Irisin ERKs the Fat
Jun Wu,Bruce M. Spiegelman +1 more
TLDR
It is shown that in vivo treatments of this recombinant protein in mice show strong anti-obesity effects and improve systematic glucose homeostasis and could represent part of the longer-lasting benefits of exercise.Abstract:
Increasing energy expenditure is an attractive approach to fighting the worldwide epidemic in obesity and type 2 diabetes. Exercise is an important component of good health and represents the first line of therapy for humans with a variety of metabolic disorders: obesity, diabetes, and nonalcoholic hepatic steatosis. Recent data has shown that exercise, besides using calories to do physical work, also causes an increase in energy expenditure through augmentation in brown fat and the browning of white fat (Fig. 1) (1,2). Indeed, these effects on brown fat could represent part of the longer-lasting benefits of exercise.
Figure 1
Recombinant irisin regulates the thermogenic program in fat through ERK and p38 pathways. Recombinant irisin produced in yeast is glycosylated and active. It induces the thermogenic gene program in 3T3-L1 cells and primary subcutaneous adipocytes. In vivo treatments of this recombinant protein in mice show strong anti-obesity effects and improve systematic glucose homeostasis.
That brown fat, in all of its dimensions, can improve type 2 diabetes and metabolic health seems to be settled science, at least in experimental animals (3). These cells express UCP1 and have a high mitochondrial content, thereby dissipating chemical energy …read more
Citations
More filters
Journal ArticleDOI
Irisin – a myth rather than an exercise-inducible myokine
Elke Albrecht,Frode Norheim,Bernd Thiede,Torgeir Holen,Tomoo Ohashi,Lisa Schering,Sindre Lee,Julia Brenmoehl,Selina Thomas,Christian A. Drevon,Harold P. Erickson,Steffen Maak +11 more
TL;DR: The results call into question all previous data obtained with commercial ELISA kits for irisin, and provide evidence against a physiological role for irisin in humans and other species.
Journal ArticleDOI
The molecular mechanisms of obesity paradox
TL;DR: The existing knowledge on the molecular mechanisms underlying the 'obesity paradox' and whether fatness can be healthy too is summarized.
Journal ArticleDOI
Interorgan Communication Pathways in Physiology: Focus on Drosophila
TL;DR: This review examines the known interorgan communication factors and their functions, physiological inducers, and integration in regulating physiology, and describes how organ-sensing screens in Drosophila can systematically identify novel conserved inter Organ communication factors.
OtherDOI
Adipose Organ Development and Remodeling
TL;DR: The plastic properties of this organ could open new therapeutic perspectives in the obesity-related metabolic disease and in breast pathologies.
Journal ArticleDOI
Irisin Lowers Blood Pressure by Improvement of Endothelial Dysfunction via AMPK‐Akt‐eNOS‐NO Pathway in the Spontaneously Hypertensive Rat
TL;DR: It is concluded that acute administration of irisin lowers blood pressure of SHRs by amelioration of endothelial dysfunction of the mesenteric artery through the AMPK‐Akt‐eNOS‐NO signaling pathway.
References
More filters
Journal ArticleDOI
Identification and Importance of Brown Adipose Tissue in Adult Humans
AM Cypess,Sanaz Lehman,Gethin Williams,Ilan Tal,Dean Rodman,Allison B. Goldfine,FC Kuo,Edwin L. Palmer,Yu-Hua Tseng,Alessandro Doria,Gerald M. Kolodny,C R Kahn +11 more
TL;DR: Defined regions of functionally active brown adipose tissue are present in adult humans, are more frequent in women than in men, and may be quantified noninvasively with the use of (18)F-FDG PET-CT.
Journal ArticleDOI
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
Pontus Boström,Jun Wu,Mark P. Jedrychowski,Anisha Korde,Li Ye,James C. Lo,Kyle A. Rasbach,Elisabeth A. Boström,Jang Hyun Choi,Jonathan Z. Long,Shingo Kajimura,Maria Cristina Zingaretti,Birgitte F. Vind,Hua Tu,Saverio Cinti,Kurt Højlund,Steven P. Gygi,Bruce M. Spiegelman +17 more
TL;DR: This article showed that PGC1α expression in muscle stimulates an increase in expression of FNDC5, a membrane protein that is cleaved and secreted as a newly identified hormone, irisin.
Journal ArticleDOI
Cold-activated brown adipose tissue in healthy men.
Wouter D. van Marken Lichtenbelt,Joost W. Vanhommerig,Nanda M Smulders,Jamie Drossaerts,Gerrit J. Kemerink,Nicole D. Bouvy,Patrick Schrauwen,G J Jaap Teule +7 more
TL;DR: Brown adipose tissue may be metabolically important in men, and the fact that it is reduced yet present in most overweight or obese subjects may make it a target for the treatment of obesity.
Journal ArticleDOI
Functional brown adipose tissue in healthy adults.
Kirsi A. Virtanen,Martin E. Lidell,Janne Orava,Mikael Heglind,Rickard Westergren,Tarja Niemi,Markku Taittonen,Jukka Laine,Nina-Johanna Savisto,Sven Enerbäck,Pirjo Nuutila +10 more
TL;DR: These findings document the presence of substantial amounts of metabolically active brown adipose tissue in healthy adult humans.
Journal ArticleDOI
FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis
ffolliott M. Fisher,Sandra Kleiner,Nicholas Douris,Elliott C. Fox,Rina J. Mepani,Francisco Verdeguer,Jun Wu,Alexei Kharitonenkov,Jeffrey S. Flier,Eleftheria Maratos-Flier,Bruce M. Spiegelman +10 more
TL;DR: It is shown here that fibroblast growth factor 21 (FGF21) plays a physiologic role in this thermogenic recruitment of WATs and acts to activate and expand the thermogenic machinery in vivo to provide a robust defense against hypothermia.