Journal ArticleDOI
Kinetic Resolution of α-Tertiary Propargylic Amines through Asymmetric Remote Aminations of Anilines
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This article is published in ACS Catalysis.The article was published on 2021-07-16. It has received 17 citations till now. The article focuses on the topics: Kinetic resolution.read more
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Asymmetric Synthesis of Hydroquinazolines Bearing C4-Tetrasubstituted Stereocenters via Kinetic Resolution of α-Tertiary Amines.
TL;DR: A novel protocol for asymmetric synthesis of hydroquinazolines bearing C4-tetrasubstituted stereocenters has been achieved through kinetic resolution of 2-amido α-tertiary benzylamines via chiral phosphoric acid catalyzed intramolecular dehydrative cyclizations.
Journal ArticleDOI
Kinetic resolution of N-aryl β-amino alcohols via asymmetric aminations of anilines
TL;DR: In this paper, an efficient kinetic resolution of N-aryl β-amino alcohols was developed via asymmetric para-aminations of anilines with azodicarboxylates enabled by chiral phosphoric acid catalysis.
Journal ArticleDOI
Enantioselective Synthesis of Planar-Chiral Macrocycles through Asymmetric Electrophilic Aromatic Amination.
TL;DR: Preliminary utilization of the planar-chiral macrocycle as chiral organocatalyst showcased the potential applications of these novel chiral skeletons.
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Asymmetric Aminations and Kinetic Resolution of Acyclic α-Branched Ynones
Journal ArticleDOI
Catalytic Kinetic Resolution and Desymmetrization of Amines
TL;DR: This review systematically summarized the development of kinetic resolution and desymmetrization of amines through nonenzymatic asymmetric catalytic approaches in the last two decades.
References
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Journal ArticleDOI
Efficiency in nonenzymatic kinetic resolution.
Edwin Vedejs,Mara Jure +1 more
TL;DR: The story of kinetic resolution from the early discoveries through fascinating historical milestones and conceptual developments is followed, and a focus on modern techniques that maximize efficiency is closed.
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A walk around the A3-coupling
TL;DR: This tutorial review aims to highlight the current achievements in the field of A(3)-couplings and related transformations.
Journal ArticleDOI
The Enantioselective Addition of Alkyne Nucleophiles to Carbonyl Groups
Barry M. Trost,Andrew H. Weiss +1 more
TL;DR: This review highlights and compares the available methods for the direct enantioselective addition of alkynes and metal alkynylide nucleophiles into prochiral aldehydes, ketones, and imines.
Journal ArticleDOI
Direct addition of alkynes to imines and related C=N electrophiles: A convenient access to propargylamines.
Lorenzo Zani,Carsten Bolm +1 more
TL;DR: An overview of the most significant advances in the preparation of propargylic amines via the direct addition of alkynes to imines and related carbon-nitrogen electrophiles in the presence of metal catalysts or promoters is provided.
Journal ArticleDOI
Synthesis and Reactivity of Propargylamines in Organic Chemistry
TL;DR: The different synthetic approaches to synthesize propargylamines, such as A3 couplings and C-H functionalization of alkynes, have been described and organized on the basis of the catalysts employed in the syntheses.