Journal ArticleDOI
Linear correlation between rheological, mechanical and mucoadhesive properties of polycarbophil polymer blends for biomedical applications
Sabrina Barbosa de Souza Ferreira,Jéssica Bassi da Silva,Fernanda Belincanta Borghi-Pangoni,Mariana Volpato Junqueira,Marcos Luciano Bruschi +4 more
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TLDR
Rheological, mechanical and mucoadhesive characterization provided a rational basis for selecting appropriated systems, useful for muco-adhesive drug delivery systems and biomedical applications.Abstract:
Polycarbophil is widely used in a variety of pharmaceutical formulations, mainly for their strong ability to adhere to the epithelial and mucous barriers (bio/mucoadhesion). On the other hand, its association with the thermoresponsive polymer (poloxamer 407) has been poorly explored. This work investigates the rheological, mechanical and mucoadhesive properties of polymer blends containing polycarbophil and poloxamer 407, in order to select the best formulations for biomedical and pharmaceutical applications. Mechanical (hardness, compressibility, adhesiveness, softness, and mucoadhesion) and rheological characteristics (consistency index, yield value and hysteresis area) showed that 20% (w/w) poloxamer 407- polymer blends exhibited higher values parameters. However, the rheological interaction parameter, which was more sensible than the mechanical interaction parameter, revealed higher synergism for systems comprising 15% (w/w) poloxamer 407, due to the system organization and polymers' properties. Furthermore, gelation temperatures were appropriated, suggesting that polymer blends can be used as biomedical materials, and displaying easy administration, enhanced retention and prolonged residence time at the site of application. Therefore, rheological, mechanical and mucoadhesive characterization provided a rational basis for selecting appropriated systems, useful for mucoadhesive drug delivery systems and biomedical applications.read more
Citations
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Poloxamer-based in situ gelling thermoresponsive systems for ocular drug delivery applications.
TL;DR: The sol-gel transition temperature, mucoadhesive properties, and drug release profiles of poloxamer-based in situ gels can be finely tuned, enabling them to be used as vehicles for the delivery of small and large drug molecules to treat diseases of the anterior and posterior segments of the eye.
Journal ArticleDOI
Assessing Mucoadhesion in Polymer Gels: The Effect of Method Type and Instrument Variables.
Jéssica Bassi da Silva,Sabrina Barbosa de Souza Ferreira,Adriano V. Reis,Michael T. Cook,Marcos Luciano Bruschi +4 more
TL;DR: The aim of this work was to standardize the conditions of the detachment test and the rheological methods of mucoadhesion assessment for semisolids, and introduce a texture profile analysis (TPA) method to be reproducible and evaluate the adhesiveness interaction parameter.
Journal ArticleDOI
Ferromagnetic soft catheter robots for minimally invasive bioprinting
Zhou Cheng,Yang Youzhou,Jiaxin Wang,Qingyang Wu,Gu Zhuozhi,Zhou Yuting,Liu Xurui,Yueying Yang,Hanchuan Tang,Qing Ling,Liu Wang,Jianfeng Zang +11 more
TL;DR: In this paper, a ferromagnetic soft catheter robot (FSCR) is designed to print multiple patterns on planar surfaces, and considering the non-planar surface of natural organs, they then develop an in situ printing strategy for curved surfaces and demonstrate minimally invasive in vivo bioprinting of hydrogels in a rat model.
Journal ArticleDOI
Nanostructured lipid systems modified with waste material of propolis for wound healing: Design, in vitro and in vivo evaluation.
Hélen Cássia Rosseto,Lucas de Alcântara Sica de Toledo,Lizziane Maria Belloto de Francisco,Elisabetta Esposito,Yunsook Lim,Giuseppe Valacchi,Rita Cortesi,Marcos Luciano Bruschi +7 more
TL;DR: In this article, solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) were used as topical propolis delivery systems and the investigation of their in vitro and in vivo activities was conducted.
Journal ArticleDOI
Rheological analysis and mucoadhesion: A 30 year-old and still active combination
Silvia Rossi,Barbara Vigani,Maria Cristina Bonferoni,Giuseppina Sandri,Carla Caramella,Franca Ferrari +5 more
TL;DR: The scientific path that, since the beginning of the 90s, has led to the affirmation of the rheological analysis as a useful tool for the evaluation of the strength of the mucoadhesive bond is retraced.
References
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Journal ArticleDOI
A Review of Poloxamer 407 Pharmaceutical and Pharmacological Characteristics
TL;DR: New findings have demonstrated immuno-modulation and cytotoxicity-promoting properties of Poloxamer 407 revealing significant pharmacological interest and, hence, human trials are in progress to specify these potential applications.
Journal ArticleDOI
Artificial skin I. Preparation and properties of Pluronic F-127 gels for treatment of burns
TL;DR: The preparation of block polymer surface-active agents derived solely from propylene oxide and ethylene oxide, and the physical properties of a nonionic surfactant of 12,500 molecular weight, Pluronic F-127, are presented.
Journal ArticleDOI
Mucoadhesive polymeric platforms for controlled drug delivery
TL;DR: The success and degree of muco-adhesive bonding is influenced by various polymer-based properties such as the degree of cross-linking, chain length and the presence of various functional groupings as mentioned in this paper.
Journal ArticleDOI
Mucoadhesive drug delivery systems.
Rahamatullah Shaikh,Thakur Raghu Raj Singh,Martin J. Garland,A. David Woolfson,Ryan F. Donnelly +4 more
TL;DR: This review article aims to provide an overview of the various aspects of mucoadhesion,Mucoadhesive materials, factors affecting muco adhesion, evaluating methods, and finally various mucoADhesive drug delivery systems (buccal, nasal, ocular, gastro, vaginal, and rectal).
Journal ArticleDOI
Smart polymers for the controlled delivery of drugs - a concise overview.
TL;DR: Various mechanisms by which polymer systems are assembled in situ to form implanted devices for sustained release of therapeutic macromolecules are discussed, and various applications in the field of advanced drug delivery are highlighted.