Liver ischemia and reperfusion injury: new insights into mechanisms of innate-adaptive immune-mediated tissue inflammation.
TLDR
This review focuses on recent progress in the mechanism of liver innate immune activation by IR, and the interlocked molecular signaling pathways in the context of multiple liver cell types, the IRI kinetics and positive versus negative regulatory loops in the innate immuneactivation process are discussed.About:
This article is published in American Journal of Transplantation.The article was published on 2011-08-01 and is currently open access. It has received 342 citations till now. The article focuses on the topics: Liver cell & Innate immune system.read more
Citations
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Liver macrophages in tissue homeostasis and disease
Oliver Krenkel,Frank Tacke +1 more
TL;DR: Novel findings regarding the origin, classification and function of hepatic macrophages are highlighted, and their divergent roles in the healthy and diseased liver are discussed.
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Targeting hepatic macrophages to treat liver diseases
TL;DR: Evidence from mouse models and early clinical studies in patients with non-alcoholic steatohepatitis and fibrosis support the notion that pathogenic macrophage subsets can be successfully translated into novel treatment options for patients with liver disease.
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Ischaemia-reperfusion injury in liver transplantation--from bench to bedside.
TL;DR: The latest mechanistic insights into innate–adaptive immune crosstalk and cell activation cascades that lead to inflammation-mediated injury in livers stressed by ischaemia–reperfusion are highlighted, progress in large animal experiments is discussed and efforts to minimize liver IRI in patients who have received a liver transplant are examined.
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Sterile Inflammation in the Liver
Paul Kubes,Wajahat Z. Mehal +1 more
TL;DR: Identification of endogenous damage-associated molecular patterns, their receptors, signaling pathways, and cytokines now provides a wide range of therapeutic targets for which many antagonists are already available.
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Hepatic macrophages in homeostasis and liver diseases: from pathogenesis to novel therapeutic strategies.
Changqing Ju,Frank Tacke +1 more
TL;DR: The current knowledge on the origins and composition of hepatic macrophages, their functions in maintaining hepatic homeostasis, and their involvement in both promoting and resolving liver inflammation, injury, and fibrosis are summarized.
References
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The regulation of IL-10 production by immune cells
Margarida Saraiva,Anne O'Garra +1 more
TL;DR: Understanding the specific molecular events that regulate the production of IL-10 will help to answer the remaining questions that are important for the design of new strategies of immune intervention.
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Interleukin-22, a T H 17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
Yan Zheng,Dimitry M. Danilenko,Patricia Valdez,Ian Kasman,Jeffrey Eastham-Anderson,Jianfeng Wu,Wenjun Ouyang +6 more
TL;DR: The results suggest that TH17 cells, through the production of both IL-22 and IL-17, might have essential functions in host defence and in the pathogenesis of autoimmune diseases such as psoriasis.
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Intravascular danger signals guide neutrophils to sites of sterile inflammation.
Braedon McDonald,Keir Pittman,Gustavo B. Menezes,Simon A. Hirota,Ingrid Slaba,Christopher C. M. Waterhouse,Paul L. Beck,Daniel A. Muruve,Paul Kubes +8 more
TL;DR: Dynamic in vivo imaging revealed a multistep hierarchy of directional cues that guide neutrophil localization to sites of sterile inflammation, and the underlying mechanisms of recruitment of neutrophils into injured tissue.
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The Liver as a Lymphoid Organ
TL;DR: The liver receives blood from both the systemic circulation and the intestine, and in distinctive, thin-walled sinusoids this mixture passes over a large macrophage population, termed Kupffer cells, which has resulted in a distinctive local immune environment.
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Liver : An Organ with Predominant Innate Immunity
TL;DR: The liver is an organ with predominant innate immunity, playing an important role not only in host defenses against invading microorganisms and tumor transformation but also in liver injury and repair.