Journal ArticleDOI
Semisolid Systems Containing Propolis for the Treatment of Periodontal Disease: In Vitro Release Kinetics, Syringeability, Rheological, Textural, and Mucoadhesive Properties
Marcos Luciano Bruschi,David S. Jones,Heitor Panzeri,Maria Palmira Daflon Gremião,Osvaldo de Freitas,Elza Helena Guimarães Lara +5 more
TLDR
The data obtained in these formulations indicate a potentially useful role in the treatment of periodontitis and suggest they are worthy of clinical evaluation.About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 2007-08-01. It has received 205 citations till now.read more
Citations
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Journal ArticleDOI
Polymeric materials with antimicrobial activity
TL;DR: The state of the art in the field of antimicrobial polymeric systems during the last decade is described in this paper, where a classification of the different materials is carried out dividing basically those synthetic polymers that exhibit antimicrobial activity by themselves; those whose biocidal activity is conferred through their chemical modification; those that incorporate antimicrobial organic compounds with either low or high molecular weight; and those that involve the addition of active inorganic systems.
Journal ArticleDOI
Thixotropic property in pharmaceutical formulations.
TL;DR: The comprehensive analysis of rheological and mechanical properties will provide an insight into the potential usage of thixotropic formulations as drug delivery systems.
Journal ArticleDOI
A poloxamer/chitosan in situ forming gel with prolonged retention time for ocular delivery.
Tais Gratieri,Guilherme M. Gelfuso,Eduardo Rocha,Victor Hugo Vitorino Sarmento,Osvaldo de Freitas,Renata Fonseca Vianna Lopez +5 more
TL;DR: The in situ forming gel comprised of poloxamer/chitosan is a promising tool for the topical treatment of ocular diseases and presents adequate mechanical and sensorial properties and remained in contact with the eye surface for a prolonged time.
Journal ArticleDOI
Mucoadhesive drug delivery systems
Flávia Chiva Carvalho,Marcos Luciano Bruschi,Raul Cesar Evangelista,Maria Palmira Daflon Gremião +3 more
TL;DR: The aim of this study was to review the mechanisms and theories involved in mucoadhesion, as well as to describe the most-used methodologies and polymers inMucoadhesive drug delivery systems.
Journal ArticleDOI
Recent approaches for the treatment of periodontitis
Nilu Jain,Gaurav K. Jain,Shamama Javed,Zeenat Iqbal,Sushama Talegaonkar,Farhan Jalees Ahmad,Roop K. Khar +6 more
TL;DR: This review summarises the recent developments in the field of intra-pocket drug delivery systems and identifies areas where further research may lead to a clinically effective intra- pocket delivery system.
References
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Journal ArticleDOI
Mechanism of sustained‐action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices
TL;DR: The analyses suggest that for the latter system the time required to release 50% of the drug would normally be expected to be approximately 10 per cent of that required to dissolve the last trace of the solid drug phase in the center of the pellet.
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A simple equation for description of solute release II. Fickian and anomalous release from swellable devices
TL;DR: In this paper, an exponential relation M t /M ∞ = kt n may be used to describe the Fickian and non-Fickian release behavior of release systems which are prepared by incorporation of a drug in a hydrophilic, initially glassy polymer.
Book
An Introduction To Rheology
TL;DR: In this article, the authors discuss the importance of non-linearity solids and liquids rheology is a difficult subject for rheological research, and present some demonstrations of high extensional viscosity behaviour.
Journal ArticleDOI
Review of the biological properties and toxicity of bee propolis (propolis)
TL;DR: Although reports of allergic reactions are not uncommon, propolis is relatively non-toxic, with a no-effect level (NOEL) in a 90-mouse study of 1400 mg/kg body weight/day.
Journal ArticleDOI
Antibacterial, antifungal and antiviral activity of propolis of different geographic origin.
TL;DR: It seems that propolis has general pharmacological value as a natural mixture and not as a source of new powerful antimicrobial, antifungal and antiviral compounds.