Left Ventricular Hypertrophy in the Renal Patient
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TLDR
Physiologically, left ventricular hypertrophy is primarily an adaptive remodeling process, compensating for an increase in workload placed on the heart with the aim of minimizing ventricular wall stress.Abstract:
Physiologically, left ventricular hypertrophy is primarily an adaptive remodeling process, compensating for an increase in workload placed on the heart with the aim of minimizing ventricular wall stress. Two contrasting models of adaptation may develop depending on the patterns of stress imposed.read more
Citations
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Journal ArticleDOI
FGF23 induces left ventricular hypertrophy
Christian Faul,Ansel P. Amaral,Behzad N. Oskouei,Ming Chang Hu,Alexis Sloan,Tamara Isakova,Orlando M. Gutiérrez,Robier Aguillon-Prada,Joy Lincoln,Joshua M. Hare,Peter Mundel,Azorides R. Morales,Julia J. Scialla,Michael J. Fischer,Michael J. Fischer,Elsayed Z. Soliman,Jing Chen,Alan S. Go,Sylvia E. Rosas,Lisa Nessel,Raymond R. Townsend,Harold I. Feldman,Martin St. John Sutton,Akinlolu O. Ojo,Crystal A. Gadegbeku,Giovana Seno Di Marco,Stefan Reuter,Dominik Kentrup,Klaus Tiemann,Marcus Brand,Joseph A. Hill,Orson W. Moe,Makoto Kuro-o,John W. Kusek,Martin G. Keane,Myles Wolf +35 more
TL;DR: It is reported that elevated FGF23 levels are independently associated with LVH in a large, racially diverse CKD cohort and suggested that chronically elevated F GF23 levels contribute directly to high rates of LVH and mortality in individuals with CKD.
Journal ArticleDOI
Fibroblast Growth Factor 23 and Left Ventricular Hypertrophy in Chronic Kidney Disease
Orlando M. Gutiérrez,James L. Januzzi,Tamara Isakova,Karen Laliberte,Kelsey Smith,Gina Collerone,Ammar Sarwar,Udo Hoffmann,Erin Coglianese,Robert H. Christenson,Thomas J. Wang,Christopher DeFilippi,Myles Wolf +12 more
TL;DR: FGF-23 is independently associated withleft ventricular mass index and left ventricular hypertrophy in patients with CKD, and whether increased FGF- 23 is a marker or a potential mechanism of myocardial hyperTrophy in CKD requires further study.
Journal ArticleDOI
Endogenous Cardiotonic Steroids: Physiology, Pharmacology, and Novel Therapeutic Targets
TL;DR: The physiological interactions between CTS and other regulatory systems that may be important in the pathophysiology of essential hypertension, preeclampsia, end-stage renal disease, congestive heart failure, and diabetes mellitus are focused on.
Journal ArticleDOI
Cardiovascular Disease in Chronic Kidney Disease: Pathophysiological Insights and Therapeutic Options.
TL;DR: The authors explore the most important interactions between heart rhythm disorders and renal dysfunction while evaluating the ways in which the coexistence of renal dysfunction and cardiac arrhythmia influences the management of both.
Journal ArticleDOI
Fibroblast Growth Factor-23 and Cardiovascular Events in CKD
Julia J. Scialla,Huiliang Xie,Mahboob Rahman,Amanda H. Anderson,Tamara Isakova,Akinlolu O. Ojo,Xiaoming Zhang,Lisa Nessel,Takayuki Hamano,Juan E. Grunwald,Dominic S. Raj,Wei Yang,Jiang He,James P. Lash,Alan S. Go,John W. Kusek,Harold I. Feldman,Myles Wolf +17 more
TL;DR: Elevated FGF-23 was associated more strongly with CHF than with atherosclerotic events, and uniformly was associated with greater risk of CHF events across subgroups stratified by eGFR, proteinuria, prior heart disease, diabetes, BP control, anemia, sodium intake, income, fat-free mass, left ventricular mass index, and ejection fraction.
References
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Relation of Left Ventricular Mass and Geometry to Morbidity and Mortality in Uncomplicated Essential Hypertension
TL;DR: Echocardiographically determined left ventricular mass and geometry stratify risk in patients with essential hypertension independently of and more strongly than blood pressure or other potentially reversible risk factors and may help to stratify the need for intensive treatment.
Journal ArticleDOI
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TL;DR: This study concludes that a large percentage of hemodialysis patients who have a serum phosphorus level above 6.5 mg/dL and that this places them at increased risk of death, and supports the need for vigorous control of hyperphosphatemia to improve patient survival.
Journal ArticleDOI
The effects of normal as compared with low hematocrit values in patients with cardiac disease who are receiving hemodialysis and epoetin.
Anatole Besarab,W K Bolton,J K Browne,Joan C. Egrie,Allen R. Nissenson,D M Okamoto,Steve J. Schwab,David A. Goodkin +7 more
TL;DR: In patients with clinically evident congestive heart failure or ischemic heart disease who are receiving hemodialysis, administration of epoetin to raise their hematocrit to 42 percent is not recommended.
Journal ArticleDOI
Accelerated Atherosclerosis in Prolonged Maintenance Hemodialysis
TL;DR: The survival experience of 39 patients receiving long-term regular hemodialysis in Seattle since 1960 was studied with particular reference to mortality and morbidity from arteriosclerotic...
Journal ArticleDOI
Clinical and echocardiographic disease in patients starting end-stage renal disease therapy
Robert N. Foley,Patrick S. Parfrey,Patrick S. Parfrey,John D. Harnett,John D. Harnett,Gloria M. Kent,Gloria M. Kent,Christopher J. Martin,Christopher J. Martin,David C. Murray,David C. Murray,Paul E. Barre,Paul E. Barre +12 more
TL;DR: It is concluded that clinical and echocardiographic cardiovascular disease are already present in a very high proportion of patients starting ESRD therapy and are independent mortality factors.