Zoledronic acid (zoledronate) for postmenopausal women with early breast cancer receiving adjuvant letrozole (ZO-FAST study): final 60-month results
Robert E. Coleman,R. De Boer,H. Eidtmann,A. Llombart,Neville Davidson,Patrick Neven,G. von Minckwitz,H. P. Sleeboom,John F. Forbes,Carlos H. Barrios,Antonio Frassoldati,Ian G. Campbell,Outi Paija,N Martin,Ankita Modi,Nigel J Bundred +15 more
TLDR
Immediate zoledronate in postmenopausal women receiving letrozole preserved BMD and is associated with improved DFS compared with letroZole alone.About:
This article is published in Annals of Oncology.The article was published on 2013-02-01 and is currently open access. It has received 291 citations till now. The article focuses on the topics: Letrozole & Zoledronic acid.read more
Citations
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Personalizing the treatment of women with early breast cancer: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2013
A. Goldhirsch,E P Winer,A S Coates,R. D. Gelber,M Piccart-Gebhart,B. Thürlimann,H.-J. Senn,Kathy S. Albain,Fabrice Andre,Jonas Bergh,Hervé Bonnefoi,Denisse Bretel-Morales,Harold J. Burstein,Fatima Cardoso,M. Castiglione-Gertsch,Alan S. Coates,Marco Colleoni,Alberto Costa,Giuseppe Curigliano,Nancy E. Davidson,Angelo Di Leo,Bent Ejlertsen,John F. Forbes,Richard D. Gelber,Michael Gnant,Aron Goldhirsch,Pamela J. Goodwin,Paul E. Goss,Jay R. Harris,Daniel F. Hayes,Clifford A. Hudis,James N. Ingle,Jacek Jassem,Zefei Jiang,Per Karlsson,Sibylle Loibl,Monica Morrow,Moïse Namer,C. Kent Osborne,Ann H. Partridge,Frédérique Penault-Llorca,Charles M. Perou,Martine Piccart-Gebhart,Kathleen I. Pritchard,Emiel J. Th. Rutgers,Felix Sedlmayer,Vladimir Semiglazov,Z Shao,Ian E. Smith,Beat Thürlimann,Masakazu Toi,Andrew Tutt,Michael Untch,Giuseppe Viale,Toru Watanabe,Nicholas Wilcken,Eric P. Winer,William C. Wood +57 more
TL;DR: The 13th St Gallen International Breast Cancer Conference (2013) Expert Panel reviewed and endorsed substantial new evidence on aspects of the local and regional therapies for early breast cancer, supporting less extensive surgery to the axilla and shorter durations of radiation therapy.
Journal ArticleDOI
Adjuvant bisphosphonate treatment in early breast cancer: meta-analyses of individual patient data from randomised trials
Joop P. W. van den Bergh,Kathleen I. Pritchard,KS Albain,Stewart J. Anderson,Rodrigo Arriagada,William E. Barlow,W. Bergsten-Nordström,Judith M Bliss,Francesco Boccardo,Rosie Bradley,Marc Buyse,David Cameron,Mike Clarke,M. Coates,Robert E. Coleman,C Correa,J. Costantino,Jack Cuzick,Neville Davidson,C Davies,A. Di Leo,Mitchell Dowsett,Marianne Ewertz,John F. Forbes,R. D. Gelber,R. Geyer,R. Gianni,M. Gnant,A. Goldhirsch,Richard Gray,Daniel F. Hayes,C. Hill,JN Ingle,Wolfgang Janni,Elizabeth MacKinnon,M. Martin,Paul McGale,Larry Norton,Yasuo Ohashi,Soonmyung Paik,Hongchao Pan,E. A. Perez,Richard Peto,R. Piccart,Lori J. Pierce,Vinod Raina,Peter M. Ravdin,J.F.R. Robertson,E.J.T. Rutgers,Joseph A. Sparano,Sandra M. Swain,Carolyn W. Taylor,Giuseppe Viale,G. von Minckwitz,Xiang Wang,Timothy J. Whelan,Nicholas Wilcken,Eric P. Winer,Norman Wolmark,William C. Wood +59 more
TL;DR: In this paper, the authors conducted a collaborative meta-analysis to clarify the risks and benefits of adjuvant bisphosphonate treatment in early breast cancer, and found that the reduction in bone recurrence was more definite (0.73-0.94; 2p=0.004).
Journal ArticleDOI
Bone health in cancer patients: ESMO Clinical Practice Guidelines
TL;DR: Through optimum multidisciplinary management of patients with bone metastases, including the use of bone-targeted treatments such as potent bisphosphonates or denosumab, it has been possible to transform the course of advanced cancer for many patients resulting in a major reduction in skeletal complications, reduced bone pain and improved quality of life.
Journal ArticleDOI
NCCN Task Force Report: Bone Health in Cancer Care
Julie Gralow,J. Sybil Biermann,Azeez Farooki,Monica Fornier,Robert F. Gagel,Rashmi Kumar,Georgia Litsas,Rana R. McKay,Donald A. Podoloff,Sandy Srinivas,Catherine Van Poznak +10 more
TL;DR: This report summarizes issues surrounding bone health in cancer care presented and discussed during this NCCN Bone Health in Cancer Care Task Force meeting in December 2012.
Journal ArticleDOI
Zoledronic acid combined with adjuvant endocrine therapy of tamoxifen versus anastrozol plus ovarian function suppression in premenopausal early breast cancer: final analysis of the Austrian Breast and Colorectal Cancer Study Group Trial 12
Michael Gnant,Brigitte Mlineritsch,Herbert Stoeger,G. Luschin-Ebengreuth,Michael Knauer,Martin Moik,Raimund Jakesz,Michael Seifert,Susanne Taucher,Vesna Bjelic-Radisic,Marija Balic,Holger Eidtmann,Wolfgang Eiermann,Günther G. Steger,Werner Kwasny,Peter Dubsky,U Selim,Florian Fitzal,Gerhard Hochreiner,Viktor Wette,Paul Sevelda,Ferdinand Ploner,Rupert Bartsch,Christian Fesl,Richard Greil +24 more
TL;DR: The final results from ABCSG 12 suggest that twice-yearly ZOL enhances the efficacy of adjuvant endocrine treatment, and this benefit is maintained long-term.
References
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Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis
Dennis M. Black,Pierre D. Delmas,Richard Eastell,Ian R. Reid,Steven Boonen,Jane A. Cauley,Felicia Cosman,Peter L. Lakatos,Ping Chung Leung,Z. Man,Carlos Mautalen,Peter Mesenbrink,Huilin Hu,John Caminis,Karen Tong,Theresa Rosario-Jansen,Joel S. Krasnow,Trisha F. Hue,Deborah E. Sellmeyer,Erik Fink Eriksen,Steven R. Cummings +20 more
TL;DR: Treatment with zoledronic acid reduced the risk of morphometric vertebral fracture by 70% during a 3-year period, as compared with placebo.
Journal ArticleDOI
Primary breast cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
Elżbieta Senkus,Stella Kyriakides,Frédérique Penault-Llorca,P.M. Poortmans,Alexander J. Thompson,Sophia Zackrisson,Fatima Cardoso +6 more
TL;DR: This work presents the results of a meta-analysis conducted at the 2016 European Oncology and Radiotherapy Guidelines Working Group (ESMO) workshop on breast cancer diagnosis and prognosis of women with atypical central giant cell granuloma (CGM) who have previously had surgery.
Journal ArticleDOI
Effect of anastrozole and tamoxifen as adjuvant treatment for early-stage breast cancer: 10-year analysis of the ATAC trial.
Jack Cuzick,Ivana Sestak,Michael Baum,Aman U. Buzdar,Anthony Howell,Mitch Dowsett,John F. Forbes +6 more
TL;DR: The Arimidex, Tamoxifen, Alone or in Combination (ATAC) trial as discussed by the authors was designed to compare the efficacy and safety of anastrozole (1 mg) with tamioxifen (20 mg) as adjuvant treatment for postmenopausal women with early stage breast cancer.
Journal ArticleDOI
Endocrine Therapy plus Zoledronic Acid in Premenopausal Breast Cancer
Michael Gnant,Brigitte Mlineritsch,Walter Schippinger,G. Luschin-Ebengreuth,Sabine Pöstlberger,Christian Menzel,Raimund Jakesz,Michael Seifert,Michael Hubalek,Vesna Bjelic-Radisic,Hellmut Samonigg,C. Tausch,Holger Eidtmann,Guenther G. Steger,Werner Kwasny,Peter Dubsky,M. Fridrik,Florian Fitzal,Michael Stierer,Ernst Rücklinger,Richard Greil +20 more
TL;DR: The addition of zoledronic acid to adjuvant endocrine therapy improves disease-free survival in premenopausal patients with estrogen-responsive early breast cancer.
Journal Article
Structure-Activity Relationships for Inhibition of Farnesyl Diphosphate Synthase in Vitro and Inhibition of Bone Resorption in Vivo by Nitrogen-Containing Bisphosphonates
James E. Dunford,Keith Thompson,Fraser P. Coxon,S. P. Luckman,F. M. Hahn,C. D. Poulter,F H Ebetino,Michael J. Rogers +7 more
TL;DR: The potency of a wider range of nitrogen-containing bisphosphonates, including the highly potent, heterocycle-containing zoledronic acid and minodronate, is examined, finding a clear correlation between the ability to inhibit farnesyl diphosphate synthase in vitro, and to inhibit protein prenylation in cell-free extracts and in purified osteoclasts in vitro and in vivo.
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Adjuvant bisphosphonate treatment in early breast cancer: meta-analyses of individual patient data from randomised trials
Joop P. W. van den Bergh,Kathleen I. Pritchard,KS Albain,Stewart J. Anderson,Rodrigo Arriagada,William E. Barlow,W. Bergsten-Nordström,Judith M Bliss,Francesco Boccardo,Rosie Bradley,Marc Buyse,David Cameron,Mike Clarke,M. Coates,Robert E. Coleman,C Correa,J. Costantino,Jack Cuzick,Neville Davidson,C Davies,A. Di Leo,Mitchell Dowsett,Marianne Ewertz,John F. Forbes,R. D. Gelber,R. Geyer,R. Gianni,M. Gnant,A. Goldhirsch,Richard Gray,Daniel F. Hayes,C. Hill,JN Ingle,Wolfgang Janni,Elizabeth MacKinnon,M. Martin,Paul McGale,Larry Norton,Yasuo Ohashi,Soonmyung Paik,Hongchao Pan,E. A. Perez,Richard Peto,R. Piccart,Lori J. Pierce,Vinod Raina,Peter M. Ravdin,J.F.R. Robertson,E.J.T. Rutgers,Joseph A. Sparano,Sandra M. Swain,Carolyn W. Taylor,Giuseppe Viale,G. von Minckwitz,Xiang Wang,Timothy J. Whelan,Nicholas Wilcken,Eric P. Winer,Norman Wolmark,William C. Wood +59 more
Adjuvant endocrine therapy plus zoledronic acid in premenopausal women with early-stage breast cancer: 62-month follow-up from the ABCSG-12 randomised trial
Michael Gnant,Brigitte Mlineritsch,Herbert Stoeger,G. Luschin-Ebengreuth,Dietmar Heck,Christian Menzel,Raimund Jakesz,Michael Seifert,Michael Hubalek,Gunda Pristauz,Thomas Bauernhofer,Holger Eidtmann,Wolfgang Eiermann,Guenther G. Steger,Werner Kwasny,Peter Dubsky,Gerhard Hochreiner,Ernst-Pius Forsthuber,Christian Fesl,Richard Greil +19 more
Endocrine Therapy plus Zoledronic Acid in Premenopausal Breast Cancer
Michael Gnant,Brigitte Mlineritsch,Walter Schippinger,G. Luschin-Ebengreuth,Sabine Pöstlberger,Christian Menzel,Raimund Jakesz,Michael Seifert,Michael Hubalek,Vesna Bjelic-Radisic,Hellmut Samonigg,C. Tausch,Holger Eidtmann,Guenther G. Steger,Werner Kwasny,Peter Dubsky,M. Fridrik,Florian Fitzal,Michael Stierer,Ernst Rücklinger,Richard Greil +20 more
Adjuvant denosumab in breast cancer (ABCSG-18): a multicentre, randomised, double-blind, placebo- controlled trial
Michael Gnant,Georg Pfeiler,Peter Dubsky,Michael Hubalek,Richard Greil,Raimund Jakesz,Viktor Wette,Marija Balic,Ferdinand Haslbauer,Elisabeth Melbinger,Vesna Bjelic-Radisic,Silvia Artner-Matuschek,Florian Fitzal,Christian Marth,Paul Sevelda,Brigitte Mlineritsch,Günther G. Steger,Diether Manfreda,Ruth Exner,Daniel Egle,Jonas Bergh,Franz Kainberger,Susan Talbot,Douglas Warner,Christian Fesl,Christian F. Singer +25 more