JBO-Launched and flying ahead.
Robert E. Coleman,Peyman Hadji +1 more
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TLDR
The Journal of Bone Oncology as discussed by the authors is the first journal devoted to the multidisciplinary management of bone disease in cancer patients and has received 38 manuscripts and to date accepted 25.Abstract:
Welcome to volume two of the Journal of Bone Oncology, the first journal devoted to the multidisciplinary management of bone disease in cancer patients. During the past year, the importance of bone oncology in cancer care has continued to increase. This follows the emergence of further clinical data supporting the use of bone targeted treatments in the adjuvant treatment of early breast cancer [1], [2], the activity of denosumab in delaying the development of bone metastases in castrate resistant prostate cancer [3] and clearer understanding of the risk benefits of denosumab in the prevention of skeletal morbidity in advanced cancer patients with bone metastases. [4], [5] Alongside these important clinical trial results that are already influencing clinical practice, our understanding of the importance of the bone microenvironment and the numerous cellular interactions that take place in the process of metastasis as well as the concept of tumour dormancy has expanded further [6], [7].
We are very excited by the achievements of the journal during this first year, both in terms of the number and quality of manuscripts received. An excellent and unique mix of preclinical science and clinical research in bone oncology has been addressed.
So far we have received 38 manuscripts and to date accepted 25. Of the accepted manuscripts, 13 of these were original manuscripts and 9 were reviews, supplemented by two case reports and one editorial. All three issues in volume one have been published on schedule. The high proportion of original manuscripts is particularly gratifying for a new journal and will greatly assist in developing a successful application to Medline later this year, the first critical step to negotiate in order to establish an impact factor and the long term viability of the journal.
We are extremely grateful to both our outstanding international Editorial Board who have helped promote the journal and encourage submission of high quality manuscripts and to Elsevier who have ensured the journal has achieved high visibility through Science Direct and provided a wonderfully efficient publication process. This has enabled us on average to review and publish accepted manuscripts within 3 months, providing authors with a rapid route to disseminating their research results. The future for Journal of Bone Oncology is bright and we hope you find the publication informative and relevant. We look forward to receiving your contributions to the Journal.read more
References
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Journal ArticleDOI
Denosumab and bone-metastasis-free survival in men with castration-resistant prostate cancer : results of a phase 3, randomised, placebo-controlled trial.
Matthew R. Smith,Fred Saad,Robert E. Coleman,Neal D. Shore,Karim Fizazi,Bertrand Tombal,Kurt Miller,Paul Sieber,Lawrence Karsh,Ronaldo Damião,Teuvo L.J. Tammela,Blair Egerdie,Hendrik Van Poppel,Joseph L. Chin,Juan Morote,Francisco Gomez-Veiga,Tomasz Borkowski,Zhishen Ye,Amy Kupic,Roger Dansey,Carsten Goessl +20 more
TL;DR: This large randomised study shows that targeting of the bone microenvironment can delay bone metastasis in men with prostate cancer and significantly increased bone-metastasis-free survival.
Journal ArticleDOI
Incidence, risk factors, and outcomes of osteonecrosis of the jaw: integrated analysis from three blinded active-controlled phase III trials in cancer patients with bone metastases
Fred Saad,Janet E. Brown,C. Van Poznak,Toni Ibrahim,Salomon M. Stemmer,Alison Stopeck,Ingo Diel,Shunji Takahashi,Neal D. Shore,David H. Henry,Carlos H. Barrios,T. Facon,Francis M. Senecal,Karim Fizazi,Lei Zhou,Alan H. Daniels,P. Carriere,Roger Dansey +17 more
TL;DR: In this combined analysis of three prospective trials, Osteonecrosis of the jaw was infrequent, management was mostly conservative, and healing occurred in over one-third of the patients.
Journal ArticleDOI
Superiority of denosumab to zoledronic acid for prevention of skeletal-related events: A combined analysis of 3 pivotal, randomised, phase 3 trials
Allan Lipton,Karim Fizazi,Alison Stopeck,David H. Henry,Janet E. Brown,Denise A. Yardley,Gary Richardson,Salvatore Siena,Pablo Maroto,Michael Clemens,Boris Bilynskyy,Veena Charu,Philippe Beuzeboc,Michael Rader,María Viniegra,Fred Saad,Chunlei Ke,Ada Braun,Susie Jun +18 more
TL;DR: Denosumab was superior to zoledronic acid in preventing SRE with favourable safety and convenience in patients with bone metastases from advanced cancer.
Journal ArticleDOI
Zoledronic acid (zoledronate) for postmenopausal women with early breast cancer receiving adjuvant letrozole (ZO-FAST study): final 60-month results
Robert E. Coleman,R. De Boer,H. Eidtmann,A. Llombart,Neville Davidson,Patrick Neven,G. von Minckwitz,H. P. Sleeboom,John F. Forbes,Carlos H. Barrios,Antonio Frassoldati,Ian G. Campbell,Outi Paija,N Martin,Ankita Modi,Nigel J Bundred +15 more
TL;DR: Immediate zoledronate in postmenopausal women receiving letrozole preserved BMD and is associated with improved DFS compared with letroZole alone.
Journal ArticleDOI
Oral clodronate for adjuvant treatment of operable breast cancer (National Surgical Adjuvant Breast and Bowel Project protocol B-34): a multicentre, placebo-controlled, randomised trial
Alexander H.G. Paterson,Stewart J. Anderson,Barry C. Lembersky,Louis Fehrenbacher,Carla I. Falkson,Carla I. Falkson,Karen M. King,Lorna Weir,Adam Brufsky,Shaker R. Dakhil,Thomas Lad,Luis Baez-Diaz,Julie R. Gralow,André Robidoux,Edith A. Perez,Edith A. Perez,Ping Zheng,Charles E. Geyer,Sandra M. Swain,Joseph P. Costantino,Eleftherios P. Mamounas,Norman Wolmark +21 more
TL;DR: A meta-analysis of adjuvant bisphosphonate trials is suggested before recommendations for use in non-osteoporotic postmenopausal women with primary breast cancer are made.
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