Journal ArticleDOI
Lithium and pregnancy. A cohort study on manic-depressive women.
B. Källen,A. Tandberg +1 more
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TLDR
Until better risk estimates are obtained, lithium should not be used in early pregnancy, and there is no statistically significant difference between delivery outcome in women on lithium and in Women on other psychotropic drugs.Abstract:
By record linkage of a discharge diagnosis registry and a medical birth registry we identified 350 women with manic-depressive disease who had born a child. The total delivery outcome was poorer than expected with a high perinatal death rate and a high malformation rate. Further studies revealed a high rate of perinatal deaths and/or congenital malformations among infants born of women who had used drugs in early pregnancy, and this phenomenon was concentrated to women who had used lithium and to heart defects. The sample is small, however, and there is no statistically significant difference between delivery outcome in women on lithium and in women on other psychotropic drugs. Until better risk estimates are obtained, lithium should not be used in early pregnancy.read more
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Evidence-based guidelines for treating bipolar disorder: Revised third edition recommendations from the British Association for Psychopharmacology
Guy M. Goodwin,Peter M. Haddad,I. N. Ferrier,Jeffrey K Aronson,T R H Barnes,Andrea Cipriani,David Coghill,Seena Fazel,John R. Geddes,Heinz Grunze,Emily A. Holmes,Oliver D. Howes,S. Hudson,N. Hunt,Ian Jones,Iain Macmillan,H. McAllister-Williams,D. R. Miklowitz,Richard Morriss,Marcus R. Munafò,Carol Paton,B. J. Saharkian,Kate E. A. Saunders,Julia Sinclair,David Taylor,Eduard Vieta,Allan H. Young +26 more
TL;DR: The British Association for Psychopharmacology guidelines specify the scope and targets of treatment for bipolar disorder, and recommend strategies for the use of medicines in short-term treatment of episodes, relapse prevention and stopping treatment.
Journal ArticleDOI
Pharmacologic management of psychiatric illness during pregnancy: Dilemmas and guidelines
TL;DR: Exposure to certain psychotropic drugs in utero may increase the risk for some specific congenital anomalies, but the rate of occurrence of these anomalies even with the increased risk remains low.
Journal ArticleDOI
A Reevaluation of Risk of In Utero Exposure to Lithium
TL;DR: More recent epidemiologic data indicate that the teratogenic risk of first-trimester lithium exposure is lower than previously suggested, and the clinical management of women with bipolar disorder who have childbearing potential should be modified with this revised risk estimate.
Journal ArticleDOI
Toxicity of lithium to humans and the environment—A literature review
Hal Aral,Angelica Vecchio-Sadus +1 more
TL;DR: This review has indicated that lithium is not expected to bioaccumulate and its human and environmental toxicity are low and large doses of lithium are given to patients with bipolar disorder.
Journal ArticleDOI
Physiologic and pharmacokinetic changes in pregnancy.
TL;DR: Understating the changes in maternal physiology during pregnancy and their profound impact on the pharmacokinetic properties of drugs in pregnancy is essential to optimize maternal and fetal health.
References
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Journal ArticleDOI
Lithium, ebstein's anomaly, and other congenital heart defects
Nora Jj,A.H. Nora,W.H. Toews +2 more
Journal ArticleDOI
Cigarette smoking as an etiologic factor in cleft lip and palate.
TL;DR: It is suggested that maternal smoking is one of many factors of importance in the etiology of cleft lip and cleft palate in humans.
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Cardiovascular Malformations with Lithium Use During Pregnancy
TL;DR: Findings justify a conservative policy on the use of lithium with fertile and pregnant women and infants exposed to lithium appear to have a higher than expected ratio of cardiovascular anomalies to all anomalies and may have an increased risk of congenital heart disease.
Journal ArticleDOI
Lithium and pregnancy. I. Report from the Register of Lithium Babies.
TL;DR: The data show that the risk of teratogenic effects is lower than one might have expected from some of the studies carried out on rats and mice, but they do not answer the question of whether or not lithium isTeratogenic in man.
Journal ArticleDOI
Possible teratogenicity of imipramine/chloropyramine
TL;DR: Use of an imipramine/chloropyramine combination in the first trimester was associated with two craniofacial malformations and one centralnervous-system anomaly, and in one case of malformation, amitriptyline had be taken in early pregnancy and in another case it had been taken during the third trimester.