Journal ArticleDOI
Linolenic acid deficiency.
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TLDR
In this article, it was shown that Linolenic acid deficiency has not been demonstrated clearly in warm blooded animals, yet circumstantial evidence suggests that n-3 fatty acids may have functions in these animals.Abstract:
Linolenic acid deficiency has not been demonstrated clearly in warm blooded animals, yet circumstantial evidence suggests that n-3 fatty acids may have functions in these animals. The fact that several species of fish definitely require dietary n-3 fatty acids indicates that n-3 fatty acids have important and specific functions in these animals and suggests that such functions may also be present in warm blooded animals. It is also true that n-3 fatty acid distribution in tissues of birds and mammals appears to be under strict metabolic control, and that this complex metabolic control mechanism apparently has survived evolutionary pressure for a very long time. So far, attempts to produce linolenic acid deficiency in mammals have not revealed an absolute requirement for n-3 fatty acids. If functions for n-3 fatty acids do exist in warm blooded animals, it seems probable that they may be located in the cerebral cortex or in the retina, because these tissues normally contain high concentrations of n-3 fatty acids.read more
Citations
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The modification of mammalian membrane polyunsaturated fatty acid composition in relation to membrane fluidity and function
Journal ArticleDOI
Intrauterine fatty acid accretion rates in human brain: implications for fatty acid requirements
TL;DR: Developmental changes and estimates of fatty acid incorporation into whole brain and cerebellum are quantitatively relevant to estimation of fatty acids requirements of the low birth weight neonate.
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Dietary omega-3 fatty acid deficiency and visual loss in infant rhesus monkeys.
TL;DR: The results suggest that omega-3 fatty acids may be an essential nutrient, and that 22:6 omega 3 may have a specific function in the photoreceptor membranes of the retina.
Journal ArticleDOI
Effect of dietary alpha-linolenate/linoleate balance on brain lipid compositions and learning ability of rats.
TL;DR: The dietary alpha-linolenate/linoleate balance influenced the (n-3)/(n-6) balance of polyenoic fatty acids differently among brain phospholipids, resulting in higher response ratios in the perilla oil groups.
References
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Journal ArticleDOI
Distribution and fatty acid composition of phosphoglycerides in normal human brain
TL;DR: Brain inositol phosphoglycerides, the fatty acid composition of which has not been studied systematically before, were characterized by a large concentration of arachidonate which was nearly as high for white as for gray matter and showed only small changes with age.
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Thromboxanes: selective biosynthesis and distinct biological properties
TL;DR: The observations indicate the remarkable structural specificity of both the synthetic enzymes, cyclooxygenase and thromboxane synthetase, as well as the vascular and platelet receptor sites.
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Visual membranes: specificity of fatty acid precursors for the electrical response to illumination
TL;DR: Rat electroretinograms were measured as a function of dietary supplements of purified ethyl esters of linolenic Acid, linoleic acid, and oleic acid to investigate the electrical response of photoreceptor cell membranes to polyunsaturated fatty acids derived from precursors.
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A Possible Essential Role for Dietary Linolenic Acid in the Development of the Young Rat
TL;DR: The association of superior learning capacity with dietary soybean oil-induced incorporation of omega3 fatty acids into the brain glycerophosphatides is offered as support for an essential role for dietary linolenic acid for the young rat.
Journal ArticleDOI
Coronary tone modulation: formation and actions of prostaglandins, endoperoxides, and thromboxanes.
TL;DR: Coronary tone, and possible spasm, in ischemic myocardial zones may be influenced markedly by interplay between prostaglandins, endoperoxides, and thromboxane formed by platelets on the one hand, and endoperoxide products synthesized endogenously in the coronary arteries on the other.
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