Leukocytes of pregnant women with small-for-gestational age neonates have a different phenotypic and metabolic activity from those of women with preeclampsia
Giovanna Ogge,Roberto Romero,Tinnakorn Chaiworapongsa,Maria Teresa Gervasi,Percy Pacora,Offer Erez,Juan Pedro Kusanovic,Edi Vaisbuch,Shali Mazaki-Tovi,Francesca Gotsch,Pooja Mittal,Yeon Mee Kim,Sonia S. Hassan +12 more
TLDR
Pregnancies complicated by the delivery of an SGA neonate are characterized by a higher activation of maternal peripheral leukocytes than in normal pregnancies, but lower than in pregnancies complicated by preeclampsia.Abstract:
Objective. Preeclampsia and pregnancies complicated by small-for-gestational age (SGA) neonates share several underlying mechanisms of disease. However, while an exaggerated systemic maternal inflammatory response is regarded as one of the hallmarks of the pathogenesis of preeclampsia, the presence of a similar systemic intra-vascular inflammation in mothers of SGA neonates without hypertension is controversial. The aim of this study was to determine phenotypic and metabolic changes in granulocytes and monocytes of women who develop preeclampsia and those who deliver an SGA neonate, compared to normal pregnant women.Methods. This cross-sectional study included patients with a normal pregnancy (n = 33), preeclampsia (n = 33), and an SGA without preeclampsia (n = 33), matched for gestational age at blood sample collection. Granulocyte and monocyte phenotypes were determined by flow cytometry, using monoclonal antibodies against selective cluster of differentiation (CD) antigens. The panel of antibodies incl...read more
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Pre-eclampsia part 1: current understanding of its pathophysiology
TL;DR: The diagnosis, classification, clinical manifestations and putative pathogenetic mechanisms of pre-eclampsia are discussed.
Journal ArticleDOI
Placental Viral Infection Sensitizes to Endotoxin-Induced Pre-Term Labor: A Double Hit Hypothesis
Ingrid Cardenas,Gil Mor,Paulomi Aldo,Sabine Lang,Paul R. Stabach,Andrew Sharp,Roberto Romero,Shali Mazaki-Tovi,Maria-Teresa Gervasi,Robert E. Means +9 more
TL;DR: Citation Cardenas I, Mor G, Aldo P, Lang SM, Stabach P, Sharp A, Romero R, Mazaki‐Tovi S, Gervasi MTeresa, Means RE Placental viral infection sensitizes to endotoxin‐induced pre‐term labor: a double hit hypothesis.
Journal ArticleDOI
Failure of physiologic transformation of spiral arteries, endothelial and trophoblast cell activation, and acute atherosis in the basal plate of the placenta
Carlos A. Labarrere,Hector L. DiCarlo,Elaine Bammerlin,James W. Hardin,Yeon Mee Kim,Piya Chaemsaithong,David M. Haas,Ghassan S. Kassab,Roberto Romero +8 more
TL;DR: In this article, the authors found that failure of spiral artery physiologic transformation was associated with activation of interstitial extravillous trophoblasts and/or spiral artery endothelium and presence of acute atherosis in the placental basal plate.
Journal ArticleDOI
Microbial invasion of the amniotic cavity in pregnancies with small-for-gestational-age fetuses.
Daniel B. DiGiulio,Maria Teresa Gervasi,Roberto Romero,Edi Vaisbuch,Shali Mazaki-Tovi,Juan Pedro Kusanovic,Kimberley S. Seok,Ricardo Gomez,Pooja Mittal,Francesca Gotsch,Tinnakorn Chaiworapongsa,E. Oyarzun,Chong Jai Kim,David A. Relman +13 more
TL;DR: MIAC is detected by PCR in some patients with an SGA fetus who were not in labor at the time of AF collection, and intra-amniotic inflammation was detected in one of the three patients with a positive PCR result, as compared with two patients with both a negative culture and a negative PCR result.
Journal ArticleDOI
The frequency of acute atherosis in normal pregnancy and preterm labor, preeclampsia, small-for-gestational age, fetal death and midtrimester spontaneous abortion.
Yeon Mee Kim,Piya Chaemsaithong,Roberto Romero,Majid Shaman,Chong Jai Kim,Jung Sun Kim,Faisal Qureshi,Suzanne M. Jacques,Ahmed I. Ahmed,Tinnakorn Chaiworapongsa,Sonia S. Hassan,Lami Yeo,Steven J. Korzeniewski +12 more
TL;DR: Acute atherosis is rare in normal pregnancy, and occurs more frequently in patients with pregnancy complications, including preeclampsia, sPTL, preterm PROM, midtrimester spontaneous abortion, fetal death and SGA.
References
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