Journal ArticleDOI
Lectin-like oxidized low density lipoprotein receptor-1 (LOX-1) serves as an endothelial receptor for advanced glycation end products (AGE)
Reads0
Chats0
TLDR
Cellular binding experiments revealed that AGE‐bovine serum albumin (AGE‐BSA) showed the specific binding to CHO cells overexpressing bovine LOX‐1 (BLOX‐1), which was effectively suppressed by an anti‐BLox‐1 antibody.About:
This article is published in FEBS Letters.The article was published on 2002-01-30. It has received 127 citations till now. The article focuses on the topics: Advanced glycation end-product & Scavenger receptor.read more
Citations
More filters
Journal ArticleDOI
Advanced glycation end products: sparking the development of diabetic vascular injury.
TL;DR: Because of the emerging evidence about the adverse effects of AGEs on the vasculature of patients with diabetes, a number of different therapies to inhibit A GEs are under investigation.
Journal ArticleDOI
Role of advanced glycation end products in cellular signaling
TL;DR: This review will give an overview of the most prominent AGE-mediated signaling cascades, AGE receptor interactions, prevention of AGE formation and the impact of A GEs during pathophysiological processes.
Journal ArticleDOI
Cellular signalling of the receptor for advanced glycation end products (RAGE).
TL;DR: A comprehensive summary of previous and recent studies relating to the complex molecular network of RAGE signalling, with a particular emphasis on RAGE transgenic mouse models is provided.
Journal ArticleDOI
Deletion of LOX-1 Reduces Atherogenesis in LDLR Knockout Mice Fed High Cholesterol Diet
Jawahar L. Mehta,Nobuhito Sanada,Chang Ping Hu,Jiawei Chen,Abhijit Dandapat,Fumiaki Sugawara,Hiroo Satoh,Kazuhiko Inoue,Yosuke Kawase,Kou Ichi Jishage,Hiroshi Suzuki,Motohiro Takeya,Laura K. Schnackenberg,Richard D. Beger,Paul L. Hermonat,Maria Thomas,Tatsuya Sawamura +16 more
TL;DR: Generation of LOX-1 knockout mice in which binding of oxLDL to aortic endothelium was reduced and endothelia-dependent vasorelaxation preserved after treatment withOxLDL sustains endothelial function leading to a reduction in atherogenesis in association with reduction in proinflammatory and prooxidant signals.
Journal ArticleDOI
Hyperglycemia and glycation in diabetic complications.
TL;DR: The mechanism of glycation and of AGEs formation and the role of hyperglycemia, A GEs, and oxidative stress in the pathophysiology of diabetic complications are summarized.
References
More filters
Journal ArticleDOI
Efficient trace-labelling of proteins with iodine.
TL;DR: Values greater than 50 per cent can be obtained by adding oxidizing agents to liberate iodine from iodide, but most if not all of these appear to affect adversely the properties of the labelled protein.
Journal ArticleDOI
Identification of Scavenger Receptor SR-BI as a High Density Lipoprotein Receptor
Susan L. Acton,Attilio Rigotti,Katherine T. Landschulz,Shangzhe Xu,Helen H. Hobbs,Monty Krieger +5 more
TL;DR: It is shown that the class B scavenger receptor SR-BI is an HDL receptor, which mediates selective cholesterol uptake by a mechanism distinct from the classic LDL receptor pathway.
Journal ArticleDOI
Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins.
M. Neeper,Ann Marie Schmidt,J. Brett,Shi Du Yan,Feng Wang,Y.-C. E. Pan,Keith O. Elliston,David M. Stern,Alan Shaw +8 more
TL;DR: RAGE is a new member of the immunoglobulin superfamily of cell surface molecules and shares significant homology with MUC 18, NCAM, and the cytoplasmic domain of CD20 and could potentially mediate cellular effects of this class of glycosylated proteins.
Journal ArticleDOI
An endothelial receptor for oxidized low-density lipoprotein
Tatsuya Sawamura,Noriaki Kume,Takuma Aoyama,Hideaki Moriwaki,Hajime Hoshikawa,Yuichi Aiba,Tanaka Takeshi,Soichi Miwa,Yoshimoto Katsura,Toru Kita,Tomoh Masaki +10 more
TL;DR: The molecular cloning, using expression cloning strategy, of an Ox-LDL receptor from vascular endothelial cells is reported, which is a membrane protein that belongs structurally to the C-type lectin family, and is expressed in vivo in vascular endothelium and vascular-rich organs.
Journal ArticleDOI
A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection
Hiroshi Suzuki,Hiroshi Suzuki,Yukiko Kurihara,Motohiro Takeya,Nobuo Kamada,Motoyukl Kataoka,Kou-ichi Jishage,Otoya Ueda,Hisashl Sakaguchi,Takayuki Higashi,Tsukasa Suzuki,Yoshiaki Takashima,Yoshiki Kawabe,Yoshiki Kawabe,Osamu Cynshi,Youichiro Wada,Makoto Honda,Hiroki Kurihara,Hiroyuki Aburatani,Takefumi Doi,Akiyo Matsumoto,Sadahiro Azuma,Tetsuo Noda,Yutaka Toyoda,Hiroshige Itakura,Yoshio Yazaki,Seikoh Horiuchi,Kiyoshi Takahashi,J. Kar Kruijt,Theo J.C. Van Berkel,Urs P. Steinbrecher,Shun Ishibashi,Nobuyo Maeda,Siamon Gordon,Tatsuhiko Kodama +34 more
TL;DR: It is shown that targeted disruption of the MSR-A gene in mice results in a reduction in the size of atherosclerotic lesions in an animal deficient in apolipoprotein E, indicating that MSr-A may play a part in host defence against pathogens.