Adeishvili,Peter Berthold,Doris Ollig,Peter Hegemann,Ernst Bamberg +8 more
TL;DR: It is demonstrated by functional expression, both in oocytes of Xenopus laevis and mammalian cells, that ChR2 is a directly light-switched cation-selective ion channel, and may be used to depolarize small or large cells, simply by illumination.
Journal ArticleDOI
TRP channels as cellular sensors
TL;DR: TRP channels are the vanguard of the authors' sensory systems, responding to temperature, touch, pain, osmolarity, pheromones, taste and other stimuli, but their role is much broader than classical sensory transduction.
Journal ArticleDOI
Electrospinning jets and polymer nanofibers
TL;DR: In this article, the authors describe the formation and elongation of polymer nanofibers by creating and elongating an electrified fluid jet, which is often, but not necessarily constrained by an orifice, through a straight segment of a tapering cone, then through a series of successively smaller electrically driven bending coils, with each bending coil having turns of increasing radius, and finally solidifying into a continuous thin fiber.
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