Journal ArticleDOI
Lipid Nanocarrier: an Efficient Approach Towards Ocular Delivery of Hydrophilic Drug (Valacyclovir).
Rakesh Kumar,V. R. Sinha +1 more
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TLDR
Improved ocular bioavailability of VAC from SLN-6 is confirmed and the potential of SLNs in efficient ocular delivery of a hydrophilic molecule like VAC is suggested.Abstract:
This research focuses on the fabrication and evaluation of solid lipid nanoparticles (SLNs) for improved ocular delivery of valacyclovir (VAC). Stearic acid and tristearin were selected as the lipid carrier while Poloxamer 188 and sodium taurocholate were used as surfactant and co-surfactant, respectively. The physiochemical properties of the optimized batch (SLN-6) fulfil the prerequisites needed for an ideal ocular formulation like submicron size (202.5 ± 2.56 nm), narrow PDI (0.252 ± 0.06), high zeta potential (−34.4 ± 3.04 mV) and good entrapment efficiency (58.82 ± 2.45%). The in vitro release study of SLN-6 exhibited a sustained release profile (>60% in 12 h). The ex vivo studies performed on excised cornea exhibited enhanced drug permeation of SLNs (22.17 ± 1.41 μg/cm2 h) in comparison to the drug solution (3.78 ± 1.34 μg/cm2 h). Apart, the corneal hydration studies, histopathology and Hen’s Egg Test Chorio Allantoic Membrane (HETCAM) assay, confirmed the non-irritancy of SLNs. The in vivo study confirmed improved ocular bioavailability of VAC from SLN-6 (AUC0–12: 856.47 ± 7.86 μg h/mL) in contrast to the drug solution (AUC0–12: 470.75 ± 8.91 μg h/mL). Hence, the overall studies suggested the potential of SLNs in efficient ocular delivery of a hydrophilic molecule like VAC.read more
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Journal ArticleDOI
Solid lipid nanoparticles as promising tool for intraocular tobramycin delivery: Pharmacokinetic studies on rabbits.
Patrizia Chetoni,Susi Burgalassi,Daniela Monti,Silvia Tampucci,Vivian Tullio,Annamaria Cuffini,Elisabetta Muntoni,Rita Spagnolo,Gian Paolo Zara,Roberta Cavalli +9 more
TL;DR: Whether tobramycin as ion-pair incorporated in mucoadhesive Solid Lipid Nanoparticles (SLN) reaches the inner parts of the eye favoring drug activity is determined and the knowledge on the use of SLN as carriers for ocular drug delivery to the posterior chamber is broadened.
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Lida Lalu,Vishakha Tambe,Deepak Pradhan,Kritika Nayak,Suchandra Bagchi,Rahul Maheshwari,Kiran Kalia,Rakesh K. Tekade +7 more
TL;DR: In this review, the recent attempts of nanotechnology‐based systems for treating and managing various ocular ailments are highlighted and may pave the way to new, highly effective and vital ocular nanosystems.
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TL;DR: FT-IR spectra of Met-SLN showed that the prominent functional groups existed in the formulations which could be an indication of good entrapment of metformin in a lipid matrix, and FT-IR results also ruled out any chemical interaction between the drug and the excipients.
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Curcumin-loaded Nanostructured Lipid Carriers for ocular drug delivery: Design optimization and characterization
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References
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Journal ArticleDOI
Solid lipid nanoparticles: Production, characterization and applications
W. Mehnert,Karsten Mäder +1 more
TL;DR: An overview about the selection of the ingredients, different ways of SLN production and SLN applications, and the in vivo fate of the carrier are presented.
Journal Article
Kinetic modeling on drug release from controlled drug delivery systems.
TL;DR: The mathematical modeling can ultimately help to optimize the design of a therapeutic device to yield information on the efficacy of various release models.
Journal ArticleDOI
Challenges and obstacles of ocular pharmacokinetics and drug delivery
TL;DR: This review presents an overview of the essential factors in ocular pharmacokinetics and selected pharmacological future challenges in ophthalmology.
Journal ArticleDOI
Ophthalmic drug delivery systems—Recent advances
TL;DR: In this paper, the authors focus on three representative areas of ophthalmic drug delivery systems: polymeric gels, colloidal systems, cyclodextrins and collagen shields.
Journal ArticleDOI
Anatomy and physiology of the cornea
Derek W. DelMonte,Terry Kim +1 more
TL;DR: The cornea lacks the neurobiological sophistication of the retina and the dynamic movement of the lens; yet, without its clarity, the eye would not be able to perform its necessary functions.
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