Journal ArticleDOI
Limits on oral transmission of HIV-1
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TLDR
The potential of acquiring an HIV-1 infection through an oral route is discussed, with a view of offering clues for its prevention, in a study of adult animals given low concentration cell-free simian immunodeficiency virus orally.About:
This article is published in The Lancet.The article was published on 2000-07-22. It has received 36 citations till now. The article focuses on the topics: Saliva.read more
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Journal ArticleDOI
HIV infection and periodontal diseases: an overview of the post-HAART era
TL;DR: The current literature suggests that the prevalence and course of periodontal lesions have also been modified, and higher prevalence of opportunistic microorganisms has been frequently detected in the subgingival flora of HIV- infected individuals, probably due to the immune status of those patients.
Journal ArticleDOI
Human Immunodeficiency Virus Type 1 Stimulates the Expression and Production of Secretory Leukocyte Protease Inhibitor (SLPI) in Oral Epithelial Cells: a Role for SLPI in Innate Mucosal Immunity
TL;DR: This first report of SLPI regulation by HIV-1 shows that the expression and production of the antimicrobial and anti-inflammatory protein can be stimulated in oral epithelial cells by the virus through interactions with gp120 in the absence of direct infection.
Journal ArticleDOI
Determinants of Protection among HIV-Exposed Seronegative Persons: An Overview
Michael M. Lederman,Galit Alter,Demetre Daskalakis,Benigno Rodriguez,Scott F. Sieg,Gareth Hardy,Michael Cho,Donald D. Anthony,Clifford V. Harding,Aaron Weinberg,Robert H. Silverman,Daniel C. Douek,Leonid Margolis,David B. Goldstein,Mary Carrington,James J. Goedert +15 more
TL;DR: Clinical experience and a growing medical literature indicate that some persons who have been exposed to human immunodeficiency virus (HIV) infection remain uninfected, and clarifying the determinants of protection against HIV infection is a high priority that will require careful selection of high‐risk uninfecting cohorts.
Journal ArticleDOI
Increase in HIV Receptors/Co-receptors/α-defensins in Inflamed Human Gingiva
TL;DR: Low expression of HIV-1 co-receptors in health and high expression of α-defensin during CP may comprise endogenous factors that provide protection from oral HIV- 1 infection.
Journal ArticleDOI
Preventing Sexual Transmission of HIV
TL;DR: Factors that define HIV infectivity and susceptibility and factors that amplify the risk of HIV transmission, may serve as critical targets for containment of the HIV epidemic.
References
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Journal ArticleDOI
Clinical and epidemiologic features of primary HIV infection.
TL;DR: The events leading to the acquisition of HIV and the initial clinical and diagnostic evaluation of 46 patients with primary HIV infection are summarized.
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Sexual transmission of HIV
TL;DR: The epidemiology and biology of the host-related factors that affect the sexual transmission of HIV and the host susceptibility and infectiousness environment biologic agent are discussed.
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Effect of breastfeeding and formula feeding on transmission of HIV-1: a randomized clinical trial.
Ruth Nduati,Grace John,Dorothy Mbori-Ngacha,Barbra A. Richardson,Julie Overbaugh,Anthony Mwatha,Jeckoniah O. Ndinya-Achola,Job J. Bwayo,F E Onyango,James P. Hughes,Joan K. Kreiss +10 more
TL;DR: The frequency of breast milk transmission of HIV-1 was 16.2% in this randomized clinical trial, and the majority of infections occurred early during breastfeeding, which prevented 44% of infant infections and was associated with significantly improved HIV‐1‐free survival.
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Human Immunodeficiency Virus Load in Breast Milk, Mastitis, and Mother-to-Child Transmission of Human Immunodeficiency Virus Type 1
Richard D. Semba,Newton Kumwenda,Donald R. Hoover,Taha E. Taha,Thomas C. Quinn,Thomas C. Quinn,Laban A.R. Mtimavalye,Robert J. Biggar,Robin L. Broadhead,Paolo G. Miotti,Lori J. Sokoll,Len van der Hoeven,John D. Chiphangwi +12 more
TL;DR: Mastitis and breast milk HIV-1 load may increase the risk of vertical transmission of HIV- 1 through breast-feeding.
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Inhibition of Human Immunodeficiency Virus Type 1 Infectivity by Secretory Leukocyte Protease Inhibitor Occurs Prior to Viral Reverse Transcription
T B McNeely,Diane C. Shugars,Mary S. Rosendahl,Christina Tucker,Stephen P. Eisenberg,Sharon M. Wahl +5 more
TL;DR: The unique antiviral activity of SLPI, which may be independent of its previously characterized antiprotease activity, appears to reside in disruption of the viral infection process soon after virus binding.