Journal ArticleDOI
Lipid peroxidation products as oxidative stress biomarkers.
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TLDR
The physiological levels of these lipid peroxidation products and potential application as biomarkers for oxidative stress status in vivo will be reviewed.Abstract:
Oxidative stress induced by reactive oxygen and nitrogen species has been implicated in the pathogenesis of various disorders and diseases Biomarkers are needed for assessment of oxidative stress status in vivo and also for health examination, diagnosis at early stage, prognosis, safe and efficient drug development, and evaluation of efficacy of drugs, foods, beverages, and supplements Lipids are susceptible to oxidation and lipid peroxidation products are potential biomarkers for oxidative stress status in vivo and its related diseases Recently, isoprostane, isoprostaglandin homologues from arachidonic acid, neuroprostanes from docosahexaenoic acid, hydroxyoctadecadienoic acid from linoleic acid, and oxysterols from cholesterol have received much attention as potential biomarkers for oxidative stress status in vivo The physiological levels of these lipid peroxidation products and potential application as biomarkers will be reviewedread more
Citations
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Assessment of antioxidant capacity in vitro and in vivo.
TL;DR: The available methods are critically reviewed on the basis of the mechanisms and dynamics of antioxidant action, and the methods are proposed to assess the capacity of radical scavenging and inhibition of lipid peroxidation both in vitro and in vivo.
Journal ArticleDOI
Biomarkers of lipid peroxidation in clinical material.
TL;DR: Characteristics of various lipid peroxidation products as biomarkers are reviewed on the basis of mechanisms and dynamics of their formation and metabolism and also on the methods of measurement, with an emphasis on the advantages and limitations.
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Redox regulation of antioxidants, autophagy, and the response to stress: Implications for electrophile therapeutics
Anna-Liisa Levonen,Bradford G. Hill,Emilia Kansanen,Jianhua Zhang,Victor M. Darley-Usmar,Victor M. Darley-Usmar +5 more
TL;DR: Current understanding of thiolelectrophile interactions and redox signaling suggests replacement of the oxidative stress hypothesis with a new redox biology paradigm, which provides an exciting and influential framework for guiding translational research.
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Bioavailability and Antioxidant Activity of Black Chokeberry (Aronia melanocarpa) Polyphenols: in vitro and in vivo Evidences and Possible Mechanisms of Action: A Review
TL;DR: It is evident that in vivo antioxidant action of chokeberry extends far beyond radical scavenging and includes suppression of reactive oxygen and nitrogen species formation, inhibition of prooxidant enzymes, restoration of antioxidant enzymes, and probably cellular signaling to regulate the level of antioxidant compounds and enzymes.
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Quercetin modulates OTA-induced oxidative stress and redox signalling in HepG2 cells - up regulation of Nrf2 expression and down regulation of NF-κB and COX-2.
TL;DR: The results of the study demonstrate for the first time that quercetin prevents OTA-induced toxicity in HepG2 cells and modulated Ota-induced oxidative stress and redox-signaling in Hepg2 cells.
References
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Journal ArticleDOI
A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism.
TL;DR: It is found that a series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase mechanism involving free radical-catalyzed peroxidation of arachidonic acid, and that these prostanoids may participate as pathophysiological mediators in oxidant injury.
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Lipid peroxidation and antioxidants as biomarkers of tissue damage.
TL;DR: The body has a hierarchy of defense strategies to deal with oxidative stress within different cellular compartments, and superimposed on these are gene-regulated defenses involving the heat-shock and oxidant stress proteins.
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Biomarkers of Oxidative Damage in Human Disease
TL;DR: Some of the more commonly used biomarkers of oxidative/nitrosative damage are discussed and selected examples of human studies are included.
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The oxidative environment and protein damage
TL;DR: The major fate of oxidised proteins is catabolism by proteosomal and lysosomal pathways, but some materials appear to be poorly degraded and accumulate within cells, and the accumulation of such damaged material may contribute to a range of human pathologies.
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Oxysterols and atherosclerosis
Andrew J. Brown,Wendy Jessup +1 more
TL;DR: There are a number of significant and quite widespread problems with current literature which preclude more than a tentative suggestion that oxysterol have a causal role in atherogenesis, and further studies are necessary to definitively determine the role of oxysterols in atherosclerosis.