Journal ArticleDOI
Liposomes co-loaded with metformin and chlorin e6 modulate tumor hypoxia during enhanced photodynamic therapy
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TLDR
Systemic administration of Met-HCe6-Liposomes followed by in vivo PDT achieved significantly improved therapeutic effects compared to that of PDT without metformin, representing a new strategy for the improvement of PDT efficacy through the modulation of tumor oxygenation by clinically approved agents.Abstract:
Though photodynamic therapy (PDT) has been widely used in the non-invasive destruction of solid tumors, the therapeutic efficacy of PDT is often limited by the hypoxic tumor environment. Herein, we report the innovative use of metformin, an oral hypoglycemic agent commonly used in the treatment of type II diabetes, to improve tumor oxygenation, and overcome tumor hypoxia-associated resistance to PDT. In our design, hydrophilic metformin and modified hydrophobic chlorin e6 (HCe6) are co-encapsulated within the inner cavity and outer membrane of liposomes, respectively. Due to the high uptake of liposome nanoparticles by tumors, and the sustained release of metformin, the intravenous administration of metformin (Met)-HCe6-Liposome nanoparticles greatly improves tumor oxygenation in several different tumor models, as revealed by in vivo photoacoustic imaging and ex vivo immunofluorescence staining. Systemic administration of Met-HCe6-Liposomes followed by in vivo PDT achieved significantly improved therapeutic effects compared to that of PDT without metformin. Hence, our study represents a new strategy for the improvement of PDT efficacy through the modulation of tumor oxygenation by clinically approved agents.read more
Citations
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Journal ArticleDOI
Theranostic Liposomes with Hypoxia-Activated Prodrug to Effectively Destruct Hypoxic Tumors Post-Photodynamic Therapy.
Liangzhu Feng,Liang Cheng,Liang Cheng,Ziliang Dong,Danlei Tao,Todd E. Barnhart,Weibo Cai,Meiwan Chen,Zhuang Liu +8 more
TL;DR: This work highlights a liposome-based theranostic nanomedicine that could utilize tumor hypoxia, a side effect of PDT, to trigger chemotherapy, resulting in greatly improved efficacy compared to conventional cancer PDT.
Journal ArticleDOI
Untangling Respective Effects of Heteroatom-doped Carbon Materials in Batteries, Supercapacitors and ORR to Design High-Performance Materials
TL;DR: In this article, a review comprehensively analyzes the relevant features of heteroatom-doped carbon composites used in batteries, supercapacitors, and the oxygen reduction reaction (ORR), and provides guidance for the design of more efficient materials.
Journal ArticleDOI
Advancing porphyrin's biomedical utility via supramolecular chemistry
TL;DR: Porphyrins are organic heterocyclic macrocycles with photophysical properties well-suited for clinical phototherapy and cancer imaging as discussed by the authors, however, their wider application in the clinical management of disease is barred by poor aqueous solubility, bioavailability, tumour accumulation and skin phototoxicity.
Journal ArticleDOI
Nanomedicine for tumor microenvironment modulation and cancer treatment enhancement
TL;DR: In this review, the latest efforts utilizing nanomedicine to modulate various features within the microenvironment of solid tumors, including tumor hypoxia, tumor pH, the extracellular matrix, as well as the immune microenvironment within the tumor are summarized.
Journal ArticleDOI
A Novel Theranostic Nanoplatform Based on Pd@Pt-PEG-Ce6 for Enhanced Photodynamic Therapy by Modulating Tumor Hypoxia Microenvironment
TL;DR: By integrating the merits of high tumor‐specific accumulation, hypoxia modulation function, and mild photothermal effect into a single nanoagent, Pd@Pt‐PEG‐Ce6 readily acts as an ideal nanotherapeutic platform for enhanced cancer PDT.
References
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Biomedical photoacoustic imaging
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